China Original Largest Manufacturer sales Methoxycarbonyl-L-tert-leucine CAS 162537-11-3 CAS NO.162537-11-3

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Methoxycarbonyl-L-tert-leucine Basic information Description References Product Name: Methoxycarbonyl-L-tert-leucine Synonyms: MOC-L-tert.Leucine;(S)-2-Methoxycarbonylamino-3,3-dimethylbutyric acid;Methoxycarbonyl-L-tert-leucine;N-(Methoxycarbonyl)-3-methyl-L-valine;N-Methoxycarbonyl-tert-leucine;Atazanavir related coMpound A;MOC-L-tert. Leucin;L-Valine,N-(Methoxycarbonyl)-3-Methyl- CAS: 162537-11-3 MF: C8H15NO4 MW: 189.21 EINECS: 1308068-626-2 Product Categories: Amino Acid Derivatives;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents Mol File: 162537-11-3.mol   Methoxycarbonyl-L-tert-leucine Chemical Properties Melting point  1090C Boiling point  320.9±25.0 °C(Predicted) density  1.126±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  Soluble in ethyl acetate and methanol. pka 4.46±0.10(Predicted) form  powder InChIKey NWPRXAIYBULIEI-RXMQYKEDSA-N   Safety Information HS Code  2933399090 MSDS Information   Methoxycarbonyl-L-tert-leucine Usage And Synthesis Description Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate.  References Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328. Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016). # q=14328-63-3 Chemical Properties White Solid Uses The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.   Methoxycarbonyl-L-tert-leucine Preparation Products And Raw materials Raw materials N-Boc-L-tert-Leucine-->Methyl chloroformate-->L-tert-Leucine Preparation Products Atazanavir

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Methoxycarbonyl-L-tert-leucine Basic information Description References Product Name: Methoxycarbonyl-L-tert-leucine Synonyms: MOC-L-tert.Leucine;(S)-2-Methoxycarbonylamino-3,3-dimethylbutyric acid;Methoxycarbonyl-L-tert-leucine;N-(Methoxycarbonyl)-3-methyl-L-valine;N-Methoxycarbonyl-tert-leucine;Atazanavir related coMpound A;MOC-L-tert. Leucin;L-Valine,N-(Methoxycarbonyl)-3-Methyl- CAS: 162537-11-3 MF: C8H15NO4 MW: 189.21 EINECS: 1308068-626-2 Product Categories: Amino Acid Derivatives;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents Mol File: 162537-11-3.mol   Methoxycarbonyl-L-tert-leucine Chemical Properties Melting point  1090C Boiling point  320.9±25.0 °C(Predicted) density  1.126±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  Soluble in ethyl acetate and methanol. pka 4.46±0.10(Predicted) form  powder InChIKey NWPRXAIYBULIEI-RXMQYKEDSA-N   Safety Information HS Code  2933399090 MSDS Information   Methoxycarbonyl-L-tert-leucine Usage And Synthesis Description Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate.  References Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328. Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016). # q=14328-63-3 Chemical Properties White Solid Uses The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.   Methoxycarbonyl-L-tert-leucine Preparation Products And Raw materials Raw materials N-Boc-L-tert-Leucine-->Methyl chloroformate-->L-tert-Leucine Preparation Products Atazanavir