China Largest Manufacturer factory sales L-5-Hydroxytryptophan CAS 4350-09-8 CAS NO.4350-09-8

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L-5-Hydroxytryptophan Basic information Product Name: L-5-Hydroxytryptophan Synonyms: 5-hydroxy-l-tryptopha;pretonine;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HYDROXYTRYPTOPHAN HYDRATE;L-5-HYDROXYTRYPTOPHAN;L-5-HTP;2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPIONIC ACID;(-)-5-HYDROXY-L-TRYPTOPHAN CAS: 4350-09-8 MF: C11H12N2O3 MW: 220.22 EINECS: 224-411-1 Product Categories: Amino Acids;Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Amino acidsPeptide Synthesis;Biochemicals Found in Plants;Nutrition Research;natural product;Inhibitors;Tryptophan Derivatives;Unnatural Amino Acid Derivatives;Amines;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Amines, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;amino;Other APIs Mol File: 4350-09-8.mol   L-5-Hydroxytryptophan Chemical Properties Melting point  270 °C (dec.) (lit.) alpha  -32.5 º (c=1,H2O on dry basis) Boiling point  361.16°C (rough estimate) density  0.902 g/mL at 25 °C (lit.) refractive index  n20/D 1.4850(lit.) Fp  175 °F storage temp.  2-8°C solubility  H2O: 10 mg/mL form  solid pka 2.22±0.10(Predicted) color  white optical activity [α]22/D 30°, c = 1 in H2O Water Solubility  Slightly soluble Merck  14,4847 BRN  88200 CAS DataBase Reference 4350-09-8(CAS DataBase Reference) EPA Substance Registry System L-5-Hydroxytryptophan (4350-09-8)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-65-20/21/22-20/21 Safety Statements  36-26 RIDADR  UN 2811 6.1/PG 3 WGK Germany  3 RTECS  YN7110000 F  3-10 TSCA  Yes HazardClass  6.1 PackingGroup  III HS Code  29339990 MSDS Information Provider Language L-5-Hydroxytryptophan English SigmaAldrich English ACROS English ALFA English   L-5-Hydroxytryptophan Usage And Synthesis Chemical Properties white to pale grey powder Uses A labelled metabolite of Tryptophan Uses 5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan Uses 5-Hydroxy-L-tryptophan has been used: to inject experimental mice for serotonin detection as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis General Description Colorless to pale pink crystals. Air & Water Reactions L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble . Reactivity Profile L-5-Hydroxytryptophan reacts with bases. . Fire Hazard Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible. Biochem/physiol Actions Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache. Purification Methods Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]   L-5-Hydroxytryptophan Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-5-Hydroxytryptophan Basic information Product Name: L-5-Hydroxytryptophan Synonyms: 5-hydroxy-l-tryptopha;pretonine;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HYDROXYTRYPTOPHAN HYDRATE;L-5-HYDROXYTRYPTOPHAN;L-5-HTP;2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPIONIC ACID;(-)-5-HYDROXY-L-TRYPTOPHAN CAS: 4350-09-8 MF: C11H12N2O3 MW: 220.22 EINECS: 224-411-1 Product Categories: Amino Acids;Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Amino acidsPeptide Synthesis;Biochemicals Found in Plants;Nutrition Research;natural product;Inhibitors;Tryptophan Derivatives;Unnatural Amino Acid Derivatives;Amines;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Amines, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;amino;Other APIs Mol File: 4350-09-8.mol   L-5-Hydroxytryptophan Chemical Properties Melting point  270 °C (dec.) (lit.) alpha  -32.5 º (c=1,H2O on dry basis) Boiling point  361.16°C (rough estimate) density  0.902 g/mL at 25 °C (lit.) refractive index  n20/D 1.4850(lit.) Fp  175 °F storage temp.  2-8°C solubility  H2O: 10 mg/mL form  solid pka 2.22±0.10(Predicted) color  white optical activity [α]22/D 30°, c = 1 in H2O Water Solubility  Slightly soluble Merck  14,4847 BRN  88200 CAS DataBase Reference 4350-09-8(CAS DataBase Reference) EPA Substance Registry System L-5-Hydroxytryptophan (4350-09-8)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-65-20/21/22-20/21 Safety Statements  36-26 RIDADR  UN 2811 6.1/PG 3 WGK Germany  3 RTECS  YN7110000 F  3-10 TSCA  Yes HazardClass  6.1 PackingGroup  III HS Code  29339990 MSDS Information Provider Language L-5-Hydroxytryptophan English SigmaAldrich English ACROS English ALFA English   L-5-Hydroxytryptophan Usage And Synthesis Chemical Properties white to pale grey powder Uses A labelled metabolite of Tryptophan Uses 5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan Uses 5-Hydroxy-L-tryptophan has been used: to inject experimental mice for serotonin detection as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis General Description Colorless to pale pink crystals. Air & Water Reactions L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble . Reactivity Profile L-5-Hydroxytryptophan reacts with bases. . Fire Hazard Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible. Biochem/physiol Actions Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache. Purification Methods Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]   L-5-Hydroxytryptophan Preparation Products And Raw materials