China Largest Manufacturer factory sales 4-Aminobenzoic acid CAS 150-13-0 CAS NO.150-13-0

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4-Aminobenzoic acid Basic information Product Name: 4-Aminobenzoic acid Synonyms: 4-AMinobenzoic acid ReagentPlus(R), >=99%;4-AMinobenzoic acid ReagentPlus(R), 99%;4-AMinobenzoic Acid, 97+%;The aMino acid;Conivaptan hydrochkoride Impurity B;Folic acid Impurity;4-carboxyanilin;4-Aminobenzoic acid purified by sublimation, >=99% CAS: 150-13-0 MF: C7H7NO2 MW: 137.14 EINECS: 205-753-0 Product Categories: Amines;Aromatics;AMINOACID;Benzene derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Anilines (Building Blocks for Liquid Crystals);Benzoic Acids (Building Blocks for Liquid Crystals);Bifunctional Compounds (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Pharmaceutical intermediates;amine | carboxylic acid;NEXIUM;buildingblock;Intermediate;150-13-0 Mol File: 150-13-0.mol   4-Aminobenzoic acid Chemical Properties Melting point  187-189 °C(lit.) Boiling point  251.96°C (rough estimate) density  1.374 g/mL at 25 °C(lit.) refractive index  1.5323 (estimate) Fp  250 °C storage temp.  2-8°C solubility  95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow form  Crystalline Powder pka 2.50, 4.87(at 25℃) color  White to light yellow Odor Odorless PH 3.5 (5g/l, H2O, 20℃) PH Range 3.5 Water Solubility  4.7 g/L (20 ºC) Sensitive  Air & Light Sensitive Merck  14,423 BRN  471605 Stability: Stable. Incompatible with strong oxidizing agents. Combustible. Sensitive to light and air. May discolour on exposure to light. InChIKey ALYNCZNDIQEVRV-UHFFFAOYSA-N CAS DataBase Reference 150-13-0(CAS DataBase Reference) IARC 3 (Vol. 16, Sup 7) 1987 NIST Chemistry Reference p-Aminobenzoic acid(150-13-0) EPA Substance Registry System p-Aminobenzoic acid (150-13-0)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-43 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  DG1400000 TSCA  Yes HS Code  29224995 Hazardous Substances Data 150-13-0(Hazardous Substances Data) Toxicity LD50 in mice, rats (g/kg): 2.85, >6.0 orally (Scott, Robbins); LD50 in rabbits (g/kg): 2.0 i.v. (Richards); 1.83 orally (Cronheim) MSDS Information Provider Language 1-Amino-4-carboxybenzene English SigmaAldrich English ACROS English ALFA English   4-Aminobenzoic acid Usage And Synthesis Description 4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position) is an organic compound with the formula H2NC6H4CO2H. PABA is a white solid, although commercial samples can appear gray. It is slightly soluble in water. It consists of a benzene ring substituted with amino and a carboxyl groups. The compound occurs naturally. The potassium salt is used as a drug against fibrotic skin disorders, such as Peyronie's disease, under the trade name Potaba. PABA is also occasionally used in pill form by sufferers of irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels. Chemical Properties colorless needle-like crystals. turns light yellow in the air or in light. Soluble in hot water, ether, ethyl acetate, ethanol and glacial acetic acid, insoluble in water, benzene, and insoluble in petroleum ether. Originator Pabalate,Robins,US,1949 Uses 4-aminobenzoic acid is an aminobenzoic acid isomer that combines with pteridine and glutamic acid to folic acid. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in sunscreens. Also it is used as a component of some medicines e.g analgesic or anesthetic preparations sunscreen agents and bentiromide. Definition ChEBI: 4-aminobenzoic acid is an aminobenzoic acid in which the amino group is para to the carboxy group. It has a role as an Escherichia coli metabolite, a plant metabolite and an allergen. It derives from a benzoic acid. It is a conjugate acid of a 4-aminobenzoate. Preparation 4-Aminobenzoic acid synthesis method: add 38.0g of p-nitrobenzoic acid, 200mL of water, 20mL of tetrahydrofuran, 0.4g of sodium dodecyl sulfonate and 1.9g of Raney nickel to the autoclave, nitrogen replacement Three times, fill with hydrogen, adjust the pressure to 0.9±0.1MPa, adjust the temperature to 100±2°C, and keep the reaction under pressure for 4h to complete. After the reaction, the catalyst was recovered by filtration, left to stand for stratification, the water layer was directly applied mechanically, the tetrahydrofuran layer was distilled and recovered and applied mechanically, then 1.5 g of activated carbon was added to the 4-aminobenzoic acid mother liquor, and under nitrogen protection, heating and refluxing for decolorization for 20min, Filtration, cooling and crystallization of mother liquor, filtration, drying under vacuum at 80-85 °C to obtain 30.3 g of 4-aminobenzoic acid with a yield of 97.2%, a melting point of 187.1-187.6 °C, and a content of 100.2% (permanent stop titration method) . Brand name RVPaba Lipstick (ICN). Therapeutic Function Sunscreen agent, Antirickettsial Biological Functions 4-Aminobenzoic acid is one of the most important aromatic amino acids. It is an important part of the substances necessary for the growth and division of body cells. It has an irreplaceable role in the metabolism of life. It is used in yeast, liver, bran and malt. The content is very high. 4-Aminobenzoic acid can relieve anemia caused by lack of red blood cells, viral anemia, sprue and anemia during pregnancy. 4-Aminobenzoic acid is a high-efficiency nutritional product with the main ingredient - vitamin B-100, which can effectively improve the three major metabolisms of the human body, comprehensively combat fatigue and relieve stress. The compatibility of 4-aminobenzoic acid with penicillin or streptomycin can effectively improve the bacteriostatic effect. Synthesis Reference(s) Synthesis, p. 285, 1971 Tetrahedron, 47, p. 8587, 1991 DOI: 10.1016/S0040-4020(01)82402-9 General Description Colorless crystals that discolor on exposure to light and air. Reactivity Profile 4-Aminobenzoic acid is incompatible with ferric salts and oxidizing agents. Hazard Questionable carcinogen. Safety Profile Moderately toxic by ingestion and intravenous routes. Ingesting large doses can cause nausea, vomiting, skin rash, methemoglobinemia, and possibly toxic hepatitis. Experimental reproductive effects. Mutation data reported. Questionable carcinogen. Combustible. When heated to decomposition it emits toxic fumes of NO,. A topical sunscreen. Purification Methods Purify p-aminobenzoic acid by dissolving it in 4-5% aqueous HCl at 50-60o, decolorising with charcoal and carefully precipitating it with 30% Na2CO3 to pH 3.5-4 in the presence of ascorbic acid. It can be recrystallised from water, EtOH or EtOH/water mixtures. [Beilstein 14 IV 1126.]   4-Aminobenzoic acid Preparation Products And Raw materials Raw materials Sodium dithionite-->p-Nitrobenzoic acid-->Ammonium sulfate-->Sodium hypochlorite-->Xylene Preparation Products Ampicillin-->6-Quinolinylmethanol-->METHYL 4-METHYLAMINOBENZOATE-->2,6-Dichloroaniline-->Methyl 4-aminobenzoate-->N10-(TRIFLUOROACETYL)PTEROIC ACID-->4-(ETHYLTHIO)BENZOIC ACID-->4-ACETAMIDOBENZOYL CHLORIDE-->Methyl Orange-->Reactive Red Brown K-B3r-->2-Methyl-6-quinolinecarboxylic acid-->Benzocaine-->4-(Aminomethyl)benzoic acid-->4-Cyanobenzoic acid-->Disperse Yellow 126-->6-Quinolinecarboxylic acid-->2,5-BIS(4-AMINOPHENYL)-1,3,4-OXADIAZOLE-->4-CARBOXYPHENYL ISOTHIOCYANATE-->4-(1H-PYRROL-1-YL)BENZOIC ACID-->4-(METHANESULFONYLAMINO)BENZOIC ACID-->Butyl 4-aminobenzoate-->C.I.Reactive Red 11-->p-Acetylamino benzoic acid-->N-Formyl-4-(methylamino)benzoic acid-->4-Iodobenzoic acid-->4-(N-Formyl-N-methyl)aminobenzoyl chloride Tag:4-Aminobenzoic acid(150-13-0) Related Product Information

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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4-Aminobenzoic acid Basic information Product Name: 4-Aminobenzoic acid Synonyms: 4-AMinobenzoic acid ReagentPlus(R), >=99%;4-AMinobenzoic acid ReagentPlus(R), 99%;4-AMinobenzoic Acid, 97+%;The aMino acid;Conivaptan hydrochkoride Impurity B;Folic acid Impurity;4-carboxyanilin;4-Aminobenzoic acid purified by sublimation, >=99% CAS: 150-13-0 MF: C7H7NO2 MW: 137.14 EINECS: 205-753-0 Product Categories: Amines;Aromatics;AMINOACID;Benzene derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids;Anilines (Building Blocks for Liquid Crystals);Benzoic Acids (Building Blocks for Liquid Crystals);Bifunctional Compounds (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Pharmaceutical intermediates;amine | carboxylic acid;NEXIUM;buildingblock;Intermediate;150-13-0 Mol File: 150-13-0.mol   4-Aminobenzoic acid Chemical Properties Melting point  187-189 °C(lit.) Boiling point  251.96°C (rough estimate) density  1.374 g/mL at 25 °C(lit.) refractive index  1.5323 (estimate) Fp  250 °C storage temp.  2-8°C solubility  95% ethanol: soluble5%, clear to slightly hazy, colorless to yellow form  Crystalline Powder pka 2.50, 4.87(at 25℃) color  White to light yellow Odor Odorless PH 3.5 (5g/l, H2O, 20℃) PH Range 3.5 Water Solubility  4.7 g/L (20 ºC) Sensitive  Air & Light Sensitive Merck  14,423 BRN  471605 Stability: Stable. Incompatible with strong oxidizing agents. Combustible. Sensitive to light and air. May discolour on exposure to light. InChIKey ALYNCZNDIQEVRV-UHFFFAOYSA-N CAS DataBase Reference 150-13-0(CAS DataBase Reference) IARC 3 (Vol. 16, Sup 7) 1987 NIST Chemistry Reference p-Aminobenzoic acid(150-13-0) EPA Substance Registry System p-Aminobenzoic acid (150-13-0)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-43 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  DG1400000 TSCA  Yes HS Code  29224995 Hazardous Substances Data 150-13-0(Hazardous Substances Data) Toxicity LD50 in mice, rats (g/kg): 2.85, >6.0 orally (Scott, Robbins); LD50 in rabbits (g/kg): 2.0 i.v. (Richards); 1.83 orally (Cronheim) MSDS Information Provider Language 1-Amino-4-carboxybenzene English SigmaAldrich English ACROS English ALFA English   4-Aminobenzoic acid Usage And Synthesis Description 4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position) is an organic compound with the formula H2NC6H4CO2H. PABA is a white solid, although commercial samples can appear gray. It is slightly soluble in water. It consists of a benzene ring substituted with amino and a carboxyl groups. The compound occurs naturally. The potassium salt is used as a drug against fibrotic skin disorders, such as Peyronie's disease, under the trade name Potaba. PABA is also occasionally used in pill form by sufferers of irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels. Chemical Properties colorless needle-like crystals. turns light yellow in the air or in light. Soluble in hot water, ether, ethyl acetate, ethanol and glacial acetic acid, insoluble in water, benzene, and insoluble in petroleum ether. Originator Pabalate,Robins,US,1949 Uses 4-aminobenzoic acid is an aminobenzoic acid isomer that combines with pteridine and glutamic acid to folic acid. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in sunscreens. Also it is used as a component of some medicines e.g analgesic or anesthetic preparations sunscreen agents and bentiromide. Definition ChEBI: 4-aminobenzoic acid is an aminobenzoic acid in which the amino group is para to the carboxy group. It has a role as an Escherichia coli metabolite, a plant metabolite and an allergen. It derives from a benzoic acid. It is a conjugate acid of a 4-aminobenzoate. Preparation 4-Aminobenzoic acid synthesis method: add 38.0g of p-nitrobenzoic acid, 200mL of water, 20mL of tetrahydrofuran, 0.4g of sodium dodecyl sulfonate and 1.9g of Raney nickel to the autoclave, nitrogen replacement Three times, fill with hydrogen, adjust the pressure to 0.9±0.1MPa, adjust the temperature to 100±2°C, and keep the reaction under pressure for 4h to complete. After the reaction, the catalyst was recovered by filtration, left to stand for stratification, the water layer was directly applied mechanically, the tetrahydrofuran layer was distilled and recovered and applied mechanically, then 1.5 g of activated carbon was added to the 4-aminobenzoic acid mother liquor, and under nitrogen protection, heating and refluxing for decolorization for 20min, Filtration, cooling and crystallization of mother liquor, filtration, drying under vacuum at 80-85 °C to obtain 30.3 g of 4-aminobenzoic acid with a yield of 97.2%, a melting point of 187.1-187.6 °C, and a content of 100.2% (permanent stop titration method) . Brand name RVPaba Lipstick (ICN). Therapeutic Function Sunscreen agent, Antirickettsial Biological Functions 4-Aminobenzoic acid is one of the most important aromatic amino acids. It is an important part of the substances necessary for the growth and division of body cells. It has an irreplaceable role in the metabolism of life. It is used in yeast, liver, bran and malt. The content is very high. 4-Aminobenzoic acid can relieve anemia caused by lack of red blood cells, viral anemia, sprue and anemia during pregnancy. 4-Aminobenzoic acid is a high-efficiency nutritional product with the main ingredient - vitamin B-100, which can effectively improve the three major metabolisms of the human body, comprehensively combat fatigue and relieve stress. The compatibility of 4-aminobenzoic acid with penicillin or streptomycin can effectively improve the bacteriostatic effect. Synthesis Reference(s) Synthesis, p. 285, 1971 Tetrahedron, 47, p. 8587, 1991 DOI: 10.1016/S0040-4020(01)82402-9 General Description Colorless crystals that discolor on exposure to light and air. Reactivity Profile 4-Aminobenzoic acid is incompatible with ferric salts and oxidizing agents. Hazard Questionable carcinogen. Safety Profile Moderately toxic by ingestion and intravenous routes. Ingesting large doses can cause nausea, vomiting, skin rash, methemoglobinemia, and possibly toxic hepatitis. Experimental reproductive effects. Mutation data reported. Questionable carcinogen. Combustible. When heated to decomposition it emits toxic fumes of NO,. A topical sunscreen. Purification Methods Purify p-aminobenzoic acid by dissolving it in 4-5% aqueous HCl at 50-60o, decolorising with charcoal and carefully precipitating it with 30% Na2CO3 to pH 3.5-4 in the presence of ascorbic acid. It can be recrystallised from water, EtOH or EtOH/water mixtures. [Beilstein 14 IV 1126.]   4-Aminobenzoic acid Preparation Products And Raw materials Raw materials Sodium dithionite-->p-Nitrobenzoic acid-->Ammonium sulfate-->Sodium hypochlorite-->Xylene Preparation Products Ampicillin-->6-Quinolinylmethanol-->METHYL 4-METHYLAMINOBENZOATE-->2,6-Dichloroaniline-->Methyl 4-aminobenzoate-->N10-(TRIFLUOROACETYL)PTEROIC ACID-->4-(ETHYLTHIO)BENZOIC ACID-->4-ACETAMIDOBENZOYL CHLORIDE-->Methyl Orange-->Reactive Red Brown K-B3r-->2-Methyl-6-quinolinecarboxylic acid-->Benzocaine-->4-(Aminomethyl)benzoic acid-->4-Cyanobenzoic acid-->Disperse Yellow 126-->6-Quinolinecarboxylic acid-->2,5-BIS(4-AMINOPHENYL)-1,3,4-OXADIAZOLE-->4-CARBOXYPHENYL ISOTHIOCYANATE-->4-(1H-PYRROL-1-YL)BENZOIC ACID-->4-(METHANESULFONYLAMINO)BENZOIC ACID-->Butyl 4-aminobenzoate-->C.I.Reactive Red 11-->p-Acetylamino benzoic acid-->N-Formyl-4-(methylamino)benzoic acid-->4-Iodobenzoic acid-->4-(N-Formyl-N-methyl)aminobenzoyl chloride Tag:4-Aminobenzoic acid(150-13-0) Related Product Information