China Largest Manufacturer factory sales 10-Hydroxycamptothecin CAS 19685-09-7 CAS NO.19685-09-7

                                PRODUCT DETAILS                           

10-Hydroxycamptothecin Basic information Product Name: 10-Hydroxycamptothecin Synonyms: Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy;hydroxy-camptotheci;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH) CAS: 19685-09-7 MF: C20H16N2O5 MW: 364.35 EINECS: 805-668-4 Product Categories: Inhibitors;natural product;Alkaloids;INTERMEDIATESOFIRINOTECANHCLTRIHYDRATE;Camptothecin series;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives Mol File: 19685-09-7.mol   10-Hydroxycamptothecin Chemical Properties Melting point  265-270°C Boiling point  820.7±65.0 °C(Predicted) density  1.60 storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C pka 8.93±0.40(Predicted) InChIKey HAWSQZCWOQZXHI-FQEVSTJZSA-N CAS DataBase Reference 19685-09-7(CAS DataBase Reference)   Safety Information Safety Statements  24/25 HS Code  29349990 MSDS Information   10-Hydroxycamptothecin Usage And Synthesis Description DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase. Chemical Properties Yellow Solid Uses A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy   10-Hydroxycamptothecin Preparation Products And Raw materials

                                                                       Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

10-Hydroxycamptothecin Basic information Product Name: 10-Hydroxycamptothecin Synonyms: Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy;hydroxy-camptotheci;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH) CAS: 19685-09-7 MF: C20H16N2O5 MW: 364.35 EINECS: 805-668-4 Product Categories: Inhibitors;natural product;Alkaloids;INTERMEDIATESOFIRINOTECANHCLTRIHYDRATE;Camptothecin series;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives Mol File: 19685-09-7.mol   10-Hydroxycamptothecin Chemical Properties Melting point  265-270°C Boiling point  820.7±65.0 °C(Predicted) density  1.60 storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C pka 8.93±0.40(Predicted) InChIKey HAWSQZCWOQZXHI-FQEVSTJZSA-N CAS DataBase Reference 19685-09-7(CAS DataBase Reference)   Safety Information Safety Statements  24/25 HS Code  29349990 MSDS Information   10-Hydroxycamptothecin Usage And Synthesis Description DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase. Chemical Properties Yellow Solid Uses A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy   10-Hydroxycamptothecin Preparation Products And Raw materials