China Largest Factory Manufacturer sales Scutellarin CAS 27740-01-8 CAS NO.27740-01-8

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Scutellarin Basic information Product Name: Scutellarin Synonyms: SCUTELLARIN, 98+% BY HPLC;(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl;β-D-Glucopyranosiduronicacid,5,6-dihydroxy-2-;4',5,6-Trihydroxy-7-[(β-D-glucopyranuronosyl)oxy]flavone;4',5,6-Trihydroxyflavon-7-yl β-D-glucopyranosiduronic acid;5,6-Dihydroxy-4-oxo-2-(4-hydroxyphenyl)-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid;Scutellarein 4'-methyl ether 7-glucuronide;Scutellarein 7-glucuronide CAS: 27740-01-8 MF: C21H18O12 MW: 462.36 EINECS: 1806241-263-5 Product Categories: Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors Mol File: 27740-01-8.mol   Scutellarin Chemical Properties Melting point  300～301℃ Boiling point  891.6±65.0 °C(Predicted) density  1.810±0.06 g/cm3(Predicted) storage temp.  Sealed in dry,2-8°C solubility  DMSO (Slightly), Methanol (Very Slightly, Sonicated) form  neat pka 2.72±0.70(Predicted) color  Light Yellow to Yellow BRN  71779 CAS DataBase Reference 27740-01-8(CAS DataBase Reference)   Safety Information Safety Statements  24/25 WGK Germany  3 HS Code  29389090 MSDS Information   Scutellarin Usage And Synthesis Description Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911). Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively. Uses Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells. Uses Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascula r diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells. Definition ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.   Scutellarin Preparation Products And Raw materials Raw materials 4',5,6,7-Tetrahydroxyflavone tetraacetate-->(2S,3S,4R,5R,6R)-6-[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic-->SCUTELLAREIN-->scutellarin Methylester Preparation Products cirsimaritin

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Scutellarin Basic information Product Name: Scutellarin Synonyms: SCUTELLARIN, 98+% BY HPLC;(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl;β-D-Glucopyranosiduronicacid,5,6-dihydroxy-2-;4',5,6-Trihydroxy-7-[(β-D-glucopyranuronosyl)oxy]flavone;4',5,6-Trihydroxyflavon-7-yl β-D-glucopyranosiduronic acid;5,6-Dihydroxy-4-oxo-2-(4-hydroxyphenyl)-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid;Scutellarein 4'-methyl ether 7-glucuronide;Scutellarein 7-glucuronide CAS: 27740-01-8 MF: C21H18O12 MW: 462.36 EINECS: 1806241-263-5 Product Categories: Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors Mol File: 27740-01-8.mol   Scutellarin Chemical Properties Melting point  300～301℃ Boiling point  891.6±65.0 °C(Predicted) density  1.810±0.06 g/cm3(Predicted) storage temp.  Sealed in dry,2-8°C solubility  DMSO (Slightly), Methanol (Very Slightly, Sonicated) form  neat pka 2.72±0.70(Predicted) color  Light Yellow to Yellow BRN  71779 CAS DataBase Reference 27740-01-8(CAS DataBase Reference)   Safety Information Safety Statements  24/25 WGK Germany  3 HS Code  29389090 MSDS Information   Scutellarin Usage And Synthesis Description Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ (Item No. 17911). Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively. Uses Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells. Uses Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascula r diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells. Definition ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.   Scutellarin Preparation Products And Raw materials Raw materials 4',5,6,7-Tetrahydroxyflavone tetraacetate-->(2S,3S,4R,5R,6R)-6-[[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic-->SCUTELLAREIN-->scutellarin Methylester Preparation Products cirsimaritin