China Largest Manufacturer factory Supply Betamethasone 17-valerate/BETAMETHASONE VALERATE CAS 2152-44-5 CAS NO.2152-44-5

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Betamethasone 17-valerate Basic information Product Name: Betamethasone 17-valerate Synonyms: pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopenty;9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate;9ALPHA-FLUORO-16BETA-METHYLPREDNISOLONE 17-VALERATE;9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17-VALERATE;1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE;1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate;9α-Fluoro-16β-methylprednisolone 17-valerate, Betnovate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate;BetaMethasone valerate (Betnovate) CAS: 2152-44-5 MF: C27H37FO6 MW: 476.58 EINECS: 218-439-3 Product Categories: API;BETA-VAL Mol File: 2152-44-5.mol   Betamethasone 17-valerate Chemical Properties Melting point  183-184° alpha  D +77° (dioxane) Boiling point  598.9±50.0 °C(Predicted) density  1.1174 (estimate) storage temp.  2-8°C solubility  Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent). form  neat pka 12.90±0.70(Predicted) color  White Merck  13,1183 BRN  4240001 InChIKey SNHRLVCMMWUAJD-SUYDQAKGSA-N CAS DataBase Reference 2152-44-5(CAS DataBase Reference) EPA Substance Registry System .beta.-Methasone 17-valerate (2152-44-5)   Safety Information Hazard Codes  Xn Risk Statements  48 Safety Statements  22-24/25 RTECS  TU3835000 HS Code  2937229000 MSDS Information Provider Language 1,4-Pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate English SigmaAldrich English   Betamethasone 17-valerate Usage And Synthesis Chemical Properties White Solid Originator Valisone,Schering,US,1967 Uses Betamethasone 17-Valerate is a corticosteroid with anti-inflammatory properties. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man. Uses Antiepileptic non-selective phosphodiesterase inhibitor Uses Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory and immunosuppressive activity. Uses A potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties Definition ChEBI: A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester. Indications Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid. Manufacturing Process The valerate is made from betamethasone as a starting material as follows: A suspension of 9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene- 3,20-dione(betamethasone) (2 grams) in sodium dried benzene (500 ml) was distilled vigorously for a few minutes, toluene-p-sulfonic acid monohydrate (30 mg) and methyl orthovalerate (5 ml) were added and distillation was continued for 10 minutes. The mixture was then boiled under reflux for 1.5 hours after which time unreacted betamethasone alcohol (400 mg) was removed by filtration. The benzene solution was treated with solid sodium .bicarbonate and a few drops of pyridine, filtered and evaporated to dryness at about 50°C. The residue, in ether, was filtered through grade III basic alumina (20grams) to remove traces of unreacted betamethasone alcohol, the ether removed in vacuo and the residue of crude betamethasone 17,21- methyl orthovalerate was treated with acetic acid (20ml) and a few drops of water and left overnight at room temperature. The acetic acid solution was poured into water (100 ml) and extracted with chloroform. The chloroform extracts were washed in turn with water, saturated sodium bicarbonate solution and water, dried and evaporated in vacuo. The residual gum was triturated with ether and a white crystalline solid (1.16 grams) isolated by filtration. Recrystallization from ether (containing a small amount of acetone)-petroleum ether gave 9α-fluoro-11β,21-dihydroxy-16β- methyl-17α-valeryloxypregna-1,4-diene-3,20-dione (871 mg) as fine needles. Brand name Betatrex (Savage); Luxiq (Connetics); Valisone (Schering). Therapeutic Function Corticosteroid Biochem/physiol Actions Betamethasone 17-valerate is a synthetic glucocorticoid. It exhibitstherapeutic effects against various allergic and inflammatory skin diseases. Betamethasone 17-valerate also possesses anti-inflammatory properties.   Betamethasone 17-valerate Preparation Products And Raw materials Raw materials Betamethasone

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Betamethasone 17-valerate Basic information Product Name: Betamethasone 17-valerate Synonyms: pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopenty;9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate;9ALPHA-FLUORO-16BETA-METHYLPREDNISOLONE 17-VALERATE;9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17-VALERATE;1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE;1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate;9α-Fluoro-16β-methylprednisolone 17-valerate, Betnovate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate;BetaMethasone valerate (Betnovate) CAS: 2152-44-5 MF: C27H37FO6 MW: 476.58 EINECS: 218-439-3 Product Categories: API;BETA-VAL Mol File: 2152-44-5.mol   Betamethasone 17-valerate Chemical Properties Melting point  183-184° alpha  D +77° (dioxane) Boiling point  598.9±50.0 °C(Predicted) density  1.1174 (estimate) storage temp.  2-8°C solubility  Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent). form  neat pka 12.90±0.70(Predicted) color  White Merck  13,1183 BRN  4240001 InChIKey SNHRLVCMMWUAJD-SUYDQAKGSA-N CAS DataBase Reference 2152-44-5(CAS DataBase Reference) EPA Substance Registry System .beta.-Methasone 17-valerate (2152-44-5)   Safety Information Hazard Codes  Xn Risk Statements  48 Safety Statements  22-24/25 RTECS  TU3835000 HS Code  2937229000 MSDS Information Provider Language 1,4-Pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate English SigmaAldrich English   Betamethasone 17-valerate Usage And Synthesis Chemical Properties White Solid Originator Valisone,Schering,US,1967 Uses Betamethasone 17-Valerate is a corticosteroid with anti-inflammatory properties. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man. Uses Antiepileptic non-selective phosphodiesterase inhibitor Uses Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory and immunosuppressive activity. Uses A potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties Definition ChEBI: A steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester. Indications Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid. Manufacturing Process The valerate is made from betamethasone as a starting material as follows: A suspension of 9α-fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene- 3,20-dione(betamethasone) (2 grams) in sodium dried benzene (500 ml) was distilled vigorously for a few minutes, toluene-p-sulfonic acid monohydrate (30 mg) and methyl orthovalerate (5 ml) were added and distillation was continued for 10 minutes. The mixture was then boiled under reflux for 1.5 hours after which time unreacted betamethasone alcohol (400 mg) was removed by filtration. The benzene solution was treated with solid sodium .bicarbonate and a few drops of pyridine, filtered and evaporated to dryness at about 50°C. The residue, in ether, was filtered through grade III basic alumina (20grams) to remove traces of unreacted betamethasone alcohol, the ether removed in vacuo and the residue of crude betamethasone 17,21- methyl orthovalerate was treated with acetic acid (20ml) and a few drops of water and left overnight at room temperature. The acetic acid solution was poured into water (100 ml) and extracted with chloroform. The chloroform extracts were washed in turn with water, saturated sodium bicarbonate solution and water, dried and evaporated in vacuo. The residual gum was triturated with ether and a white crystalline solid (1.16 grams) isolated by filtration. Recrystallization from ether (containing a small amount of acetone)-petroleum ether gave 9α-fluoro-11β,21-dihydroxy-16β- methyl-17α-valeryloxypregna-1,4-diene-3,20-dione (871 mg) as fine needles. Brand name Betatrex (Savage); Luxiq (Connetics); Valisone (Schering). Therapeutic Function Corticosteroid Biochem/physiol Actions Betamethasone 17-valerate is a synthetic glucocorticoid. It exhibitstherapeutic effects against various allergic and inflammatory skin diseases. Betamethasone 17-valerate also possesses anti-inflammatory properties.   Betamethasone 17-valerate Preparation Products And Raw materials Raw materials Betamethasone