China Largest Factory Manufacturer sales D-Fructose 1,6-Diphosphate trisodium salt CAS 38099-82-0 CAS NO.38099-82-0

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D-Fructose 1,6-bisphosphate trisodium salt Basic information Biochem/physiol Actions Product Name: D-Fructose 1,6-bisphosphate trisodium salt Synonyms: acetic acid (12-acetyloxy-6,11-dioxo-1,2,3,4-tetrahydrotetracen-5-yl) ester;FDP-Na3H;D(+)FRUCTOFURANOSE 1,6-DIPHOSPHATE TRISODIUM SALT;D-FruCLose 1,6-bisphosphate trisodiuM salt;D-Fructose 1,6-bisphosphate hydrate trisodium salt;Harden-Young ester, Hexose diphosphate hydrate trisodium salt, D(+)Fructofuranose 1,6-diphosphate hydrate trisodium salt;D-Fructose-1,6-biphosphate trisodium salt octahydrate;HEXOSE DIPHOSPHATE TRISODIUM SALT CAS: 38099-82-0 MF: C6H15NaO12P2 MW: 364.11 EINECS: 253-778-0 Product Categories: Dextrins、Sugar & Carbohydrates;VX:15689727968 Mol File: 38099-82-0.mol   D-Fructose 1,6-bisphosphate trisodium salt Chemical Properties Melting point  127°C storage temp.  −20°C Water Solubility  Soluble in water at 50mg/ml EPA Substance Registry System D-Fructose, 1,6-bis(dihydrogen phosphate), trisodium salt (38099-82-0)   Safety Information WGK Germany  3 F  10-21 MSDS Information Provider Language SigmaAldrich English   D-Fructose 1,6-bisphosphate trisodium salt Usage And Synthesis Biochem/physiol Actions Fructose-1,6-biphosphate (F1,6P) is a glycolytic intermediate produced by the transfer of a phosphate from ATP to fructose-6-phosphate by the enzyme phosphofructokinase. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. During glycolysis, aldolase splits Fructose-1,6-biphosphate into dihydroxacetone phosphate (DHAP) and glyceraldehyde phosphate. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells. Uses D-Fructose-1,6-bisphosphate trisodium salt is used to reduce ischemia-reperfusion injury in rats. Application D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury. Purification Methods Fructose-1,6-diphosphate is best purified via the acid strychnine salt which is stable for several months. To remove the strychnine, dissolve 5g in H2O (150mL), and add 5N NaOH (or KOH to obtain the K salt) to pH 8.3 (phenolphthalein) with vigorous stirring. Remove the precipitate by centrifugation, wash with cold H2O (2x 25mL), extract with CHCl3 until the extract is free of strychnine (ca 8 to 10times, Mandelein spot test). Freeze-dry the aqueous solution to give the Na salt which is hygroscopic. It has been recrystallised from aqueous EtOH as the octahydrate, m 125o, [] D +2.6o (c 1, H2O). A neutral solution of the salt keeps well in a frozen state for over several months. [Neuberg et al. Arch Biochem 3 33 1943, Sable Biochemical Preparations 2 52 1952, Stumpf J Biol Chem 182 261 1950]. The calcium salt can be partially purified by dissolving in ice-cold N HCl (1g per 10mL) and re-precipitating by dropwise addition of 2N NaOH: the precipitate and supernatant are heated on a boiling water bath for a short time, then filtered, and the precipitate is washed with hot water. The magnesium salt can be precipitated from a cold aqueous solution by adding four volumes of EtOH. The tetramethyl ester is an oil with n D 1.4648, [] 18 +20.2 (c 0.4, MeOH). [Schulbach & Rauchenberger Chem Ber 60 1178 1927, Beilstein 1 IV 4424.]   D-Fructose 1,6-bisphosphate trisodium salt Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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D-Fructose 1,6-bisphosphate trisodium salt Basic information Biochem/physiol Actions Product Name: D-Fructose 1,6-bisphosphate trisodium salt Synonyms: acetic acid (12-acetyloxy-6,11-dioxo-1,2,3,4-tetrahydrotetracen-5-yl) ester;FDP-Na3H;D(+)FRUCTOFURANOSE 1,6-DIPHOSPHATE TRISODIUM SALT;D-FruCLose 1,6-bisphosphate trisodiuM salt;D-Fructose 1,6-bisphosphate hydrate trisodium salt;Harden-Young ester, Hexose diphosphate hydrate trisodium salt, D(+)Fructofuranose 1,6-diphosphate hydrate trisodium salt;D-Fructose-1,6-biphosphate trisodium salt octahydrate;HEXOSE DIPHOSPHATE TRISODIUM SALT CAS: 38099-82-0 MF: C6H15NaO12P2 MW: 364.11 EINECS: 253-778-0 Product Categories: Dextrins、Sugar & Carbohydrates;VX:15689727968 Mol File: 38099-82-0.mol   D-Fructose 1,6-bisphosphate trisodium salt Chemical Properties Melting point  127°C storage temp.  −20°C Water Solubility  Soluble in water at 50mg/ml EPA Substance Registry System D-Fructose, 1,6-bis(dihydrogen phosphate), trisodium salt (38099-82-0)   Safety Information WGK Germany  3 F  10-21 MSDS Information Provider Language SigmaAldrich English   D-Fructose 1,6-bisphosphate trisodium salt Usage And Synthesis Biochem/physiol Actions Fructose-1,6-biphosphate (F1,6P) is a glycolytic intermediate produced by the transfer of a phosphate from ATP to fructose-6-phosphate by the enzyme phosphofructokinase. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. During glycolysis, aldolase splits Fructose-1,6-biphosphate into dihydroxacetone phosphate (DHAP) and glyceraldehyde phosphate. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells. Uses D-Fructose-1,6-bisphosphate trisodium salt is used to reduce ischemia-reperfusion injury in rats. Application D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury. Purification Methods Fructose-1,6-diphosphate is best purified via the acid strychnine salt which is stable for several months. To remove the strychnine, dissolve 5g in H2O (150mL), and add 5N NaOH (or KOH to obtain the K salt) to pH 8.3 (phenolphthalein) with vigorous stirring. Remove the precipitate by centrifugation, wash with cold H2O (2x 25mL), extract with CHCl3 until the extract is free of strychnine (ca 8 to 10times, Mandelein spot test). Freeze-dry the aqueous solution to give the Na salt which is hygroscopic. It has been recrystallised from aqueous EtOH as the octahydrate, m 125o, [] D +2.6o (c 1, H2O). A neutral solution of the salt keeps well in a frozen state for over several months. [Neuberg et al. Arch Biochem 3 33 1943, Sable Biochemical Preparations 2 52 1952, Stumpf J Biol Chem 182 261 1950]. The calcium salt can be partially purified by dissolving in ice-cold N HCl (1g per 10mL) and re-precipitating by dropwise addition of 2N NaOH: the precipitate and supernatant are heated on a boiling water bath for a short time, then filtered, and the precipitate is washed with hot water. The magnesium salt can be precipitated from a cold aqueous solution by adding four volumes of EtOH. The tetramethyl ester is an oil with n D 1.4648, [] 18 +20.2 (c 0.4, MeOH). [Schulbach & Rauchenberger Chem Ber 60 1178 1927, Beilstein 1 IV 4424.]   D-Fructose 1,6-bisphosphate trisodium salt Preparation Products And Raw materials