China Largest Factory Manufacturer sales Sodium stearyl fumarate CAS 4070-80-8 CAS NO.4070-80-8

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Sodium Stearyl Fumarate Basic information Product Name: Sodium Stearyl Fumarate Synonyms: SODIUM STEARYL FUMARATE;sodium octadecyl fumarate;SodiumStearylFumarate(Excipient)OpenPartDmf;Sodium Stearyl Fumarate (Excipient);Monosodium stearyl fumarate;2-Butenedioic acid (2E)-, monooctadecyl ester, sodium salt;SODIUMSTEARYLFUMARATE,FCC;SODIUMSTEARYLFUMARATE,NF CAS: 4070-80-8 MF: C22H39NaO4 MW: 390.53 EINECS: 223-781-1 Product Categories:   Mol File: 4070-80-8.mol   Sodium Stearyl Fumarate Chemical Properties Melting point  >196°C (dec.) storage temp.  Inert atmosphere,Room Temperature solubility  Practically insoluble in water, slightly soluble in methanol, practically insoluble in acetone and in anhydrous ethanol. form  neat color  White to Off-White InChIKey GKCVIRALYIXVLE-RZLHGTIFSA-M   Safety Information Hazard Codes  Xi Risk Statements  36/38 Safety Statements  26 WGK Germany  3 HS Code  2917191600 MSDS Information   Sodium Stearyl Fumarate Usage And Synthesis Description Sodium Stearyl Fumarate (SSF) is used as a lubricant in tableting to reduce the friction between the tablet and the die wall and to prevent adhesion of the material to punches or the die wall in the pharmaceutical industries. It is used also as a lubricant in the manufacturing of capsules and other oral dosage forms. Sodium stearyl fumarate is also used in food production as a dough conditioner, a conditioning agent, and a stabilizing agent. Chemical Properties White or off-white crystalline powder Chemical Properties Sodium stearyl fumarate is a fine, white powder with agglomerates of flat, circular-shaped particles. Uses Sodium Stearyl Fumarate is a dough conditioner and conditioning agent that is a white powder practically insoluble in water. It is used as a dough conditioner in yeast-raised baked goods. It is used as a conditioning agent in dehydrated potatoes. It also functions as a maturing and bleaching agent. Uses cationic transfection agent, bile acid sequestrant, vaccine adjuvant, protein stabilizer Uses Binder Production Methods Stearyl alcohol is reacted with maleic anhydride. The product of this reaction then undergoes an isomerization step followed by salt formation to produce sodium stearyl fumarate. Pharmaceutical Applications Sodium stearyl fumarate is used as a lubricant in capsule and tablet formulations at 0.5–2.0% w/w concentration. It is also used in certain food applications. Safety Sodium stearyl fumarate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. Metabolic studies of sodium stearyl fumarate in the rat and dog indicated that approximately 80% was absorbed and 35% was rapidly metabolized. The fraction absorbed was hydrolyzed to stearyl alcohol and fumaric acid, with the stearyl alcohol further oxidized to stearic acid. In the dog, sodium stearyl fumarate that was not absorbed was excreted unchanged in the feces within 24 hours. Stearyl alcohol and stearic acid are naturally occurring constituents in various food products, while fumaric acid is a normal constituent of body tissue. Stearates and stearyl citrate have been reviewed by the WHO and an acceptable daily intake for stearyl citrate has been set at up to 50 mg/kg body-weight. The establishment of an acceptable daily intake for stearates and fumaric acid was thought unnecessary. Disodium fumarate has been reported to have a toxicity not greatly exceeding that of sodium chloride. storage At ambient temperature, sodium stearyl fumarate is stable for up to 3 years when stored in amber glass bottles with polyethylene screw caps. The bulk material should be stored in a well-closed container in a cool, dry place. Incompatibilities Sodium stearyl fumarate is reported to be incompatible with chlorhexidine acetate. Regulatory Status GRAS listed. Permitted by the FDA for direct addition to food for human consumption as a conditioning or stabilizing agent in various bakery products, flour-thickened foods, dehydrated potatoes, and processed cereals up to 0.2–1.0% by weight of the food. Included in nonparenteral medicines licensed in the UK. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients. References [1] Arne W. Hölzer and John Sjögren, Evaluation of sodium stearyl fumarate as a tablet lubricant, International Journal of Pharmaceutics, 1979, vol. 2, 145-153 [2] Holger Zorn and Peter Czermak, Biotechnology of Food and Feed Additives, 2014 [3] #   Sodium Stearyl Fumarate Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Sodium Stearyl Fumarate Basic information Product Name: Sodium Stearyl Fumarate Synonyms: SODIUM STEARYL FUMARATE;sodium octadecyl fumarate;SodiumStearylFumarate(Excipient)OpenPartDmf;Sodium Stearyl Fumarate (Excipient);Monosodium stearyl fumarate;2-Butenedioic acid (2E)-, monooctadecyl ester, sodium salt;SODIUMSTEARYLFUMARATE,FCC;SODIUMSTEARYLFUMARATE,NF CAS: 4070-80-8 MF: C22H39NaO4 MW: 390.53 EINECS: 223-781-1 Product Categories:   Mol File: 4070-80-8.mol   Sodium Stearyl Fumarate Chemical Properties Melting point  >196°C (dec.) storage temp.  Inert atmosphere,Room Temperature solubility  Practically insoluble in water, slightly soluble in methanol, practically insoluble in acetone and in anhydrous ethanol. form  neat color  White to Off-White InChIKey GKCVIRALYIXVLE-RZLHGTIFSA-M   Safety Information Hazard Codes  Xi Risk Statements  36/38 Safety Statements  26 WGK Germany  3 HS Code  2917191600 MSDS Information   Sodium Stearyl Fumarate Usage And Synthesis Description Sodium Stearyl Fumarate (SSF) is used as a lubricant in tableting to reduce the friction between the tablet and the die wall and to prevent adhesion of the material to punches or the die wall in the pharmaceutical industries. It is used also as a lubricant in the manufacturing of capsules and other oral dosage forms. Sodium stearyl fumarate is also used in food production as a dough conditioner, a conditioning agent, and a stabilizing agent. Chemical Properties White or off-white crystalline powder Chemical Properties Sodium stearyl fumarate is a fine, white powder with agglomerates of flat, circular-shaped particles. Uses Sodium Stearyl Fumarate is a dough conditioner and conditioning agent that is a white powder practically insoluble in water. It is used as a dough conditioner in yeast-raised baked goods. It is used as a conditioning agent in dehydrated potatoes. It also functions as a maturing and bleaching agent. Uses cationic transfection agent, bile acid sequestrant, vaccine adjuvant, protein stabilizer Uses Binder Production Methods Stearyl alcohol is reacted with maleic anhydride. The product of this reaction then undergoes an isomerization step followed by salt formation to produce sodium stearyl fumarate. Pharmaceutical Applications Sodium stearyl fumarate is used as a lubricant in capsule and tablet formulations at 0.5–2.0% w/w concentration. It is also used in certain food applications. Safety Sodium stearyl fumarate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. Metabolic studies of sodium stearyl fumarate in the rat and dog indicated that approximately 80% was absorbed and 35% was rapidly metabolized. The fraction absorbed was hydrolyzed to stearyl alcohol and fumaric acid, with the stearyl alcohol further oxidized to stearic acid. In the dog, sodium stearyl fumarate that was not absorbed was excreted unchanged in the feces within 24 hours. Stearyl alcohol and stearic acid are naturally occurring constituents in various food products, while fumaric acid is a normal constituent of body tissue. Stearates and stearyl citrate have been reviewed by the WHO and an acceptable daily intake for stearyl citrate has been set at up to 50 mg/kg body-weight. The establishment of an acceptable daily intake for stearates and fumaric acid was thought unnecessary. Disodium fumarate has been reported to have a toxicity not greatly exceeding that of sodium chloride. storage At ambient temperature, sodium stearyl fumarate is stable for up to 3 years when stored in amber glass bottles with polyethylene screw caps. The bulk material should be stored in a well-closed container in a cool, dry place. Incompatibilities Sodium stearyl fumarate is reported to be incompatible with chlorhexidine acetate. Regulatory Status GRAS listed. Permitted by the FDA for direct addition to food for human consumption as a conditioning or stabilizing agent in various bakery products, flour-thickened foods, dehydrated potatoes, and processed cereals up to 0.2–1.0% by weight of the food. Included in nonparenteral medicines licensed in the UK. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients. References [1] Arne W. Hölzer and John Sjögren, Evaluation of sodium stearyl fumarate as a tablet lubricant, International Journal of Pharmaceutics, 1979, vol. 2, 145-153 [2] Holger Zorn and Peter Czermak, Biotechnology of Food and Feed Additives, 2014 [3] #   Sodium Stearyl Fumarate Preparation Products And Raw materials