China Largest Manufacturer factory Supply Glycerol Monoleate CAS 25496-72-4 CAS NO.25496-72-4

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MONOOLEIN Basic information Product Name: MONOOLEIN Synonyms: DL-ALPHA-MONOOLEIN;DELTA 9 CIS MONOOLEIN;GLYCERYL CIS-9-OCTADECENOATE;GLYCEROL MONOOLEATE;GLYCEROL ALPHA-MONOOLEATE;GLYCEROL-1-MONOOLEATE;oleic acid, monoester with glycerol;9-Octadecenoic acid (9Z)-, monoester with 1,2,3-propanetriol CAS: 25496-72-4 MF: C21H40O4 MW: 356.54 EINECS: 247-038-6 Product Categories: Cosmetic Ingredients & Chemicals;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols Mol File: 25496-72-4.mol   MONOOLEIN Chemical Properties Melting point  35-37 °C Boiling point  449.35°C (rough estimate) density  0.96 g/cm3 (25 ºC) refractive index  1.4626 (589.3 nm 40℃) FEMA  2526 | GLYCERYL MONOOLEATE storage temp.  −20°C solubility  chloroform: 50 mg/mL, clear, colorless form  neat Water Solubility  <3.57mg/L(30 ºC) CAS DataBase Reference 25496-72-4(CAS DataBase Reference) EPA Substance Registry System Glyceryl monooleate (25496-72-4)   Safety Information WGK Germany  1 F  3 HS Code  3822000002 Hazardous Substances Data 25496-72-4(Hazardous Substances Data) MSDS Information Provider Language SigmaAldrich English   MONOOLEIN Usage And Synthesis Description § 184.1323(a) Glyceryl monooleate is prepared by esterification of commercial oleic acid that is derived either from edible sources or from tall oil fatty acids meeting the requirements of §172.862. It contains glyceryl monooleate (C21H40O4 and glyceryl esters of fatty acids present in commercial oleic acid. Chemical Properties Glyceryl monooleate has a faint fatty odor It is a polar lipid that swells in water to give several phases with different rheological properties Glyceryl monooleate is a mixture of the glycerides of oleic acid and other fatty acids, consisting mainly of monooleate. Chemical Properties Colourless Solid Chemical Properties The PhEur 6.3 describes glyceryl monooleate as being a mixture of monoacylglycerols, mainly monooleoylglycerol, together with variable quantities of di- and triacylglycerols. They are defined by the nominal content of monoacylglycerols and obtained by partial glycerolysis of vegetable oils mainly containing triacylglycerols of oleic acid or by esterification of glycerol by oleic acid, this fatty acid being of vegetable or animal origin. A suitable antioxidant may be added. Glyceryl monooleates occur as amber oily liquids, which may be partially solidified at room temperature and have a characteristic odor. Uses 93% 1-Oleoyl, 7% 2-oleoyl Uses Glycerol Monoleate is used to synthesize water soluble drugs in need of sustained-release for drug delivery. Definition An antifog agent and dispersant. Production Methods Glyceryl monooleate is prepared by the esterification of glycerol with fatty acids, chiefly oleic acid. As the fatty acids are not pure substances, but rather a mixture of fatty acids, the product obtained from the esterification will contain a mixture of esters, including stearic and palmitic. Di- and triesters may also be present. The composition and, therefore, the physical properties of glyceryl monooleate may thus vary considerably from manufacturer to manufacturer; e.g. the melting point may vary from 10–35°C. Pharmaceutical Applications Glyceryl monooleate is a polar lipid that swells in water to give several phases with different rheological properties. It is available in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the self-emulsifying grade containing about 5% of an anionic surfactant. The nonemulsifying grade is used in topical formulations as an emollient and as an emulsifying agent for water-in-oil emulsions. It is also a stabilizer for oil-in-water emulsions. The self-emulsifying grade is used as a primary emulsifier for oil-in-water systems. Glyceryl monooleate gels in excess water, forming a highly ordered cubic phase that can be used to sustain the release of various water-soluble drugs.It is also the basis of mucoadhesive drug delivery systems. Glyceryl monooleate is reported to enhance transdermal and buccal penetration. Safety Profile When heated to decomposition it emits acrid smoke and irritating fumes. Safety Glyceryl monooleate is used in oral and topical pharmaceutical formulations and is generally regarded as a relatively nonirritant and nontoxic excipient. storage Glyceryl monooleate should be stored in an airtight container, protected from light in a cool, dry place. Incompatibilities Glyceryl monooleate is incompatible with strong oxidizing agents. The self-emulsifying grade is incompatible with cationic surfactants. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, oral powder, oral tablets; creams, controlled-release transdermal films). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   MONOOLEIN Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

MONOOLEIN Basic information Product Name: MONOOLEIN Synonyms: DL-ALPHA-MONOOLEIN;DELTA 9 CIS MONOOLEIN;GLYCERYL CIS-9-OCTADECENOATE;GLYCEROL MONOOLEATE;GLYCEROL ALPHA-MONOOLEATE;GLYCEROL-1-MONOOLEATE;oleic acid, monoester with glycerol;9-Octadecenoic acid (9Z)-, monoester with 1,2,3-propanetriol CAS: 25496-72-4 MF: C21H40O4 MW: 356.54 EINECS: 247-038-6 Product Categories: Cosmetic Ingredients & Chemicals;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols Mol File: 25496-72-4.mol   MONOOLEIN Chemical Properties Melting point  35-37 °C Boiling point  449.35°C (rough estimate) density  0.96 g/cm3 (25 ºC) refractive index  1.4626 (589.3 nm 40℃) FEMA  2526 | GLYCERYL MONOOLEATE storage temp.  −20°C solubility  chloroform: 50 mg/mL, clear, colorless form  neat Water Solubility  <3.57mg/L(30 ºC) CAS DataBase Reference 25496-72-4(CAS DataBase Reference) EPA Substance Registry System Glyceryl monooleate (25496-72-4)   Safety Information WGK Germany  1 F  3 HS Code  3822000002 Hazardous Substances Data 25496-72-4(Hazardous Substances Data) MSDS Information Provider Language SigmaAldrich English   MONOOLEIN Usage And Synthesis Description § 184.1323(a) Glyceryl monooleate is prepared by esterification of commercial oleic acid that is derived either from edible sources or from tall oil fatty acids meeting the requirements of §172.862. It contains glyceryl monooleate (C21H40O4 and glyceryl esters of fatty acids present in commercial oleic acid. Chemical Properties Glyceryl monooleate has a faint fatty odor It is a polar lipid that swells in water to give several phases with different rheological properties Glyceryl monooleate is a mixture of the glycerides of oleic acid and other fatty acids, consisting mainly of monooleate. Chemical Properties Colourless Solid Chemical Properties The PhEur 6.3 describes glyceryl monooleate as being a mixture of monoacylglycerols, mainly monooleoylglycerol, together with variable quantities of di- and triacylglycerols. They are defined by the nominal content of monoacylglycerols and obtained by partial glycerolysis of vegetable oils mainly containing triacylglycerols of oleic acid or by esterification of glycerol by oleic acid, this fatty acid being of vegetable or animal origin. A suitable antioxidant may be added. Glyceryl monooleates occur as amber oily liquids, which may be partially solidified at room temperature and have a characteristic odor. Uses 93% 1-Oleoyl, 7% 2-oleoyl Uses Glycerol Monoleate is used to synthesize water soluble drugs in need of sustained-release for drug delivery. Definition An antifog agent and dispersant. Production Methods Glyceryl monooleate is prepared by the esterification of glycerol with fatty acids, chiefly oleic acid. As the fatty acids are not pure substances, but rather a mixture of fatty acids, the product obtained from the esterification will contain a mixture of esters, including stearic and palmitic. Di- and triesters may also be present. The composition and, therefore, the physical properties of glyceryl monooleate may thus vary considerably from manufacturer to manufacturer; e.g. the melting point may vary from 10–35°C. Pharmaceutical Applications Glyceryl monooleate is a polar lipid that swells in water to give several phases with different rheological properties. It is available in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the self-emulsifying grade containing about 5% of an anionic surfactant. The nonemulsifying grade is used in topical formulations as an emollient and as an emulsifying agent for water-in-oil emulsions. It is also a stabilizer for oil-in-water emulsions. The self-emulsifying grade is used as a primary emulsifier for oil-in-water systems. Glyceryl monooleate gels in excess water, forming a highly ordered cubic phase that can be used to sustain the release of various water-soluble drugs.It is also the basis of mucoadhesive drug delivery systems. Glyceryl monooleate is reported to enhance transdermal and buccal penetration. Safety Profile When heated to decomposition it emits acrid smoke and irritating fumes. Safety Glyceryl monooleate is used in oral and topical pharmaceutical formulations and is generally regarded as a relatively nonirritant and nontoxic excipient. storage Glyceryl monooleate should be stored in an airtight container, protected from light in a cool, dry place. Incompatibilities Glyceryl monooleate is incompatible with strong oxidizing agents. The self-emulsifying grade is incompatible with cationic surfactants. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, oral powder, oral tablets; creams, controlled-release transdermal films). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   MONOOLEIN Preparation Products And Raw materials