China Largest Manufacturer factory sales Vanillic Acid CAS 121-34-6 CAS NO.121-34-6

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Vanillic acid Basic information Description References Product Name: Vanillic acid Synonyms: PROTOCATECHUIC ACID 3-METHYL ETHER;TIMTEC-BB SBB008280;RARECHEM AL BO 0061;VANILLIC ACID;VENILLIC ACID;4-HYDROXY-3-METHOXYBENZOIC ACID;AKOS BBS-00003785;FEMA 3988 CAS: 121-34-6 MF: C8H8O4 MW: 168.15 EINECS: 204-466-8 Product Categories: Phenols;Armoracia rusticana (Horseradish);Hordeum vulgare (Barley);Hypericum perforatum (St John′;s wort);Allium cepa (Onion);Allium sativum (Garlic);Aspalathus linearis (Rooibos tea);C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Cichorium intybus (Chicory);Curcuma longa (Turmeric);Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;BUILDING BLOCKS;BenzoicAcidDerivative;Organic acids;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Elettaria Cardamomum (Cardamom);Ginkgo biloba;Nutrition Research;Organic Building Blocks;Panax ginseng;Phytochemicals by Plant (Food/Spice/Herb);Vaccinium myrtillus (Bilberry);Zingiber officinale (Ginger);Building block;FINE Chemical & INTERMEDIATES;VX:15689727968 Mol File: 121-34-6.mol   Vanillic acid Chemical Properties Melting point  208-210 °C(lit.) Boiling point  257.07°C (rough estimate) density  1.3037 (rough estimate) FEMA  3988 | 4-HYDROXY-3-METHOXYBENZOIC ACID refractive index  1.5090 (estimate) storage temp.  Store below +30°C. solubility  Acetonitrile (Slightly), Aqueous Base (Slightly), DMSO (Slightly), Methanol (Sli pka pKa 4.53(H2O t = 25 c = 0.016–0.001) (Uncertain) form  Liquid color  Clear colorless to brown, may darken during storage Water Solubility  Soluble in water, alcohol and ether. Merck  14,9931 JECFA Number 959 BRN  2208364 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. InChIKey WKOLLVMJNQIZCI-UHFFFAOYSA-N CAS DataBase Reference 121-34-6(CAS DataBase Reference) NIST Chemistry Reference Benzoic acid, 4-hydroxy-3-methoxy-(121-34-6) EPA Substance Registry System Vanillic acid (121-34-6)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  37/39-26-36 WGK Germany  1 RTECS  YW5300000 Hazard Note  Irritant TSCA  Yes HS Code  29189090 MSDS Information Provider Language 4-Hydroxy-3-methoxybenzoic acid English SigmaAldrich English ACROS English ALFA English   Vanillic acid Usage And Synthesis Description Vanillic acid is a dihydroxybenzoic acid that can be used as a flavoring agent. As an oxidized form of vanillin, it is the intermediate product during the two-step bioconversion process from ferulic acid to vanillin. It exists in high amount in the root of Angelica sinenisis, which is a plant used in traditional Chinese medicine. It also exists in acal oil, argan oil as well as wine and vinegar. It can be used in the synthesis of the analeptic drug etamivan, modecainide, brovanexine, vanitiolide, and vanyldisulfamide. It can be manufactured through the oxidation of vanillin to the carboxylic acid. References # # Chemical Properties white odourless crystals or powder Chemical Properties 4-Hydroxy-3-methoxybenzoic acid has a vanilla-like odor and taste. Occurrence Reported found in guava, grape, brandy, rum, whiskey, sherry, red and white wines, Scotch and Canadian whiskey, pork (fried), cocoa, peanuts (raw), mushrooms, guava fruit, mangos (fresh), wort, vanilla and black chokeberries. Uses Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, an d antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent. Uses A flavoring agent. Uses Vanillic acid is used as a flavoring agent in food. It acts as an intermediate in the production of vanillin from ferulic acid. Further, it is used in wine and vinegar. Preparation Prepared by bioconversion of ferulic acid by means of a vanillate-negative mutant of Pseudomonas fluorescens strain BS13. Also prepared by whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus Definition ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3. Aroma threshold values Aroma at 5.0%: weak vanilla, creamy, milky. Taste threshold values Taste characteristics at 100 ppm: weak sweet resinous vanilla, creamy with a smooth sweetness and body, slightly chocolate-like with a spicy vanitrop nuance Synthesis Reference(s) Journal of the American Chemical Society, 68, p. 429, 1946 DOI: 10.1021/ja01207a025 Organic Syntheses, Coll. Vol. 4, p. 972, 1963 General Description Vanillic acid is one of the key aromatic volatile compounds of vanilla beans. Biochem/physiol Actions Taste at 100 ppm   Vanillic acid Preparation Products And Raw materials Raw materials Thionyl chloride-->Phosphorus trichloride-->1-Pentanol-->Valeric acid-->butene-->3-Methoxysalicylic acid-->Ferulic Acid-->4-BENZYLOXY-3-METHOXYBENZALDEHYDE-->Protocatechuic acid-->Hydrogen peroxide-->ISOEUGENOL Preparation Products 1-(4-Hydroxy-3-Methoxyphenyl)-3-hydroxy-2-(2-Methoxyphenoxy) propane-1-one-->BUTYLFORMAMIDE-->4-Amino-3-methoxybenzoic acid-->Methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate-->AGMWEOLWLPKJFM-UHFFFAOYSA-N-->4-BENZYLOXY-5-METHOXY-2-NITRO-BENZOIC ACID

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Vanillic acid Basic information Description References Product Name: Vanillic acid Synonyms: PROTOCATECHUIC ACID 3-METHYL ETHER;TIMTEC-BB SBB008280;RARECHEM AL BO 0061;VANILLIC ACID;VENILLIC ACID;4-HYDROXY-3-METHOXYBENZOIC ACID;AKOS BBS-00003785;FEMA 3988 CAS: 121-34-6 MF: C8H8O4 MW: 168.15 EINECS: 204-466-8 Product Categories: Phenols;Armoracia rusticana (Horseradish);Hordeum vulgare (Barley);Hypericum perforatum (St John′;s wort);Allium cepa (Onion);Allium sativum (Garlic);Aspalathus linearis (Rooibos tea);C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Cichorium intybus (Chicory);Curcuma longa (Turmeric);Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;BUILDING BLOCKS;BenzoicAcidDerivative;Organic acids;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Elettaria Cardamomum (Cardamom);Ginkgo biloba;Nutrition Research;Organic Building Blocks;Panax ginseng;Phytochemicals by Plant (Food/Spice/Herb);Vaccinium myrtillus (Bilberry);Zingiber officinale (Ginger);Building block;FINE Chemical & INTERMEDIATES;VX:15689727968 Mol File: 121-34-6.mol   Vanillic acid Chemical Properties Melting point  208-210 °C(lit.) Boiling point  257.07°C (rough estimate) density  1.3037 (rough estimate) FEMA  3988 | 4-HYDROXY-3-METHOXYBENZOIC ACID refractive index  1.5090 (estimate) storage temp.  Store below +30°C. solubility  Acetonitrile (Slightly), Aqueous Base (Slightly), DMSO (Slightly), Methanol (Sli pka pKa 4.53(H2O t = 25 c = 0.016–0.001) (Uncertain) form  Liquid color  Clear colorless to brown, may darken during storage Water Solubility  Soluble in water, alcohol and ether. Merck  14,9931 JECFA Number 959 BRN  2208364 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. InChIKey WKOLLVMJNQIZCI-UHFFFAOYSA-N CAS DataBase Reference 121-34-6(CAS DataBase Reference) NIST Chemistry Reference Benzoic acid, 4-hydroxy-3-methoxy-(121-34-6) EPA Substance Registry System Vanillic acid (121-34-6)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  37/39-26-36 WGK Germany  1 RTECS  YW5300000 Hazard Note  Irritant TSCA  Yes HS Code  29189090 MSDS Information Provider Language 4-Hydroxy-3-methoxybenzoic acid English SigmaAldrich English ACROS English ALFA English   Vanillic acid Usage And Synthesis Description Vanillic acid is a dihydroxybenzoic acid that can be used as a flavoring agent. As an oxidized form of vanillin, it is the intermediate product during the two-step bioconversion process from ferulic acid to vanillin. It exists in high amount in the root of Angelica sinenisis, which is a plant used in traditional Chinese medicine. It also exists in acal oil, argan oil as well as wine and vinegar. It can be used in the synthesis of the analeptic drug etamivan, modecainide, brovanexine, vanitiolide, and vanyldisulfamide. It can be manufactured through the oxidation of vanillin to the carboxylic acid. References # # Chemical Properties white odourless crystals or powder Chemical Properties 4-Hydroxy-3-methoxybenzoic acid has a vanilla-like odor and taste. Occurrence Reported found in guava, grape, brandy, rum, whiskey, sherry, red and white wines, Scotch and Canadian whiskey, pork (fried), cocoa, peanuts (raw), mushrooms, guava fruit, mangos (fresh), wort, vanilla and black chokeberries. Uses Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, an d antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent. Uses A flavoring agent. Uses Vanillic acid is used as a flavoring agent in food. It acts as an intermediate in the production of vanillin from ferulic acid. Further, it is used in wine and vinegar. Preparation Prepared by bioconversion of ferulic acid by means of a vanillate-negative mutant of Pseudomonas fluorescens strain BS13. Also prepared by whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus Definition ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3. Aroma threshold values Aroma at 5.0%: weak vanilla, creamy, milky. Taste threshold values Taste characteristics at 100 ppm: weak sweet resinous vanilla, creamy with a smooth sweetness and body, slightly chocolate-like with a spicy vanitrop nuance Synthesis Reference(s) Journal of the American Chemical Society, 68, p. 429, 1946 DOI: 10.1021/ja01207a025 Organic Syntheses, Coll. Vol. 4, p. 972, 1963 General Description Vanillic acid is one of the key aromatic volatile compounds of vanilla beans. Biochem/physiol Actions Taste at 100 ppm   Vanillic acid Preparation Products And Raw materials Raw materials Thionyl chloride-->Phosphorus trichloride-->1-Pentanol-->Valeric acid-->butene-->3-Methoxysalicylic acid-->Ferulic Acid-->4-BENZYLOXY-3-METHOXYBENZALDEHYDE-->Protocatechuic acid-->Hydrogen peroxide-->ISOEUGENOL Preparation Products 1-(4-Hydroxy-3-Methoxyphenyl)-3-hydroxy-2-(2-Methoxyphenoxy) propane-1-one-->BUTYLFORMAMIDE-->4-Amino-3-methoxybenzoic acid-->Methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate-->AGMWEOLWLPKJFM-UHFFFAOYSA-N-->4-BENZYLOXY-5-METHOXY-2-NITRO-BENZOIC ACID Product Name: Succinimide Synonyms: 3,4-Dihydropyrrole-2,5-dione;SI;Succinic imide;SUCCINIMIDE;SUCCINIC ACID IMIDE;3,4-Dihydropyrrolidinone;2-Hydroxy-1-pyrroline-5-one;succiminide CAS: 123-56-8 MF: C4H5NO2 MW: 99.09 EINECS: 204-635-6 Product Categories: Miscellaneous Mol File: 123-56-8.mol   Succinimide Chemical Properties Melting point  123-125 °C (lit.) Boiling point  285-290 °C (lit.) density  1.41 vapor pressure  <1 hPa (50 °C) refractive index  1.4166 (estimate) Fp  201 °C storage temp.  Store below +30°C. solubility  330g/l pka 9.6(at 25℃) form  Powder or Flakes color  Off-white to beige to light brown PH 4-6 (200g/l, H2O) Water Solubility  Soluble in water and ethanol. Insoluble in ether and chloroform. Merck  14,8871 BRN  108440 InChIKey KZNICNPSHKQLFF-UHFFFAOYSA-N CAS DataBase Reference 123-56-8(CAS DataBase Reference) NIST Chemistry Reference 2,5-Pyrrolidinedione(123-56-8) EPA Substance Registry System Succinimide (123-56-8)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-36-26-S24/25 WGK Germany  2 RTECS  WN2200000 TSCA  Yes HS Code  29251995 Toxicity LD50 orally in rats: 14 g/kg (Melon) MSDS Information Provider Language 2,5-Diketopyrrolidine English SigmaAldrich English ACROS English ALFA English   Succinimide Usage And Synthesis Description Succinimide is a natural product found in Xanthium strumarium and Panax notoginseng with data available.Succinimide is a colorless acicular crystal or thin solid with light brown luster. It tastes sweet. Easily soluble in water, alcohol or sodium hydroxide solution, insoluble in ether, chloroform, etc. Succinimide dispersants appear as dark or brown-colored liquids with a thickness or viscosity similar to heavy syrup. They have little or no solubility in water, and because they are denser than water, will sink in a water environment. They are readily soluble in oil and lighter weight hydrocarbons, such as gasoline. Succinimide dispersants have very low vapor pressure and little noticeable odor at ambient temperatures. Chemical Properties white crystalline powder Uses Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson's agents. Succinimide is the key intermediate for deamidation of asparagine (Asn) and isom-erization of aspartic acid (Asp) residues in a protein or peptide, either in vivo or invitro (Wakankar and Borchardt 2006). Formation of succinimide is the rate-deter-mining step in these reactions. Uses Succinimide is used in organic syntheses and in industrial silver plating processes. It is a reagent that is used in the synthesis of Lumiflavin (L473900), which is a toxic photolysis product of vitamin B2 (R415000). Further, it is used to form covalent bonds between proteins, peptides and plastics. In addition to this, it is used as an important raw material for the synthesis of heterocyclic compounds through N-acyliminium cyclizations. Preparation To a flask equipped with a dropping funnel, mechanical stirrer, and a 40 cm long side arm of not less than 10 mm inside diameter is added 236 gm (2.0 mole) of succinic acid. The flask is cooled and 270 ml (4.0 moles) of 28% aqueous ammonia is slowly added with stirring. The flask is rapidly heated with an oil bath until 200 ml of water distils. The temperature of the bath is rapidly raised to 275°C. Succinimide starts to distil over the range 275-289°C, to afford 168 gm of crude product which solidifies on cooling. The intermediate fraction, boiling between 102° and 275°C, is redistilled to afford 10.0 gm of crude succinimide, b.p. 275-289°C. The combined product (178 gm) is added to 178 gm of hot ethanol. The solution is cooled, the crystals filtered, washed with 25 ml of cold ethanol, and dried to afford 163-164 gm (82-83%), m.p. 123-125°C. Approximately 4-5 gm of additional product may be obtained by concen­trating the mother liquor. Recent Japanese patents suggested inert aprotic solvents such as cyclic amides (e.g., N-methylpyrrolidone, N-acetyl-2-pyrrolidone, DMF, or tet-ramethylurea) and azeotroping solvents (e.g., toluene, 0-xylene, hexane, or pentane) or other high-boiling solvents (e.g., chlorobenzene or chlo-rotoluene) as dehydrating agents for the formation of imides from di­basic acids (e.g., 3- and/or 4) hydroxyphthalic acid with a large variety of diamines including diaminosiloxanes such as bis (3-aminopropyl)-tetra-methylsiloxane. Definition ChEBI: Succinimide is a dicarboximide that is pyrrolidine which is substituted by oxo groups at positions 2 and 5. It is a pyrrolidinone and a dicarboximide. Synthesis Reference(s) Journal of the American Chemical Society, 102, p. 7448, 1980 DOI: 10.1021/ja00545a009 Organic Syntheses, Coll. Vol. 2, p. 562, 1943 Chemical Synthesis Succinimide is obtained by the reaction of succinic acid with ammonia. Succinic acid and water are added into the reaction pot, and succinimide can be produced by ammonia reaction. Succinic acid can also be put into the reaction pot, drop ammonia, stir to dissolve and react, heat it to 102 ℃, evaporate the water, and then carry out vacuum distillation. When the temperature rises to 180 ℃, start collecting succinimide fraction to obtain the finished product. Purification Methods Crystallise the imide from EtOH (1mL/g) or water. [Beilstein 21 H 369, 21/9 V 438.]   Succinimide Preparation Products And Raw materials Raw materials Succinic acid-->2,5-Pyrrolidinedione, 1,1'-(dibutylstannylene)bis--->3-Bromopropionyl Isocyanate-->1,2-Dibromopentane-->Butanedioic acid, monoammonium salt-->Succinonitrile-->SUCCINAMIC ACID Preparation Products N-Bromosuccinimide-->N-Chlorosuccinimide-->β-Alanine-->Cilastatin-->N-Vinyl-2-pyrrolidone-->N-Iodosuccinimide-->3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE-->Dichloroacetonitrile-->Benzaldehyde, 2-bromo-5-methoxy-4-methyl--->Butanedihydrazid Product Name: Octadecanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)- Synonyms: Brn 3456035;N-((4-Hydroxy-3-methoxyphenyl)methyl)octadecanamide;Octadecanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-;N-(4-hydroxy-3-methoxybenzyl)octadecanamide;N-stearoylvanillylamide;STEAROYL VANILYLAMIDE;ctadecanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-;N-Vanillyloctadecanamide CAS: 58493-50-8 MF: C26H45NO3 MW: 419.64 EINECS:   Product Categories:   Mol File: 58493-50-8.mol   Octadecanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)- Chemical Properties Melting point  94.5-95 °C Boiling point  586.1±40.0 °C(Predicted) density  0.973±0.06 g/cm3(Predicted) pka 9.76±0.20(Predicted)   Safety Information MSDS Information   Octadecanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)- Usage And Synthesis