China Largest Manufacturer factory sales L-Proline CAS 147-85-3 CAS NO.147-85-3

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L-Proline Basic information Product Name: L-Proline Synonyms: L-Proline ,L-2-Pyrrolidinecarboxylic acid;L-PROLINE, NATURAL;L-PROLINE, SYNTHETIC;L-(-)-PROLINE ((S)-(-)-PROLINE);L-PROLINE (13C5, 99%);L-PROLINE (13C5, 99%;L-PROLINE (D7, 97-98%);L(-)-Proline 0 CAS: 147-85-3 MF: C5H9NO2 MW: 115.13 EINECS: 205-702-2 Product Categories: amino;Amino Acids;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Food & Feed ADDITIVES;Amino Acid Derivatives;Proline [Pro, P];Amino Acids;Amino Acids and Derivatives Mol File: 147-85-3.mol   L-Proline Chemical Properties Melting point  228 °C (dec.) (lit.) alpha  -85.5 º (c=4, H2O) Boiling point  215.41°C (rough estimate) density  1.35 FEMA  3319 | L-PROLINE refractive index  -85 ° (C=4, H2O) storage temp.  2-8°C solubility  H2O: 50 mg/mL pka 1.95, 10.64(at 25℃) form  powder color  White PH 6.0-7.0 (25℃, 1M in H2O) optical activity [α]20/D 85.0±1.0°, c = 5% in H2O Water Solubility  soluble λmax λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05 Sensitive  Hygroscopic JECFA Number 1425 Merck  14,7780 BRN  80810 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey ONIBWKKTOPOVIA-UHFFFAOYSA-N CAS DataBase Reference 147-85-3(CAS DataBase Reference) NIST Chemistry Reference Proline(147-85-3) EPA Substance Registry System L-Proline (147-85-3)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  24/25-36/37/39-26 WGK Germany  3 RTECS  TW3584000 F  3-10 TSCA  Yes HS Code  29339990 Hazardous Substances Data 147-85-3(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: > 5110 mg/kg MSDS Information Provider Language 2-Pyrrolidinecarboxylic acid English ACROS English SigmaAldrich English ALFA English   L-Proline Usage And Synthesis Chemical Properties White crystalline powder Chemical Properties L-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste. Occurrence Reported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue. Uses L-Proline is used as asymmetric catalysts in organic synthesis and asymmetric aldol cyclization. It is involved in the Michael addition of dimethyl malonate to alfa-beta-unsaturated aldehydes. It is a precursor of hydroxyproline in collagen. It is an active component of collagen and involved in the proper functioning of joints and tendons. It finds uses in pharmaceutical, biotechnological applications due to its osmoprotectant property. Further, it is used with ninhydrin in the chromatography. Uses amino acid, nutrient Uses L-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing. Preparation From α-piperidone; from cyclopentantone; from l-glutamic acid. General Description L-Proline is a non-essential amino acid. Peptides bond to proline, making it a useful building block for proteins. It can be used as a cell culture media component for the commercial biomanufacturing of therapeutic recombinant proteins and monoclonal antibodies. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions Proline is a cyclic, non-essential, hydrophobic amino acid. It is a proteinogenic amino acid which is crucial for primary metabolism. In peptide chains, proline residues confer structural constraints and enhance the susceptibility of proximal peptide bonds to protease activity. Purification Methods A likely impurity is hydroxyproline. Purify L-proline via its picrate which is crystallised twice from water, then decomposed with 40% H2SO4. The picric acid is extracted with diethyl ether, the H2SO4 in solution is precipitated with Ba(OH)2, and the filtrate is evaporated. The residue is crystallised from hot absolute EtOH [Mellan & Hoover J Am Chem Soc 73 3879 1951] or EtOH/Et2O. Its solubility in H2O is >100%. It sublimes at 182-187o/0.3mm with 99.4% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. It is hygroscopic and is stored in a desiccator. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2178-2199 1961, Beilstein 22 III/IV 8, 22/1 V 31.]   L-Proline Preparation Products And Raw materials Raw materials Triethylamine-->Ammonium chloride-->Isopropyl alcohol-->Aluminum oxide-->D(+)-Glucose-->Triethanolamine-->Potassium borohydride-->L-Glutamic acid-->Casein-->Gelatin-->PICRIC ACID Preparation Products 2-(2-Aminoethyl)-1-methylpyrrolidine-->Enalapril-->Captopril-->Levosulpiride-->(S)-2-Methylproline-->(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole-->2-Fluoro-4-(methylsulfonyl)aniline-->(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol-->D-Proline-->Lisinopril-->D-(S)-3-acetylthio-2-methylpropionylL-proline-->R(-)-DENOPAMINE-->DL-Proline-->Methyl L-prolinate hydrochloride-->(2S)-1-Methyl-2-Pyrrolidineethanol-->2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI)-->Z-PRO-NH2

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-Proline Basic information Product Name: L-Proline Synonyms: L-Proline ,L-2-Pyrrolidinecarboxylic acid;L-PROLINE, NATURAL;L-PROLINE, SYNTHETIC;L-(-)-PROLINE ((S)-(-)-PROLINE);L-PROLINE (13C5, 99%);L-PROLINE (13C5, 99%;L-PROLINE (D7, 97-98%);L(-)-Proline 0 CAS: 147-85-3 MF: C5H9NO2 MW: 115.13 EINECS: 205-702-2 Product Categories: amino;Amino Acids;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Food & Feed ADDITIVES;Amino Acid Derivatives;Proline [Pro, P];Amino Acids;Amino Acids and Derivatives Mol File: 147-85-3.mol   L-Proline Chemical Properties Melting point  228 °C (dec.) (lit.) alpha  -85.5 º (c=4, H2O) Boiling point  215.41°C (rough estimate) density  1.35 FEMA  3319 | L-PROLINE refractive index  -85 ° (C=4, H2O) storage temp.  2-8°C solubility  H2O: 50 mg/mL pka 1.95, 10.64(at 25℃) form  powder color  White PH 6.0-7.0 (25℃, 1M in H2O) optical activity [α]20/D 85.0±1.0°, c = 5% in H2O Water Solubility  soluble λmax λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05 Sensitive  Hygroscopic JECFA Number 1425 Merck  14,7780 BRN  80810 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey ONIBWKKTOPOVIA-UHFFFAOYSA-N CAS DataBase Reference 147-85-3(CAS DataBase Reference) NIST Chemistry Reference Proline(147-85-3) EPA Substance Registry System L-Proline (147-85-3)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  24/25-36/37/39-26 WGK Germany  3 RTECS  TW3584000 F  3-10 TSCA  Yes HS Code  29339990 Hazardous Substances Data 147-85-3(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: > 5110 mg/kg MSDS Information Provider Language 2-Pyrrolidinecarboxylic acid English ACROS English SigmaAldrich English ALFA English   L-Proline Usage And Synthesis Chemical Properties White crystalline powder Chemical Properties L-Proline, an amino acid, is odorless or has a slight, characteristic odor with a slightly sweet taste. Occurrence Reported found as a component in many proteins; also widely occurring as the free acid in natural products. A major constituent of collagen, the main fibrous protein found in bone, cartilage and other connective tissue. Uses L-Proline is used as asymmetric catalysts in organic synthesis and asymmetric aldol cyclization. It is involved in the Michael addition of dimethyl malonate to alfa-beta-unsaturated aldehydes. It is a precursor of hydroxyproline in collagen. It is an active component of collagen and involved in the proper functioning of joints and tendons. It finds uses in pharmaceutical, biotechnological applications due to its osmoprotectant property. Further, it is used with ninhydrin in the chromatography. Uses amino acid, nutrient Uses L-Proline is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing. Preparation From α-piperidone; from cyclopentantone; from l-glutamic acid. General Description L-Proline is a non-essential amino acid. Peptides bond to proline, making it a useful building block for proteins. It can be used as a cell culture media component for the commercial biomanufacturing of therapeutic recombinant proteins and monoclonal antibodies. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions Proline is a cyclic, non-essential, hydrophobic amino acid. It is a proteinogenic amino acid which is crucial for primary metabolism. In peptide chains, proline residues confer structural constraints and enhance the susceptibility of proximal peptide bonds to protease activity. Purification Methods A likely impurity is hydroxyproline. Purify L-proline via its picrate which is crystallised twice from water, then decomposed with 40% H2SO4. The picric acid is extracted with diethyl ether, the H2SO4 in solution is precipitated with Ba(OH)2, and the filtrate is evaporated. The residue is crystallised from hot absolute EtOH [Mellan & Hoover J Am Chem Soc 73 3879 1951] or EtOH/Et2O. Its solubility in H2O is >100%. It sublimes at 182-187o/0.3mm with 99.4% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. It is hygroscopic and is stored in a desiccator. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2178-2199 1961, Beilstein 22 III/IV 8, 22/1 V 31.]   L-Proline Preparation Products And Raw materials Raw materials Triethylamine-->Ammonium chloride-->Isopropyl alcohol-->Aluminum oxide-->D(+)-Glucose-->Triethanolamine-->Potassium borohydride-->L-Glutamic acid-->Casein-->Gelatin-->PICRIC ACID Preparation Products 2-(2-Aminoethyl)-1-methylpyrrolidine-->Enalapril-->Captopril-->Levosulpiride-->(S)-2-Methylproline-->(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole-->2-Fluoro-4-(methylsulfonyl)aniline-->(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol-->D-Proline-->Lisinopril-->D-(S)-3-acetylthio-2-methylpropionylL-proline-->R(-)-DENOPAMINE-->DL-Proline-->Methyl L-prolinate hydrochloride-->(2S)-1-Methyl-2-Pyrrolidineethanol-->2-Pyrrolidinecarboxamide,1-(hydroxyacetyl)-,(S)-(9CI)-->Z-PRO-NH2