China Largest Manufacturer factory Supply 6,7-Dihydroxycoumarin/Esculetin CAS 305-01-1 CAS NO.305-01-1

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Esculetin Basic information Product Name: Esculetin Synonyms: CICHORIGENIN;CICHERINGENIN;ESCULETOL;ESCULETIN;LABOTEST-BB LT00233229;AESCULETIN;AKOS 215-98;6,7-DIHYDROXY-CHROMEN-2-ONE CAS: 305-01-1 MF: C9H6O4 MW: 178.14 EINECS: 206-161-5 Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Coumarin;Coumarins;Analytical Chemistry;Mass Spectrometry;Matrix Materials (MALDI-TOF-MS);Inhibitors;Fluorescent Mol File: 305-01-1.mol   Esculetin Chemical Properties Melting point  271-273 °C(lit.) Boiling point  270.35°C (rough estimate) density  1.3431 (rough estimate) refractive index  1.4500 (estimate) storage temp.  2-8°C solubility  Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid pka 1.71(at 25℃) form  powder color  Light yellow PH Range Weak blue uorescence (1.5) to strong blue uorescence (2.0) Water Solubility  slightly soluble Merck  14,3697 BRN  152788 Major Application antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness InChIKey ILEDWLMCKZNDJK-UHFFFAOYSA-N CAS DataBase Reference 305-01-1(CAS DataBase Reference) NIST Chemistry Reference Coumarin, 6,7-dihydroxy-(305-01-1) EPA Substance Registry System Esculetin (305-01-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  GN6382500 HS Code  29322090 MSDS Information Provider Language 6,7-Dihydroxycoumarin English ACROS English SigmaAldrich English ALFA English   Esculetin Usage And Synthesis Chemical Properties YELLOWISH CRYSTALLINE POWDER Uses antifungal, hepatoprotective, IL-1 inhibitor Uses In filters for absorption of ultraviolet light. Uses In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition. Definition ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. General Description Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes. Purification Methods It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]   Esculetin Preparation Products And Raw materials Raw materials 1,4-Benzoquinone-->[1,3]DIOXOLO[4,5-G]CHROMEN-6-ONE-->6,7-DIHYDROXYCOUMARIN-7-BENZYL ETHER-->Scopoletin-->3,4-DIHYDROXY-6-NITROBENZALDEHYDE-->Esculin-->2,4,5-TRIHYDROXYBENZALDEHYDE-->6-Hydroxycoumarin-->6-HYDROXY-7-METHOXYCOUMARIN-->1,2,4-Triacetoxybenzene-->7,8-DIHYDROXY-6-METHOXYCOUMARIN Preparation Products SCOPARONE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Esculetin Basic information Product Name: Esculetin Synonyms: CICHORIGENIN;CICHERINGENIN;ESCULETOL;ESCULETIN;LABOTEST-BB LT00233229;AESCULETIN;AKOS 215-98;6,7-DIHYDROXY-CHROMEN-2-ONE CAS: 305-01-1 MF: C9H6O4 MW: 178.14 EINECS: 206-161-5 Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Coumarin;Coumarins;Analytical Chemistry;Mass Spectrometry;Matrix Materials (MALDI-TOF-MS);Inhibitors;Fluorescent Mol File: 305-01-1.mol   Esculetin Chemical Properties Melting point  271-273 °C(lit.) Boiling point  270.35°C (rough estimate) density  1.3431 (rough estimate) refractive index  1.4500 (estimate) storage temp.  2-8°C solubility  Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid pka 1.71(at 25℃) form  powder color  Light yellow PH Range Weak blue uorescence (1.5) to strong blue uorescence (2.0) Water Solubility  slightly soluble Merck  14,3697 BRN  152788 Major Application antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness InChIKey ILEDWLMCKZNDJK-UHFFFAOYSA-N CAS DataBase Reference 305-01-1(CAS DataBase Reference) NIST Chemistry Reference Coumarin, 6,7-dihydroxy-(305-01-1) EPA Substance Registry System Esculetin (305-01-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  GN6382500 HS Code  29322090 MSDS Information Provider Language 6,7-Dihydroxycoumarin English ACROS English SigmaAldrich English ALFA English   Esculetin Usage And Synthesis Chemical Properties YELLOWISH CRYSTALLINE POWDER Uses antifungal, hepatoprotective, IL-1 inhibitor Uses In filters for absorption of ultraviolet light. Uses In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition. Definition ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. General Description Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes. Purification Methods It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]   Esculetin Preparation Products And Raw materials Raw materials 1,4-Benzoquinone-->[1,3]DIOXOLO[4,5-G]CHROMEN-6-ONE-->6,7-DIHYDROXYCOUMARIN-7-BENZYL ETHER-->Scopoletin-->3,4-DIHYDROXY-6-NITROBENZALDEHYDE-->Esculin-->2,4,5-TRIHYDROXYBENZALDEHYDE-->6-Hydroxycoumarin-->6-HYDROXY-7-METHOXYCOUMARIN-->1,2,4-Triacetoxybenzene-->7,8-DIHYDROXY-6-METHOXYCOUMARIN Preparation Products SCOPARONE