China Biggest Factory Manufacturer Supply LITHOCHOLIC ACID CAS 434-13-9 CAS NO.434-13-9

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LITHOCHOLIC ACID Basic information Product Name: LITHOCHOLIC ACID Synonyms: 17-beta-(1-Methyl-3-carboxypropyl)ethiocholan-3-alpha-ol;17beta-(1-methyl-3-carboxypropyl)etiocholan-3alpha-ol;BETA-CHOLANIC ACID-3-ALPHA-OL;HYDROYCHOLANIC ACID;3-HYDROXYCHOLANIC ACID;3ALPHA-HYDROXYCHOLANIC ACID;3ALPHA-HYDROXY-5BETA-CHOLANIC ACID;3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID CAS: 434-13-9 MF: C24H40O3 MW: 376.57 EINECS: 207-099-1 Product Categories: Inhibitors;Intermediates & Fine Chemicals;Steroids;Bile Acids;Biochemistry;Pharmaceuticals Mol File: 434-13-9.mol   LITHOCHOLIC ACID Chemical Properties Melting point  183-188 °C (lit.) alpha  D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer) Boiling point  445.09°C (rough estimate) density  1.0454 (rough estimate) refractive index  35.5 ° (C=1, EtOH) Fp  9℃ storage temp.  room temp solubility  Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly, Heate pka 4.76±0.10(Predicted) form  Powder color  White to off-white Water Solubility  18.83ug/L(25 ºC) Merck  5545 BRN  3217757 InChIKey SMEROWZSTRWXGI-HVATVPOCSA-N CAS DataBase Reference 434-13-9(CAS DataBase Reference) EPA Substance Registry System Lithocholic acid (434-13-9)   Safety Information Safety Statements  22-24/25 RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution WGK Germany  2 RTECS  FZ2275000 HS Code  29181998 Hazardous Substances Data 434-13-9(Hazardous Substances Data) MSDS Information Provider Language ACROS English SigmaAldrich English   LITHOCHOLIC ACID Usage And Synthesis Chemical Properties white to off-white powder Uses A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Uses LD50(mouse) 3900 mg/kg po Uses Cholagogue;Anticholelithogenic Uses Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. Definition ChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action. General Description Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder. Air & Water Reactions Insoluble in water. Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes. Fire Hazard Flash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible. Purification Methods Lithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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LITHOCHOLIC ACID Basic information Product Name: LITHOCHOLIC ACID Synonyms: 17-beta-(1-Methyl-3-carboxypropyl)ethiocholan-3-alpha-ol;17beta-(1-methyl-3-carboxypropyl)etiocholan-3alpha-ol;BETA-CHOLANIC ACID-3-ALPHA-OL;HYDROYCHOLANIC ACID;3-HYDROXYCHOLANIC ACID;3ALPHA-HYDROXYCHOLANIC ACID;3ALPHA-HYDROXY-5BETA-CHOLANIC ACID;3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID CAS: 434-13-9 MF: C24H40O3 MW: 376.57 EINECS: 207-099-1 Product Categories: Inhibitors;Intermediates & Fine Chemicals;Steroids;Bile Acids;Biochemistry;Pharmaceuticals Mol File: 434-13-9.mol   LITHOCHOLIC ACID Chemical Properties Melting point  183-188 °C (lit.) alpha  D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer) Boiling point  445.09°C (rough estimate) density  1.0454 (rough estimate) refractive index  35.5 ° (C=1, EtOH) Fp  9℃ storage temp.  room temp solubility  Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly, Heate pka 4.76±0.10(Predicted) form  Powder color  White to off-white Water Solubility  18.83ug/L(25 ºC) Merck  5545 BRN  3217757 InChIKey SMEROWZSTRWXGI-HVATVPOCSA-N CAS DataBase Reference 434-13-9(CAS DataBase Reference) EPA Substance Registry System Lithocholic acid (434-13-9)   Safety Information Safety Statements  22-24/25 RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution WGK Germany  2 RTECS  FZ2275000 HS Code  29181998 Hazardous Substances Data 434-13-9(Hazardous Substances Data) MSDS Information Provider Language ACROS English SigmaAldrich English   LITHOCHOLIC ACID Usage And Synthesis Chemical Properties white to off-white powder Uses A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Uses LD50(mouse) 3900 mg/kg po Uses Cholagogue;Anticholelithogenic Uses Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. Definition ChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action. General Description Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder. Air & Water Reactions Insoluble in water. Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes. Fire Hazard Flash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible. Purification Methods Lithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]