China Largest Manufacturer factory sales N-(Hydroxymethyl)phthalimide CAS118-29-6 CAS NO.118-29-6

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N-(Hydroxymethyl)phthalimide Basic information Product Name: N-(Hydroxymethyl)phthalimide Synonyms: 2-methylolisoindoline-1,3-quinone;N-(HydroxymethyL;PHTHALIMIDOMETHANOL;N-(HYDROXYMETHYL)PHTHALIMIDE;HYDROXYMETHYL PHTHALIMIDE;IFLAB-BB F0777-0575;AURORA KA-454;2-(hydroxymethyl)-1h-isoindole-3(2h)-dione CAS: 118-29-6 MF: C9H7NO3 MW: 177.16 EINECS: 204-241-4 Product Categories: N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;pharmacetical;intermediates;fine chemicals Mol File: 118-29-6.mol   N-(Hydroxymethyl)phthalimide Chemical Properties Melting point  147-149 °C (lit.) Boiling point  309.06°C (rough estimate) density  1.3312 (rough estimate) refractive index  1.5200 (estimate) storage temp.  Store below +30°C. pka 13.17±0.10(Predicted) form  Fine Crystalline Powder color  White BRN  140946 InChIKey MNSGOOCAMMSKGI-UHFFFAOYSA-N CAS DataBase Reference 118-29-6(CAS DataBase Reference) NIST Chemistry Reference 1H-isoindole-1,3(2h)-dione, 2-(hydroxymethyl)-(118-29-6) EPA Substance Registry System N-(Hydroxymethyl)phthalimide (118-29-6)   Safety Information Safety Statements  22-24/25 WGK Germany  3 RTECS  TI5270000 TSCA  Yes HS Code  29251995 MSDS Information Provider Language N-(Hydroxymethyl)phthalimide English ACROS English SigmaAldrich English ALFA English   N-(Hydroxymethyl)phthalimide Usage And Synthesis Chemical Properties white crystalline powder Uses N-(Hydroxymethyl)phthalimide is used as a reactant in the synthesis of 5-[(3-aralkyl amido/imidoalkyl)phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as antiviral agents. Uses For amidomethylation of aromatics in triflic acid. Definition ChEBI: A primary alcohol comprising phthalimide carrying an N-hydroxymethyl substituent. Preparation To a flask equipped with a mechanical stirrer and condenser is added 511 gm (3.47 moles) of phthalimide, 260 ml of 40% formalin (3.47 moles), and 1750 ml of water. The mixture is refluxed for about 5-10 min or until a clear solution results (if any insoluble material remains, it is first filtered). Then the mixture is cooled for several hours. The resulting product is filtered with suction, washed with cold water, and air-dried to afford 594 gm (96%), m.p. 137-141°C. NOTE: The product should not be oven-dried since it decomposes with the loss of formaldehyde. Recrystallization of the product from ethanol affords 94% recovery of the original material with the same melting point range. Synthesis Reference(s) Journal of the American Chemical Society, 77, p. 1913, 1955 DOI: 10.1021/ja01612a068   N-(Hydroxymethyl)phthalimide Preparation Products And Raw materials Raw materials Ammonium hydroxide-->Formaldehyde-->Phthalic anhydride-->Phthalimide Preparation Products PHTHALAMIDE-->N-(Bromomethyl)phthalimide-->A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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N-(Hydroxymethyl)phthalimide Basic information Product Name: N-(Hydroxymethyl)phthalimide Synonyms: 2-methylolisoindoline-1,3-quinone;N-(HydroxymethyL;PHTHALIMIDOMETHANOL;N-(HYDROXYMETHYL)PHTHALIMIDE;HYDROXYMETHYL PHTHALIMIDE;IFLAB-BB F0777-0575;AURORA KA-454;2-(hydroxymethyl)-1h-isoindole-3(2h)-dione CAS: 118-29-6 MF: C9H7NO3 MW: 177.16 EINECS: 204-241-4 Product Categories: N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;pharmacetical;intermediates;fine chemicals Mol File: 118-29-6.mol   N-(Hydroxymethyl)phthalimide Chemical Properties Melting point  147-149 °C (lit.) Boiling point  309.06°C (rough estimate) density  1.3312 (rough estimate) refractive index  1.5200 (estimate) storage temp.  Store below +30°C. pka 13.17±0.10(Predicted) form  Fine Crystalline Powder color  White BRN  140946 InChIKey MNSGOOCAMMSKGI-UHFFFAOYSA-N CAS DataBase Reference 118-29-6(CAS DataBase Reference) NIST Chemistry Reference 1H-isoindole-1,3(2h)-dione, 2-(hydroxymethyl)-(118-29-6) EPA Substance Registry System N-(Hydroxymethyl)phthalimide (118-29-6)   Safety Information Safety Statements  22-24/25 WGK Germany  3 RTECS  TI5270000 TSCA  Yes HS Code  29251995 MSDS Information Provider Language N-(Hydroxymethyl)phthalimide English ACROS English SigmaAldrich English ALFA English   N-(Hydroxymethyl)phthalimide Usage And Synthesis Chemical Properties white crystalline powder Uses N-(Hydroxymethyl)phthalimide is used as a reactant in the synthesis of 5-[(3-aralkyl amido/imidoalkyl)phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as antiviral agents. Uses For amidomethylation of aromatics in triflic acid. Definition ChEBI: A primary alcohol comprising phthalimide carrying an N-hydroxymethyl substituent. Preparation To a flask equipped with a mechanical stirrer and condenser is added 511 gm (3.47 moles) of phthalimide, 260 ml of 40% formalin (3.47 moles), and 1750 ml of water. The mixture is refluxed for about 5-10 min or until a clear solution results (if any insoluble material remains, it is first filtered). Then the mixture is cooled for several hours. The resulting product is filtered with suction, washed with cold water, and air-dried to afford 594 gm (96%), m.p. 137-141°C. NOTE: The product should not be oven-dried since it decomposes with the loss of formaldehyde. Recrystallization of the product from ethanol affords 94% recovery of the original material with the same melting point range. Synthesis Reference(s) Journal of the American Chemical Society, 77, p. 1913, 1955 DOI: 10.1021/ja01612a068   N-(Hydroxymethyl)phthalimide Preparation Products And Raw materials Raw materials Ammonium hydroxide-->Formaldehyde-->Phthalic anhydride-->Phthalimide Preparation Products PHTHALAMIDE-->N-(Bromomethyl)phthalimide-->A-(HYDROXYMETHYL)BENZENACETIC ACID METHYL ESTER