China Biggest Factory Manufacturer Supply D-ERYTHRO-SPHINGOSINE CAS 123-78-4 CAS NO.123-78-4

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D-ERYTHRO-SPHINGOSINE Basic information Product Name: D-ERYTHRO-SPHINGOSINE CAS: 123-78-4 MF: C18H37NO2 MW: 299.49 EINECS: 204-651-3 Product Categories: Amines;Protein Kinase;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators Mol File: 123-78-4.mol   D-ERYTHRO-SPHINGOSINE Chemical Properties Melting point  74.2-78.1 °C Boiling point  440.8°C (rough estimate) density  0.9758 (rough estimate) refractive index  1.5000 (estimate) storage temp.  -20°C solubility  chloroform: 20 mg/mL, clear, colorless to very faintly yellow form  Powder or Waxy Solid pka 11.80±0.45(Predicted) color  White to cream Merck  14,8747 BRN  1727294 Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents. InChIKey WWUZIQQURGPMPG-KRWOKUGFSA-N CAS DataBase Reference 123-78-4   Safety Information Safety Statements  22-24/25 WGK Germany  3 F  1-8-10 HS Code  29221985 MSDS Information Provider Language ACROS English SigmaAldrich English   D-ERYTHRO-SPHINGOSINE Usage And Synthesis Description Sphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4 Chemical Properties White Crystalline Solid Uses Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine Uses D-erythro-Sphingosine is used to inhibits protein kinase C and calmodulin-dependent enzymes, induces apoptosis. And also used to constituent of cell membranes. Uses Sphingosine (d18:1) has been used: for sphingosine inhalations studies in mice to evaluate its therapeutic potential in respiratory epithelial cells to investigate its effect on Pseudomonas aeruginosa strains as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides Definition cerebroside: Any one of a class ofglycolipids in which a single sugarunit is bound to a sphingolipid. The most commoncerebrosides are galactocerebrosides,containing the sugar group galactose;they are found in the plasma membranesof neural tissue and are abundantin the myelin sheaths ofneurones. General Description Sphingosine (d18:1) is a spingoid base present in plant and animals. It has 2-amino-1,3-diol functionality and its extraction from animal tissue is laborious. Sphingosine (d18:1) synthesis is performed by chirospecific method using D-galactose. Biological Activity Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C. Biochem/physiol Actions A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. Purification Methods D-Sphingosine is purified by recrystallisation from EtOAc, Et2O or pet ether (60-80o). It is insoluble in H2O but is soluble in Me2CO, EtOH and MeOH. It has IR bands at 1590 and 875 cm-1, and is characterised as the tribenzoate m 122-123o (from 95% EtOH). [Tipton Biochemical Preparations 9 127 1962.] References 1) Merrill et al., (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds; Biochemistry, 28 3138 2) Ohanian and Ohanian (2001) Sphingolipids in mammalian cell signaling; Cell. Mol. Life Science, 58 2053 3) Ruvolo (2003) Intracellular signal transduction pathways activated by ceramide and its metabolites; Pharm. Res., 47 383 4) Olivier (2002) Sphingosine in apoptosis signaling; Biochim. Biophys. Acta, 1585 153

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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D-ERYTHRO-SPHINGOSINE Basic information Product Name: D-ERYTHRO-SPHINGOSINE CAS: 123-78-4 MF: C18H37NO2 MW: 299.49 EINECS: 204-651-3 Product Categories: Amines;Protein Kinase;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators Mol File: 123-78-4.mol   D-ERYTHRO-SPHINGOSINE Chemical Properties Melting point  74.2-78.1 °C Boiling point  440.8°C (rough estimate) density  0.9758 (rough estimate) refractive index  1.5000 (estimate) storage temp.  -20°C solubility  chloroform: 20 mg/mL, clear, colorless to very faintly yellow form  Powder or Waxy Solid pka 11.80±0.45(Predicted) color  White to cream Merck  14,8747 BRN  1727294 Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents. InChIKey WWUZIQQURGPMPG-KRWOKUGFSA-N CAS DataBase Reference 123-78-4   Safety Information Safety Statements  22-24/25 WGK Germany  3 F  1-8-10 HS Code  29221985 MSDS Information Provider Language ACROS English SigmaAldrich English   D-ERYTHRO-SPHINGOSINE Usage And Synthesis Description Sphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4 Chemical Properties White Crystalline Solid Uses Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine Uses D-erythro-Sphingosine is used to inhibits protein kinase C and calmodulin-dependent enzymes, induces apoptosis. And also used to constituent of cell membranes. Uses Sphingosine (d18:1) has been used: for sphingosine inhalations studies in mice to evaluate its therapeutic potential in respiratory epithelial cells to investigate its effect on Pseudomonas aeruginosa strains as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides Definition cerebroside: Any one of a class ofglycolipids in which a single sugarunit is bound to a sphingolipid. The most commoncerebrosides are galactocerebrosides,containing the sugar group galactose;they are found in the plasma membranesof neural tissue and are abundantin the myelin sheaths ofneurones. General Description Sphingosine (d18:1) is a spingoid base present in plant and animals. It has 2-amino-1,3-diol functionality and its extraction from animal tissue is laborious. Sphingosine (d18:1) synthesis is performed by chirospecific method using D-galactose. Biological Activity Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C. Biochem/physiol Actions A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. Purification Methods D-Sphingosine is purified by recrystallisation from EtOAc, Et2O or pet ether (60-80o). It is insoluble in H2O but is soluble in Me2CO, EtOH and MeOH. It has IR bands at 1590 and 875 cm-1, and is characterised as the tribenzoate m 122-123o (from 95% EtOH). [Tipton Biochemical Preparations 9 127 1962.] References 1) Merrill et al., (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds; Biochemistry, 28 3138 2) Ohanian and Ohanian (2001) Sphingolipids in mammalian cell signaling; Cell. Mol. Life Science, 58 2053 3) Ruvolo (2003) Intracellular signal transduction pathways activated by ceramide and its metabolites; Pharm. Res., 47 383 4) Olivier (2002) Sphingosine in apoptosis signaling; Biochim. Biophys. Acta, 1585 153