China Biggest Factory manufacturer supply DMSA/meso-2,3-Dimercaptosuccinic Acid CAS NO.304-55-2

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Succimer Basic information Product Name: Succimer Synonyms: (2R,3S)-2,3-diMercaptosuccinic acid;(2R,3S)-rel-2,3-DiMercaptosuccinic acid;Butanedioic acid,2,3-diMercapto-, (2R,3S)-rel-;meso-2,3-Dimercaptosuccinic acid;API Succimer;-rel-2,3-Dimercaptosuccinic acid;(2S,3R)-2,3-dimercaptobutanedioate;(r*,s*)-2,3-dimercaptobutanedioicacid CAS: 304-55-2 MF: C4H6O4S2 MW: 182.22 EINECS: 206-155-2 Product Categories: API;Inhibitors;Organic acids;Analytical Chemistry;Ligands for Pharmaceutical Research;Radiopharmaceutical Chemistry (Chelating Reagents);Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans Mol File: 304-55-2.mol   Succimer Chemical Properties Melting point  196-198 °C (dec.)(lit.) Boiling point  285.62°C (rough estimate) density  1.439 (estimate) refractive index  1.5220 (estimate) storage temp.  -20°C solubility  DMSO (Sparingly), Methanol (Slightly, Heated) pka pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C) form  Powder color  White to off-white Water Solubility  Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear). Merck  14,8865 BRN  1725150 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. InChIKey ACTRVOBWPAIOHC-XIXRPRMCSA-N CAS DataBase Reference 304-55-2(CAS DataBase Reference) EPA Substance Registry System Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  24/25-36-26 WGK Germany  2 RTECS  WM7650000 F  10-23 TSCA  Yes HS Code  29309090 Hazardous Substances Data 304-55-2(Hazardous Substances Data) Toxicity LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi) MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   Succimer Usage And Synthesis Description Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults. Chemical Properties white or off-white powder Originator Johnson and Johnson (J&J) (U.S.A.) Uses A selective masking agent for cadmium in EDTA titration of zinc. Uses chelating agent, antihypertensive Uses meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc. Uses chelating agent, treatment of lead poisoning Uses A water-soluble chelating agent. Uses Chelating agent. Definition ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning. Brand name Chemet (Ovation). Pharmaceutical Applications Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent. DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been successfully used for the treatment of heavy-metal poisoning. Pharmaceutical Applications The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning. Veterinary Drugs and Treatments In veterinary medicine, succimer may be useful for the oral treatment of lead poisoning in small animals (including birds). Potentially, it also may be of benefit for the treatment of other toxic heavy metals such as arsenic or mercury, but more research must be done before this can be recommended. Purification Methods Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]   Succimer Preparation Products And Raw materials Raw materials meso-2,3-Dibromosuccinic acid