China Largest Manufacturer factory Supply Itaconic Anhydride CAS 2170-03-8 CAS NO.2170-03-8

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Itaconic anhydride Basic information Product Name: Itaconic anhydride Synonyms: 2-Methylenebutanedioic anhydride;Methylenesuccinic acid anhydride;3,4-Dihydro-3-methylene-2,5-furandione Methylenesuccinic Anhydride;Itaconic anhydride(2-Methylenesuccinic anhydride);Itaconic anhydride 95%;Itaconic anhydride,98%;ITACONIC ANHYDIDE;ITACONIC ANHYDRIDE CAS: 2170-03-8 MF: C5H4O3 MW: 112.08 EINECS: 218-518-2 Product Categories:   Mol File: 2170-03-8.mol   Itaconic anhydride Chemical Properties Melting point  66-68 °C (lit.) Boiling point  114-115 °C/12 mmHg (lit.) density  1.2600 refractive index  1.5130 (estimate) Fp  114-115°C/12mm storage temp.  Store below +30°C. form  Crystalline Powder color  White to cream Water Solubility  Hydrolyzes in water. Sensitive  Moisture Sensitive BRN  2212 CAS DataBase Reference 2170-03-8(CAS DataBase Reference) NIST Chemistry Reference 2,5-Furandione, dihydro-3-methylene-(2170-03-8) EPA Substance Registry System 2,5-Furandione, dihydro-3-methylene- (2170-03-8)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  26-36-24/25 WGK Germany  3 F  3-10-21 TSCA  Yes HS Code  2917 19 80 MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   Itaconic anhydride Usage And Synthesis Chemical Properties WHITE TO CREAM CRYSTALLINE POWDER Uses Itaconic anhydride is used in immobilization of β-glucosidase. It undergoes estrification to obtain suitable monomers for emulsion polymerization itaconates. Preparation To a flask equipped with a 12 mm diameter ground glass adaptor tube bent for downward distillation and joined to a 100 cm condenser is added 200 gm (0.95 mole) of citric acid monohydrate. An ice-cooled flask and a cold trap are connected to the condenser. The flask containing the citric acid is heated rapidly with a wide flame of the Meker burner so that in 12-15 min the distillation at 175-190°C is complete. The distillation is stopped earlier if the vapors in the reaction flask become yellow. Superheating of the citric acid will cause rearrangement to citraconic anhydride. The water is quickly separated from the distillate and the itaconic anhydride layer dried to afford 40-50 gm (37-47%), m.p. 67-68°C. Long time contact of the water with the anhydride causes it to hydrolyze to itaconic acid, m.p. 162-165°C. Synthesis Reference(s) Tetrahedron Letters, 25, p. 6027, 1984 DOI: 10.1016/S0040-4039(01)81751-2 General Description Itaconic anhydride (ITA) is a biobased material that is obtained from renewable resources. It is produced from the pyrolysis of citric acid or by fermenting carbohydrates which forms itanoic acid. Itanoic acid can be dehydrated to form an anhydride. It is relatively more reactive that maleic anhydride and can be used as an alternating monomer that facilitates the introduction of polar functionalities in polymers. Purification Methods Crystallise the anhydride from CHCl3/pet ether. It can be distilled under reduced pressure. Distillation at atmospheric pressure, or prolonged distillation causes rearrangement to citraconic anhydride (2-methylmaleic anhydride). If the material (as seen in the IR spectrum) contains much free acid, then heat with acetyl chloride or SOCl2, evaporate and distil at as high a vacuum as possible. The crude anhydride deposits crystals of itaconic acid on standing probably due to hydrolysis by H2O — store it in sealed ampoules under dry N2. [Skinner et al. Org Synth Coll Vol II 368 1943, IR: Nagai Bull Chem Soc Jpn 37 369 1964, Kelly & Segura J Am Chem Soc 56 2497 1934, Beilstein 17/11 V 66.]   Itaconic anhydride Preparation Products And Raw materials Raw materials Citric acid-->Itaconic acid-->CIS-ACONITIC ANHYDRIDE-->TRANS-ACONITIC ACID ANHYDRIDE-->Aconitic Acid Preparation Products Citraconic anhydride-->ITACONIC ACID MONO-N-BUTYL ESTER-->Itaconic acid monomethyl ester-->DIBUTYL ITACONATE-->ITACONYL CHLORIDE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Itaconic anhydride Basic information Product Name: Itaconic anhydride Synonyms: 2-Methylenebutanedioic anhydride;Methylenesuccinic acid anhydride;3,4-Dihydro-3-methylene-2,5-furandione Methylenesuccinic Anhydride;Itaconic anhydride(2-Methylenesuccinic anhydride);Itaconic anhydride 95%;Itaconic anhydride,98%;ITACONIC ANHYDIDE;ITACONIC ANHYDRIDE CAS: 2170-03-8 MF: C5H4O3 MW: 112.08 EINECS: 218-518-2 Product Categories:   Mol File: 2170-03-8.mol   Itaconic anhydride Chemical Properties Melting point  66-68 °C (lit.) Boiling point  114-115 °C/12 mmHg (lit.) density  1.2600 refractive index  1.5130 (estimate) Fp  114-115°C/12mm storage temp.  Store below +30°C. form  Crystalline Powder color  White to cream Water Solubility  Hydrolyzes in water. Sensitive  Moisture Sensitive BRN  2212 CAS DataBase Reference 2170-03-8(CAS DataBase Reference) NIST Chemistry Reference 2,5-Furandione, dihydro-3-methylene-(2170-03-8) EPA Substance Registry System 2,5-Furandione, dihydro-3-methylene- (2170-03-8)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  26-36-24/25 WGK Germany  3 F  3-10-21 TSCA  Yes HS Code  2917 19 80 MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   Itaconic anhydride Usage And Synthesis Chemical Properties WHITE TO CREAM CRYSTALLINE POWDER Uses Itaconic anhydride is used in immobilization of β-glucosidase. It undergoes estrification to obtain suitable monomers for emulsion polymerization itaconates. Preparation To a flask equipped with a 12 mm diameter ground glass adaptor tube bent for downward distillation and joined to a 100 cm condenser is added 200 gm (0.95 mole) of citric acid monohydrate. An ice-cooled flask and a cold trap are connected to the condenser. The flask containing the citric acid is heated rapidly with a wide flame of the Meker burner so that in 12-15 min the distillation at 175-190°C is complete. The distillation is stopped earlier if the vapors in the reaction flask become yellow. Superheating of the citric acid will cause rearrangement to citraconic anhydride. The water is quickly separated from the distillate and the itaconic anhydride layer dried to afford 40-50 gm (37-47%), m.p. 67-68°C. Long time contact of the water with the anhydride causes it to hydrolyze to itaconic acid, m.p. 162-165°C. Synthesis Reference(s) Tetrahedron Letters, 25, p. 6027, 1984 DOI: 10.1016/S0040-4039(01)81751-2 General Description Itaconic anhydride (ITA) is a biobased material that is obtained from renewable resources. It is produced from the pyrolysis of citric acid or by fermenting carbohydrates which forms itanoic acid. Itanoic acid can be dehydrated to form an anhydride. It is relatively more reactive that maleic anhydride and can be used as an alternating monomer that facilitates the introduction of polar functionalities in polymers. Purification Methods Crystallise the anhydride from CHCl3/pet ether. It can be distilled under reduced pressure. Distillation at atmospheric pressure, or prolonged distillation causes rearrangement to citraconic anhydride (2-methylmaleic anhydride). If the material (as seen in the IR spectrum) contains much free acid, then heat with acetyl chloride or SOCl2, evaporate and distil at as high a vacuum as possible. The crude anhydride deposits crystals of itaconic acid on standing probably due to hydrolysis by H2O — store it in sealed ampoules under dry N2. [Skinner et al. Org Synth Coll Vol II 368 1943, IR: Nagai Bull Chem Soc Jpn 37 369 1964, Kelly & Segura J Am Chem Soc 56 2497 1934, Beilstein 17/11 V 66.]   Itaconic anhydride Preparation Products And Raw materials Raw materials Citric acid-->Itaconic acid-->CIS-ACONITIC ANHYDRIDE-->TRANS-ACONITIC ACID ANHYDRIDE-->Aconitic Acid Preparation Products Citraconic anhydride-->ITACONIC ACID MONO-N-BUTYL ESTER-->Itaconic acid monomethyl ester-->DIBUTYL ITACONATE-->ITACONYL CHLORIDE