China Biggest Factory manufacturer supply L-Menthol CAS NO.2216-51-5

                                PRODUCT DETAILS                           

L-Menthol Basic information Product Name: L-Menthol Synonyms: (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol;(1r,3r,4s)-(-)-mentho;(1R,3R,4S)-(-)-MENTHOL;(R)-(-)-Menthol;Emtricitabine Impurity 31;Natural Menthol Crystal;L-Meng alcohol Natural menthol Menthol (L);DL-Menthol menthol crystal extract CAS: 2216-51-5 MF: C10H20O MW: 156.27 EINECS: 218-690-9 Product Categories: Inhibitors;Organics;chiral;Biochemistry;Terpenes;API;Terpenes (Others);for Resolution of Acids;Monocyclic Monoterpenes;Optical Resolution;Synthetic Organic Chemistry Mol File: 2216-51-5.mol   L-Menthol Chemical Properties Melting point  41-45 °C (lit.) alpha  -51 º (589nm, c=10, EtOH) Boiling point  212 °C (lit.) density  0.89 g/mL at 25 °C (lit.) vapor pressure  0.8 mm Hg ( 20 °C) FEMA  2665 | MENTHOL RACEMIC refractive index  1.46 Fp  200 °F storage temp.  Store below +30°C. solubility  490mg/l form  Crystals or Crystalline Needles pka 15.30±0.60(Predicted) color  Colorless to white Specific Gravity 0.89 optical activity [α]22/D 49°, c = 10 in 95% ethanol Water Solubility  insoluble Merck  14,5837 BRN  1902293 Stability: Stable. InChIKey NOOLISFMXDJSKH-KXUCPTDWSA-N CAS DataBase Reference 2216-51-5(CAS DataBase Reference) NIST Chemistry Reference Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1«alpha»,2«beta»,5«alpha»)]-(2216-51-5) EPA Substance Registry System Levomenthol (2216-51-5)   Safety Information Hazard Codes  Xi Risk Statements  37/38-41-36/37/38 Safety Statements  26-39-37/39-36 WGK Germany  2 RTECS  OT0700000 TSCA  Yes HS Code  29061100 Hazardous Substances Data 2216-51-5(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg MSDS Information Provider Language (1R,2S,5R)-(-)-Menthol English SigmaAldrich English ACROS English ALFA English   L-Menthol Usage And Synthesis Chemical Properties white to light yellow crystal powde Uses analgesic (topical), antipruritic agent Uses (1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L-Menthol is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics. Uses L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics. Definition ChEBI: A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. General Description Produced and qualified by HWI pharma services GmbH. Exact content by quantitative NMR can be found on the certificate. Biochem/physiol Actions Taste at 25 ppm Safety Profile Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An eye irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Purification Methods Crystallise menthol from CHCl3,pet ether or EtOH/water. [Barrow & Atkinson J Chem Soc 638 1939, Beilstein 6 III 133, 6 IV 150.]   L-Menthol Preparation Products And Raw materials Raw materials m-Cresol-->Petroleum crude oil-->Citronellal-->Thymol-->Cornmint oil-->PEPPERMINT-->DL-Menthol-->ISOPULEGOL, TECH.-->L-MENTHONE-->NEOMENTHOL, (-)-(SG)-->(+)-NEOMENTHOL Preparation Products (R,R)-DIPAMP-->(-)-MENTHOXYACETIC ACID-->Benzenesulfinic acid, 4-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester-->p-Toluenethiosulfonic acid S-p-tolyl ester-->Menthyl isovalerate-->(-)-MENTHYL CHLOROFORMATE

                                Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

L-Menthol Basic information Product Name: L-Menthol Synonyms: (1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol;(1r,3r,4s)-(-)-mentho;(1R,3R,4S)-(-)-MENTHOL;(R)-(-)-Menthol;Emtricitabine Impurity 31;Natural Menthol Crystal;L-Meng alcohol Natural menthol Menthol (L);DL-Menthol menthol crystal extract CAS: 2216-51-5 MF: C10H20O MW: 156.27 EINECS: 218-690-9 Product Categories: Inhibitors;Organics;chiral;Biochemistry;Terpenes;API;Terpenes (Others);for Resolution of Acids;Monocyclic Monoterpenes;Optical Resolution;Synthetic Organic Chemistry Mol File: 2216-51-5.mol   L-Menthol Chemical Properties Melting point  41-45 °C (lit.) alpha  -51 º (589nm, c=10, EtOH) Boiling point  212 °C (lit.) density  0.89 g/mL at 25 °C (lit.) vapor pressure  0.8 mm Hg ( 20 °C) FEMA  2665 | MENTHOL RACEMIC refractive index  1.46 Fp  200 °F storage temp.  Store below +30°C. solubility  490mg/l form  Crystals or Crystalline Needles pka 15.30±0.60(Predicted) color  Colorless to white Specific Gravity 0.89 optical activity [α]22/D 49°, c = 10 in 95% ethanol Water Solubility  insoluble Merck  14,5837 BRN  1902293 Stability: Stable. InChIKey NOOLISFMXDJSKH-KXUCPTDWSA-N CAS DataBase Reference 2216-51-5(CAS DataBase Reference) NIST Chemistry Reference Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1«alpha»,2«beta»,5«alpha»)]-(2216-51-5) EPA Substance Registry System Levomenthol (2216-51-5)   Safety Information Hazard Codes  Xi Risk Statements  37/38-41-36/37/38 Safety Statements  26-39-37/39-36 WGK Germany  2 RTECS  OT0700000 TSCA  Yes HS Code  29061100 Hazardous Substances Data 2216-51-5(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg MSDS Information Provider Language (1R,2S,5R)-(-)-Menthol English SigmaAldrich English ACROS English ALFA English   L-Menthol Usage And Synthesis Chemical Properties white to light yellow crystal powde Uses analgesic (topical), antipruritic agent Uses (1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L-Menthol is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics. Uses L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics. Definition ChEBI: A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. General Description Produced and qualified by HWI pharma services GmbH. Exact content by quantitative NMR can be found on the certificate. Biochem/physiol Actions Taste at 25 ppm Safety Profile Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An eye irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Purification Methods Crystallise menthol from CHCl3,pet ether or EtOH/water. [Barrow & Atkinson J Chem Soc 638 1939, Beilstein 6 III 133, 6 IV 150.]   L-Menthol Preparation Products And Raw materials Raw materials m-Cresol-->Petroleum crude oil-->Citronellal-->Thymol-->Cornmint oil-->PEPPERMINT-->DL-Menthol-->ISOPULEGOL, TECH.-->L-MENTHONE-->NEOMENTHOL, (-)-(SG)-->(+)-NEOMENTHOL Preparation Products (R,R)-DIPAMP-->(-)-MENTHOXYACETIC ACID-->Benzenesulfinic acid, 4-methyl-, 5-methyl-2-(1-methylethyl)cyclohexyl ester-->p-Toluenethiosulfonic acid S-p-tolyl ester-->Menthyl isovalerate-->(-)-MENTHYL CHLOROFORMATE