China Biggest Manufacturer factory sales FERROUS FUMERATE CAS 141-01-5 CAS NO.141-01-5

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Ferrous fumarate Basic information Uses Product Name: Ferrous fumarate Synonyms: Iron(Ⅱ) fumarate;Iron(II) fuMarate >=97.0%;IR microencapsulated Ferrous fumarate;Ferrius fumarate;IRON(II) FUMARATE;IRON(+2)FUMARATE;IRON FUMARATE;FERROUS FUMARATE CAS: 141-01-5 MF: C4H2FeO4 MW: 169.9 EINECS: 205-447-7 Product Categories: Pharmaceutical intermediates;Pharmacopoeia (USP);Carbonyl Compounds;Carboxylic Acid Salts;Organic Building Blocks;Pharmacopoeia A-Z;Organic-metal salt;VX:15689727968 Mol File: 141-01-5.mol   Ferrous fumarate Chemical Properties Melting point  >280°C density  2.435 storage temp.  Refrigerator solubility  Slightly soluble in water, very slightly soluble in ethanol (96 per cent). form  solid color  Dark Red to Dark Brown Water Solubility  Soluble in water (0.14 g/100 ml at 25°C). Merck  14,4046 Stability: Stability InChIKey PMVSDNDAUGGCCE-TYYBGVCCSA-L CAS DataBase Reference 141-01-5(CAS DataBase Reference) EPA Substance Registry System 2-Butenedioic acid (2E)-, iron(2+) salt (1:1) (141-01-5)   Safety Information Risk Statements  36/37/38 Safety Statements  22-36/37/39-24/25 WGK Germany  2 RTECS  LT1950000 TSCA  Yes HS Code  29171900 Toxicity LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum) MSDS Information Provider Language Iron(II) fumarate English ALFA English   Ferrous fumarate Usage And Synthesis Uses Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles. Description Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort. Chemical Properties brown to reddish-brown powder Chemical Properties §184.1307d(a) Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate. Originator Toleron,Mallinckrodt Inc.,US,1957 Uses Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency. Uses Ferrous Fumarate is a reddish orange to red-brown powder that is a source of iron. it has high bioavailability and can be used in foods where the red color can be masked. it contains approximately 33% iron. it is used as a dietary supplement in breakfast cereals, poultry stuffing, enriched flour, and instant drinks. Uses Iron(II) fumarate is used as dietary Supplement, nutrient, iron source in foods and pharmaceuticals, as animal feed additive and in infant formulas. Definition Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubl Manufacturing Process Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to 45 gallons) and fumaric acid (50 pounds) was added slowly. During the addition the solution was stirred and heated. The resulting solution of sodium fumarate, having a pH of 6.8, was added slowly with mixing to a solution of ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH of 3.3, both solutions being maintained at or near boiling temperature during the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate was filtered and washed in a centrifuge and dried in a tray drier (15 hours at 110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe, 32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found. Therapeutic Function Hematinic General Description Ferrous fumarate is a commonly used inexpensive substitute for other forms of iron, that is employed as a food iron fortificant. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Clinical Use Iron deficiency anaemia Safety Profile Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID. Drug interactions Potentially hazardous interactions with other drugs Antibacterials: reduced absorption of 4-quinolones and tetracyclines. Dimercaprol: avoid concomitant use. Mycophenolate: may significantly reduce absorption of mycophenolate. Metabolism Molecular weight (daltons) 169.9 % Protein binding - % Excreted unchanged in urine - Volume of distribution (L/kg) - Half-life - normal/ESRF (hrs) - References Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795. Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.   Ferrous fumarate Preparation Products And Raw materials Raw materials Ferrous sulfate heptahydrate-->Fumaric acid-->Disodium fumarate-->Sodium carbonate-->Ferric sulfate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Ferrous fumarate Basic information Uses Product Name: Ferrous fumarate Synonyms: Iron(Ⅱ) fumarate;Iron(II) fuMarate >=97.0%;IR microencapsulated Ferrous fumarate;Ferrius fumarate;IRON(II) FUMARATE;IRON(+2)FUMARATE;IRON FUMARATE;FERROUS FUMARATE CAS: 141-01-5 MF: C4H2FeO4 MW: 169.9 EINECS: 205-447-7 Product Categories: Pharmaceutical intermediates;Pharmacopoeia (USP);Carbonyl Compounds;Carboxylic Acid Salts;Organic Building Blocks;Pharmacopoeia A-Z;Organic-metal salt;VX:15689727968 Mol File: 141-01-5.mol   Ferrous fumarate Chemical Properties Melting point  >280°C density  2.435 storage temp.  Refrigerator solubility  Slightly soluble in water, very slightly soluble in ethanol (96 per cent). form  solid color  Dark Red to Dark Brown Water Solubility  Soluble in water (0.14 g/100 ml at 25°C). Merck  14,4046 Stability: Stability InChIKey PMVSDNDAUGGCCE-TYYBGVCCSA-L CAS DataBase Reference 141-01-5(CAS DataBase Reference) EPA Substance Registry System 2-Butenedioic acid (2E)-, iron(2+) salt (1:1) (141-01-5)   Safety Information Risk Statements  36/37/38 Safety Statements  22-36/37/39-24/25 WGK Germany  2 RTECS  LT1950000 TSCA  Yes HS Code  29171900 Toxicity LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum) MSDS Information Provider Language Iron(II) fumarate English ALFA English   Ferrous fumarate Usage And Synthesis Uses Iron(II) Fumarate is a a chemical used in the treatment of iron deficiency. More commonly used for this treatment is Ferrous Sulfate however Iron(II) Fumarate does maintain similar absorption profiles. Description Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort. Chemical Properties brown to reddish-brown powder Chemical Properties §184.1307d(a) Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate. Originator Toleron,Mallinckrodt Inc.,US,1957 Uses Ferrous fumarate is available as a syrup and may be useful in small children for the treatment and prophylaxis of iron deficiency. Uses Ferrous Fumarate is a reddish orange to red-brown powder that is a source of iron. it has high bioavailability and can be used in foods where the red color can be masked. it contains approximately 33% iron. it is used as a dietary supplement in breakfast cereals, poultry stuffing, enriched flour, and instant drinks. Uses Iron(II) fumarate is used as dietary Supplement, nutrient, iron source in foods and pharmaceuticals, as animal feed additive and in infant formulas. Definition Anhydrous salt of a combination of ferrous iron and fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains 33% iron by weight, does not melt at temperatures up to 280C, insoluble in alcohol, very slightly solubl Manufacturing Process Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to 45 gallons) and fumaric acid (50 pounds) was added slowly. During the addition the solution was stirred and heated. The resulting solution of sodium fumarate, having a pH of 6.8, was added slowly with mixing to a solution of ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH of 3.3, both solutions being maintained at or near boiling temperature during the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate was filtered and washed in a centrifuge and dried in a tray drier (15 hours at 110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe, 32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found. Therapeutic Function Hematinic General Description Ferrous fumarate is a commonly used inexpensive substitute for other forms of iron, that is employed as a food iron fortificant. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Clinical Use Iron deficiency anaemia Safety Profile Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: dyspnea, nausea or vomiting, somnolence. When heated to decomposition it emits acrid smoke and irritating fumes. See also FUMRIC ACID. Drug interactions Potentially hazardous interactions with other drugs Antibacterials: reduced absorption of 4-quinolones and tetracyclines. Dimercaprol: avoid concomitant use. Mycophenolate: may significantly reduce absorption of mycophenolate. Metabolism Molecular weight (daltons) 169.9 % Protein binding - % Excreted unchanged in urine - Volume of distribution (L/kg) - Half-life - normal/ESRF (hrs) - References Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795. Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303.   Ferrous fumarate Preparation Products And Raw materials Raw materials Ferrous sulfate heptahydrate-->Fumaric acid-->Disodium fumarate-->Sodium carbonate-->Ferric sulfate