China Largest Manufacturer factory Supply Silybin / Silybine / Silibinin CAS 22888-70-6 CAS NO.22888-70-6

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Silibinin Basic information Product Name: Silibinin Synonyms: SILYBIN;SILYBIN A;SILYBIN (A AND B);SILYMARIN;SILYMARIN I;SILYBININ;SILYBIN (MIX);SILIBININ CAS: 22888-70-6 MF: C25H22O10 MW: 482.44 EINECS: 245-302-5 Product Categories: Aromatics;Chiral Reagents;Angiogenesis InhibitorsCancer Research;Anti-proliferative AgentsNutrition Research;Angiogenesis;Biochemicals Found in Plants;Flavanones;Natural Plant Extract;Bioflavonoids;Cancer Research;Chemopreventive Agents;chemical reagent;Plant extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;Plant extracts;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 22888-70-6.mol   Silibinin Chemical Properties Melting point  164-174°C alpha  D20 +11° (c = 0.25 in acetone + alcohol) Boiling point  793.0±60.0 °C(Predicted) density  1.527±0.06 g/cm3(Predicted) storage temp.  -20°C solubility  Acetone (Sparingly), DMSO, Methano (Sparingly) form  Solid pka pKa 6.42±0.04 (Uncertain) color  Pale Yellow Water Solubility  54mg/L(24.99 ºC) Merck  13,8607 Stability: Stable. Incompatible with strong oxidizing agents, strong bases. CAS DataBase Reference 22888-70-6(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-37/39-24/25-22-36 RIDADR  3172 WGK Germany  3 RTECS  DJ2981770 HS Code  29329990 Toxicity LD50 intravenous in mouse: 1056mg/kg MSDS Information   Silibinin Usage And Synthesis Chemical Properties solid Originator Legalon,Madaus,W. Germany,1969 Uses Silibinin has been used: to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR) to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay to examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing to study its inhibitory effect on Escherichia coli ATP synthase Uses Labelled Silybin (S465850). Hepatoprotectant. Definition ChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. Manufacturing Process Silymarin comprising polyhydroxyphenyl chromanones is recovered from the dried fruit of Silybum marianum Gaertn. by separating the fatty oils therefrom, extracting the remaining solid residue with ethyl acetate, evaporating the ethyl acetate and dissolving the dry residue in a solvent mixture comprising methanol, water and petroleum ether to form a two-phase system wherein the chromanones are contained in the lower phase, recovering the polyhydroxyphenyl chromanones from the lower phase after subjecting same to multiple counter-current contact with petroleum ether. Therapeutic Function Hepatoprotectant General Description Silibinin, a principal component of silymarin, is a flavonolignan and an orally active flavonoid. It is isolated from the seeds of milk thistle (Sylibum marianum L). Biochem/physiol Actions Silibinin functions as a hepatoprotectant in patients with acute and chronic liver injury. This flavonoid fights against various cancer cells including, prostate, skin, breast, colon, lung, bladder and hepatocellular carcinoma (HCC). Silibinin exhibits its efficacy as an anti-cancer agent by blocking the secretion of proangiogenic factors from tumor cells, and by hindering growth and inducing apoptotic death of endothelial cells. In addition, it also interrupts capillary tube formation on Matrigel. Silibinin might be a good candidate for chemoprevention of prostate cancer (PC). It might be used as a potential therapeutic regimen for the treatment of endometriosis in vitro and in vivo.   Silibinin Preparation Products And Raw materials Raw materials Ethyl acetate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Silibinin Basic information Product Name: Silibinin Synonyms: SILYBIN;SILYBIN A;SILYBIN (A AND B);SILYMARIN;SILYMARIN I;SILYBININ;SILYBIN (MIX);SILIBININ CAS: 22888-70-6 MF: C25H22O10 MW: 482.44 EINECS: 245-302-5 Product Categories: Aromatics;Chiral Reagents;Angiogenesis InhibitorsCancer Research;Anti-proliferative AgentsNutrition Research;Angiogenesis;Biochemicals Found in Plants;Flavanones;Natural Plant Extract;Bioflavonoids;Cancer Research;Chemopreventive Agents;chemical reagent;Plant extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;Plant extracts;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 22888-70-6.mol   Silibinin Chemical Properties Melting point  164-174°C alpha  D20 +11° (c = 0.25 in acetone + alcohol) Boiling point  793.0±60.0 °C(Predicted) density  1.527±0.06 g/cm3(Predicted) storage temp.  -20°C solubility  Acetone (Sparingly), DMSO, Methano (Sparingly) form  Solid pka pKa 6.42±0.04 (Uncertain) color  Pale Yellow Water Solubility  54mg/L(24.99 ºC) Merck  13,8607 Stability: Stable. Incompatible with strong oxidizing agents, strong bases. CAS DataBase Reference 22888-70-6(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-37/39-24/25-22-36 RIDADR  3172 WGK Germany  3 RTECS  DJ2981770 HS Code  29329990 Toxicity LD50 intravenous in mouse: 1056mg/kg MSDS Information   Silibinin Usage And Synthesis Chemical Properties solid Originator Legalon,Madaus,W. Germany,1969 Uses Silibinin has been used: to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR) to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay to examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing to study its inhibitory effect on Escherichia coli ATP synthase Uses Labelled Silybin (S465850). Hepatoprotectant. Definition ChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. Manufacturing Process Silymarin comprising polyhydroxyphenyl chromanones is recovered from the dried fruit of Silybum marianum Gaertn. by separating the fatty oils therefrom, extracting the remaining solid residue with ethyl acetate, evaporating the ethyl acetate and dissolving the dry residue in a solvent mixture comprising methanol, water and petroleum ether to form a two-phase system wherein the chromanones are contained in the lower phase, recovering the polyhydroxyphenyl chromanones from the lower phase after subjecting same to multiple counter-current contact with petroleum ether. Therapeutic Function Hepatoprotectant General Description Silibinin, a principal component of silymarin, is a flavonolignan and an orally active flavonoid. It is isolated from the seeds of milk thistle (Sylibum marianum L). Biochem/physiol Actions Silibinin functions as a hepatoprotectant in patients with acute and chronic liver injury. This flavonoid fights against various cancer cells including, prostate, skin, breast, colon, lung, bladder and hepatocellular carcinoma (HCC). Silibinin exhibits its efficacy as an anti-cancer agent by blocking the secretion of proangiogenic factors from tumor cells, and by hindering growth and inducing apoptotic death of endothelial cells. In addition, it also interrupts capillary tube formation on Matrigel. Silibinin might be a good candidate for chemoprevention of prostate cancer (PC). It might be used as a potential therapeutic regimen for the treatment of endometriosis in vitro and in vivo.   Silibinin Preparation Products And Raw materials Raw materials Ethyl acetate