China Original Largest Manufacturer sales Guanosine CAS 118-00-3 CAS NO.118-00-3

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Guanosine Basic information Description Reference Product Name: Guanosine Synonyms: usafcb-11;O-(BETA-D-RIBOFURANOSYL)GUANINE;D-GUANOSINE;GR;GUANOSINE;GUANINE-9-BETA-D-RIBOFURANOSIDE;GUANINE RIBOSIDE;9-[BETA-D-RIBOFURANOSYL]GUANINE CAS: 118-00-3 MF: C10H13N5O5 MW: 283.24 EINECS: 204-227-8 Product Categories: Inhibitors;nucleoside;Nucleic acids;Bases & Related Reagents;Nucleotides;Carbohydrates & Derivatives;Pharmaceutical Intermediates;Purine;API intermediates;Nucleotides and Nucleosides;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents Mol File: 118-00-3.mol   Guanosine Chemical Properties Melting point  250 °C (dec.) (lit.) alpha  -62 º (c=3, in 0.1 N NaOH) Boiling point  425.8°C (rough estimate) density  1.3790 (rough estimate) refractive index  -76 ° (C=1, 1mol/L NaOH) storage temp.  room temp solubility  0.1 M NaOH: 0.1 g/mL, clear, slightly yellow pka pK1:1.9(＋1);pK2:9.25(0);pK3:12.33(OH) (25°C) form  Powder color  White to light yellow Odor Odorless optical activity [α]20/D -73±2°, c = 1.5% in 1 M NaOH Water Solubility  0.75 g/L (25 ºC) Merck  14,4566 BRN  625911 InChIKey NYHBQMYGNKIUIF-UUOKFMHZSA-N CAS DataBase Reference 118-00-3(CAS DataBase Reference) NIST Chemistry Reference guanosine(118-00-3) EPA Substance Registry System Guanosine (118-00-3)   Safety Information Hazard Codes  T,Xi Risk Statements  25 Safety Statements  45-24/25-23 RIDADR  UN 2811 6.1/PG 3 WGK Germany  3 RTECS  MF8750000 F  10-23 Hazard Note  Irritant TSCA  Yes HazardClass  6.1 PackingGroup  Ⅲ HS Code  29349990 MSDS Information Provider Language 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate English SigmaAldrich English ACROS English ALFA English   Guanosine Usage And Synthesis Description Guanosine is a purine nucleoside, in which the guanine attached to the C1 carbon of a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Its phosphorylated derivatives include GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). These guanosine derivatives are very important in various biochemical processes, such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction. Guanosine is thought to have neuroprotective properties. It can reduce neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. It is shown to be protective in central nervous system diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. Guanosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency, which is an inborn error of metabolism. Reference L. E. B. Bettio, J. Gil-Mohapel, A. L. S. Rodrigues, Guanosine and its role in neurophathologies, Purinergic Signal, 2016, vol. 12, pp. 411-426 Description Guanosine is a purine nucleoside that is comprised of the purine base guanine attached to a ribose moiety. Mono-, di-, tri-, and cyclic monophosphorylated forms of guanosine (GMP, GDP, GTP, and cGMP, respectively) are essential for a variety of endogenous biochemical processes, such as signal transduction, metabolism, and RNA synthesis. Chemical Properties White, crystalline powder; odorless; mild saline taste. Very slightly soluble in cold water; soluble in boiling water, dilute mineral acids, hot acetic acid, and dilute bases; insoluble in alcohol, ether, chloroform, and benzene. Uses A constituent of nucleic acids. Uses Guanosine has been used: as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS) as a component of Mouse Embryonic Fibroblasts (MEFs) culture as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC Uses Guanosine is used as a constituent of nucleic acids. It is used in metallic paints, simulated pearls,plastics,cosmetics industry etc,. It has been also used in pharmacokinetics as a prodrug. Guanosine is used in cell culture applications as a precursor of GMP. Definition A NUCLEOSIDE present in DNA and RNA and consisting of guanine linked to D-ribose via a β-glycosidic bond. Definition ChEBI: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N9-glycosidic bond. General Description Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels. Biochem/physiol Actions Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury. Purification Methods It crystallises from water as a dihydrate. Dry it at 110o.[Beilstein 26/18 V 81.]   Guanosine Preparation Products And Raw materials Preparation Products Acyclovir-->Ribavirin-->Guanosine 5'-monophosphate disodium salt-->Calcium 5'-ribonucleotide-->5'-Guanylic acid-->7-METHYLGUANINE-->N,9-Diacetylguanine-->guanosine 3'-(dihydrogen phosphate)-->2',3'-cyclic UMP-->5-Bromouridine-->7,8-Dihydro-7-methylguanosine-->5-Methyluridine-->cytidine 2',3'-(hydrogen phosphate)-->7-METHYLGUANOSINE-->8-HYDROXYGUANOSINE-->6-THIOGUANOSINE Tag:Guanosine(118-00-3) Related Product Information

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Guanosine Basic information Description Reference Product Name: Guanosine Synonyms: usafcb-11;O-(BETA-D-RIBOFURANOSYL)GUANINE;D-GUANOSINE;GR;GUANOSINE;GUANINE-9-BETA-D-RIBOFURANOSIDE;GUANINE RIBOSIDE;9-[BETA-D-RIBOFURANOSYL]GUANINE CAS: 118-00-3 MF: C10H13N5O5 MW: 283.24 EINECS: 204-227-8 Product Categories: Inhibitors;nucleoside;Nucleic acids;Bases & Related Reagents;Nucleotides;Carbohydrates & Derivatives;Pharmaceutical Intermediates;Purine;API intermediates;Nucleotides and Nucleosides;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents Mol File: 118-00-3.mol   Guanosine Chemical Properties Melting point  250 °C (dec.) (lit.) alpha  -62 º (c=3, in 0.1 N NaOH) Boiling point  425.8°C (rough estimate) density  1.3790 (rough estimate) refractive index  -76 ° (C=1, 1mol/L NaOH) storage temp.  room temp solubility  0.1 M NaOH: 0.1 g/mL, clear, slightly yellow pka pK1:1.9(＋1);pK2:9.25(0);pK3:12.33(OH) (25°C) form  Powder color  White to light yellow Odor Odorless optical activity [α]20/D -73±2°, c = 1.5% in 1 M NaOH Water Solubility  0.75 g/L (25 ºC) Merck  14,4566 BRN  625911 InChIKey NYHBQMYGNKIUIF-UUOKFMHZSA-N CAS DataBase Reference 118-00-3(CAS DataBase Reference) NIST Chemistry Reference guanosine(118-00-3) EPA Substance Registry System Guanosine (118-00-3)   Safety Information Hazard Codes  T,Xi Risk Statements  25 Safety Statements  45-24/25-23 RIDADR  UN 2811 6.1/PG 3 WGK Germany  3 RTECS  MF8750000 F  10-23 Hazard Note  Irritant TSCA  Yes HazardClass  6.1 PackingGroup  Ⅲ HS Code  29349990 MSDS Information Provider Language 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate English SigmaAldrich English ACROS English ALFA English   Guanosine Usage And Synthesis Description Guanosine is a purine nucleoside, in which the guanine attached to the C1 carbon of a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Its phosphorylated derivatives include GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate), and GTP (guanosine triphosphate). These guanosine derivatives are very important in various biochemical processes, such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction. Guanosine is thought to have neuroprotective properties. It can reduce neuroinflammation, oxidative stress, and excitotoxicity, as well as exerting trophic effects in neuronal and glial cells. It is shown to be protective in central nervous system diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, nociception, and depression. Guanosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency, which is an inborn error of metabolism. Reference L. E. B. Bettio, J. Gil-Mohapel, A. L. S. Rodrigues, Guanosine and its role in neurophathologies, Purinergic Signal, 2016, vol. 12, pp. 411-426 Description Guanosine is a purine nucleoside that is comprised of the purine base guanine attached to a ribose moiety. Mono-, di-, tri-, and cyclic monophosphorylated forms of guanosine (GMP, GDP, GTP, and cGMP, respectively) are essential for a variety of endogenous biochemical processes, such as signal transduction, metabolism, and RNA synthesis. Chemical Properties White, crystalline powder; odorless; mild saline taste. Very slightly soluble in cold water; soluble in boiling water, dilute mineral acids, hot acetic acid, and dilute bases; insoluble in alcohol, ether, chloroform, and benzene. Uses A constituent of nucleic acids. Uses Guanosine has been used: as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS) as a component of Mouse Embryonic Fibroblasts (MEFs) culture as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC Uses Guanosine is used as a constituent of nucleic acids. It is used in metallic paints, simulated pearls,plastics,cosmetics industry etc,. It has been also used in pharmacokinetics as a prodrug. Guanosine is used in cell culture applications as a precursor of GMP. Definition A NUCLEOSIDE present in DNA and RNA and consisting of guanine linked to D-ribose via a β-glycosidic bond. Definition ChEBI: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N9-glycosidic bond. General Description Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels. Biochem/physiol Actions Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury. Purification Methods It crystallises from water as a dihydrate. Dry it at 110o.[Beilstein 26/18 V 81.]   Guanosine Preparation Products And Raw materials Preparation Products Acyclovir-->Ribavirin-->Guanosine 5'-monophosphate disodium salt-->Calcium 5'-ribonucleotide-->5'-Guanylic acid-->7-METHYLGUANINE-->N,9-Diacetylguanine-->guanosine 3'-(dihydrogen phosphate)-->2',3'-cyclic UMP-->5-Bromouridine-->7,8-Dihydro-7-methylguanosine-->5-Methyluridine-->cytidine 2',3'-(hydrogen phosphate)-->7-METHYLGUANOSINE-->8-HYDROXYGUANOSINE-->6-THIOGUANOSINE Tag:Guanosine(118-00-3) Related Product Information