| Sulbutiamine Basic information |
| Product Name: |
Sulbutiamine |
| Synonyms: |
arcalion;BISIBUTIAMINE;SULBUTIAMINE;Bisibuthiamine;SULBUTIAMINE(ARCALION,BISIBUTIAMINE);O,O-Diisobutyrate;3,3'-Dithiobis[4-[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-formylamino]-3-penten-1-ol] bis(2-methylpropionate);Bis(2-methylpropionic acid)[dithiobis[3-[1-[[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino]ethylidene]-3,1-propanediyl]] ester |
| CAS: |
3286-46-2 |
| MF: |
C32H46N8O6S2 |
| MW: |
702.89 |
| EINECS: |
221-937-3 |
| Product Categories: |
API;Vitamins and derivatives |
| Mol File: |
3286-46-2.mol |
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| Sulbutiamine Chemical Properties |
| Melting point |
140.5-141.5 °C |
| Boiling point |
892.5±65.0 °C(Predicted) |
| density |
1.1323 (rough estimate) |
| refractive index |
1.7400 (estimate) |
| storage temp. |
under inert gas (nitrogen or Argon) at 2-8°C |
| solubility |
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka |
5.82±0.10(Predicted) |
| Merck |
14,9297 |
| Stability: |
Hygroscopic |
| CAS DataBase Reference |
3286-46-2(CAS DataBase Reference) |
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| Sulbutiamine Usage And Synthesis |
| Description |
Sulbutiamine is a vitamin B1 derivative developed by the French Servier Pharmaceuticals. The product is described in Special Drug Patent 5921M as a formulation with vitamin B1 activity, which is able to increase the blood level of vitamin B1 and has a therapeutic effect on all vitamin B1 deficiencies.
Sulbutiamine is a synthetic compound, which consists of two thiamine molecules bound together by a sulfur group. Due to the fact that sulbutiamine is a dimer of two thiamine molecules, it is a lipophilic drug that crosses the blood-brain barrier more quickly than thiamine(Farid and Abdelwahab,2016).Thus, sulbutiamine has neurotropic action and can increases the levels of thiamine and thiamine phosphate esters in the brain (Sevim et al.,2017). |
| Chemical Properties |
White Solid |
| Uses |
Sulbutiamine (isobutyryl thiamine disulfide) is a lipophilic derivative of thiamine used for the treatment of asthenia and other related pathological conditions. Sulbutiamine is available over-the-counter in several countries as a component of nutritional supplements. |
| benefits |
Sulbutiamine belongs to the class of medicines called an artificial vitamin. It contains Sulbutiamine, which is similar to vitamin B1 (thiamine). It is used for the symptomatic treatment of asthenia. SULBUTIAMINE works by increasing the thiamine levels in the brain. It is thought to have mild stimulant effects. Thereby it improves memory and reduces feelings of weakness. It may also be used in combination with other medicines to improve everyday activities in Alzheimer's disease. |
| Safety |
Sulbutiamine is a very safe drug, but its effects vary widely depending on the individual. Some people consider it too stimulating yet others find its effects sedative. Despite possible stimulation sulbutiamine is not thought to cause insomnia. Depression and anxiety have been reported occasionally. Large doses can cause headaches. No drug interactions or contraindications are known, but it has been suggested that people with bipolar disorder should not use sulbutiamine. |
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| Sulbutiamine Preparation Products And Raw materials |
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China (Mainland)
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