China Largest Manufacturer factory sales D-Pyroglutamic Acid CAS 4042-36-8 CAS NO.4042-36-8

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D-Pyroglutamic acid Basic information Product Name: D-Pyroglutamic acid Synonyms: (R)-5-PYRROLIDONE-2-CARBOXYLIC ACID;(R)-(+)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXOPYRROLIDINE-2-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDONE-5-CARBOXYLIC ACID CAS: 4042-36-8 MF: C5H7NO3 MW: 129.11 EINECS: 223-735-0 Product Categories: Amino Acids & Derivatives;Chiral Reagents;Pyroglutamic acid [Pyr, pGu];Amino Acids 13C, 2H, 15N;Amino Acids;amino acid;Amino Acids and Derivatives;Heterocycles;chiral;Biochemistry;Biological-modified Amino Acids;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;pharmacetical Mol File: 4042-36-8.mol   D-Pyroglutamic acid Chemical Properties Melting point  155-162 °C alpha  27.5 º (c=10,1N NaOH) Boiling point  239.15°C (rough estimate) density  1.3816 (rough estimate) refractive index  10 ° (C=5, H2O) storage temp.  Sealed in dry,Room Temperature solubility  Dimethylformamide, DMSO (Slightly), Methanol (Slightly), Water form  Solid pka 3.48±0.20(Predicted) color  Off-White to Light Beige optical activity [α]22/D +10°, c = 1.5 in H2O Water Solubility  soluble Merck  14,8001 BRN  82133 InChIKey ODHCTXKNWHHXJC-GSVOUGTGSA-N CAS DataBase Reference 4042-36-8(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 HS Code  29339900 MSDS Information Provider Language ACROS English SigmaAldrich English ALFA English   D-Pyroglutamic acid Usage And Synthesis Chemical Properties white to light yellow crystal powde Uses Serves as a building block in the synthesis of diphthamide Uses Serves as a building block in the synthesis of diphthamide. Definition ChEBI: The D-enantiomer of 5-oxoproline. Purification Methods Purify R-pyroglutamic acid by dissolving it in H2O, filtering, passing the filtrate through Dowex 50 (H+ form), washing with H2O, pooling washings, evaporating, removing H2O azeotropically with Me2CO and *C6H6, washing the residue with Et2O and recrystallising from EtOH/pet ether. [Pradeller et al. Collect Czech Chem Commun 42 79, 80 1977, Beilstein 22/6 V 7.]   D-Pyroglutamic acid Preparation Products And Raw materials Raw materials 5-Hydroxymethylpyrrolidin-2-one-->L-Pyroglutamic acid-->D(-)-Glutamic acid-->(-)-D-PYROGLUTAMIC ACID METHYL ESTER Preparation Products L-Pyroglutamic acid-->Ethanol-->(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine-->FASORACETAM-->D-PYROGLUTAMIC ACID TERT-BUTYL ESTER

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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D-Pyroglutamic acid Basic information Product Name: D-Pyroglutamic acid Synonyms: (R)-5-PYRROLIDONE-2-CARBOXYLIC ACID;(R)-(+)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXOPYRROLIDINE-2-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDONE-5-CARBOXYLIC ACID CAS: 4042-36-8 MF: C5H7NO3 MW: 129.11 EINECS: 223-735-0 Product Categories: Amino Acids & Derivatives;Chiral Reagents;Pyroglutamic acid [Pyr, pGu];Amino Acids 13C, 2H, 15N;Amino Acids;amino acid;Amino Acids and Derivatives;Heterocycles;chiral;Biochemistry;Biological-modified Amino Acids;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;pharmacetical Mol File: 4042-36-8.mol   D-Pyroglutamic acid Chemical Properties Melting point  155-162 °C alpha  27.5 º (c=10,1N NaOH) Boiling point  239.15°C (rough estimate) density  1.3816 (rough estimate) refractive index  10 ° (C=5, H2O) storage temp.  Sealed in dry,Room Temperature solubility  Dimethylformamide, DMSO (Slightly), Methanol (Slightly), Water form  Solid pka 3.48±0.20(Predicted) color  Off-White to Light Beige optical activity [α]22/D +10°, c = 1.5 in H2O Water Solubility  soluble Merck  14,8001 BRN  82133 InChIKey ODHCTXKNWHHXJC-GSVOUGTGSA-N CAS DataBase Reference 4042-36-8(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 HS Code  29339900 MSDS Information Provider Language ACROS English SigmaAldrich English ALFA English   D-Pyroglutamic acid Usage And Synthesis Chemical Properties white to light yellow crystal powde Uses Serves as a building block in the synthesis of diphthamide Uses Serves as a building block in the synthesis of diphthamide. Definition ChEBI: The D-enantiomer of 5-oxoproline. Purification Methods Purify R-pyroglutamic acid by dissolving it in H2O, filtering, passing the filtrate through Dowex 50 (H+ form), washing with H2O, pooling washings, evaporating, removing H2O azeotropically with Me2CO and *C6H6, washing the residue with Et2O and recrystallising from EtOH/pet ether. [Pradeller et al. Collect Czech Chem Commun 42 79, 80 1977, Beilstein 22/6 V 7.]   D-Pyroglutamic acid Preparation Products And Raw materials Raw materials 5-Hydroxymethylpyrrolidin-2-one-->L-Pyroglutamic acid-->D(-)-Glutamic acid-->(-)-D-PYROGLUTAMIC ACID METHYL ESTER Preparation Products L-Pyroglutamic acid-->Ethanol-->(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine-->FASORACETAM-->D-PYROGLUTAMIC ACID TERT-BUTYL ESTER