China Biggest Manufacturer factory sales Benfotiamine CAS 22457-89-2 CAS NO.22457-89-2

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Benfotiamine Basic information Product Name: Benfotiamine Synonyms: benzoylthiamineo-monophosphate;berdi;betivina;benphothiamine;BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester CAS: 22457-89-2 MF: C19H23N4O6PS MW: 466.45 EINECS: 245-013-4 Product Categories: API;BIOTAMIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical intermediate;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Sulfur & Selenium Compounds Mol File: 22457-89-2.mol   Benfotiamine Chemical Properties Melting point  165 C Boiling point  745.1±70.0 °C(Predicted) density  1.444±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  Aqueous Acid (Slightly), DMSO (Heated, Sonicated) form  Solid pka 1.84±0.10(Predicted) color  White to Off-White Merck  14,1041 InChIKey BTNNPSLJPBRMLZ-GHRIWEEISA-N CAS DataBase Reference 22457-89-2(CAS DataBase Reference)   Safety Information Hazard Codes  Xn Risk Statements  20/21/22-36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  DH6910000 MSDS Information Provider Language SigmaAldrich English   Benfotiamine Usage And Synthesis Chemical Properties crystals Originator Biotamin,Sankyo Uses S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat. Uses Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185). Definition ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation. Manufacturing Process 28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated. The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition). Therapeutic Function Analgesic General Description S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine. Biochem/physiol Actions S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.   Benfotiamine Preparation Products And Raw materials Raw materials Benzoyl chloride-->Thiamine hydrochloride-->Phosphoric acid Tag:Benfotiamine(22457-89-2) Related Product Information

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Benfotiamine Basic information Product Name: Benfotiamine Synonyms: benzoylthiamineo-monophosphate;berdi;betivina;benphothiamine;BENFOTAMINE (S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloic ester phenylcarbathionoic acid;Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl];Thiobenzoic acid S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl] ester CAS: 22457-89-2 MF: C19H23N4O6PS MW: 466.45 EINECS: 245-013-4 Product Categories: API;BIOTAMIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceutical intermediate;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Sulfur & Selenium Compounds Mol File: 22457-89-2.mol   Benfotiamine Chemical Properties Melting point  165 C Boiling point  745.1±70.0 °C(Predicted) density  1.444±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  Aqueous Acid (Slightly), DMSO (Heated, Sonicated) form  Solid pka 1.84±0.10(Predicted) color  White to Off-White Merck  14,1041 InChIKey BTNNPSLJPBRMLZ-GHRIWEEISA-N CAS DataBase Reference 22457-89-2(CAS DataBase Reference)   Safety Information Hazard Codes  Xn Risk Statements  20/21/22-36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  DH6910000 MSDS Information Provider Language SigmaAldrich English   Benfotiamine Usage And Synthesis Chemical Properties crystals Originator Biotamin,Sankyo Uses S-Benzoylthiamine O-monophosphate has been used to determine its effect on ischemia and reperfusion in skeletal muscles of rat. Uses Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185). Definition ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation. Manufacturing Process 28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated. The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition). Therapeutic Function Analgesic General Description S-Benzoylthiamine O-monophosphate (Benfotiamine) is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine contains a thiazole ring. Benfotiamine has a greater bioavailability than thiamine. Biochem/physiol Actions S-Benzoylthiamine O-monophosphate (Benfotiamine) is a therapeutic agent. It helps in the prevention of diabetic complications such as, retinopathy, neuropathy and nephropathy. Benfotiamine inhibits the synthesis of glycation end products (AGEs) in diabetes. Benfotiamine is considered as a nutraceutical product for the prevention of diabetic neuropathy.   Benfotiamine Preparation Products And Raw materials Raw materials Benzoyl chloride-->Thiamine hydrochloride-->Phosphoric acid Tag:Benfotiamine(22457-89-2) Related Product Information