China Largest Factory Manufacturer sales NOBILETIN CAS 478-01-3 CAS NO.478-01-3

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NOBILETIN Basic information Description Source Uses structure and hydrogen bonding Application Product Name: NOBILETIN Synonyms: biletin;Nobiletin, 98%, from Citrus nobilis Lour.;Nobiletin, froM Citrus nobilis Lour.;Chuanpi glycosides;4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-;Nobiletin, >=98%;NOBILETIN;3',4',5,6,7,8-HEXAMETHOXYFLAVONE CAS: 478-01-3 MF: C21H22O8 MW: 402.39 EINECS:   Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;natural product;Inhibitors;CITRIMORE;Hexa-substituted Flavones;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 478-01-3.mol   NOBILETIN Chemical Properties Melting point  136.0 to 140.0 °C Boiling point  587.9±50.0 °C(Predicted) density  1.244±0.06 g/cm3(Predicted) storage temp.  Sealed in dry,Store in freezer, under -20°C solubility  Soluble in DMSO (up to 10 mg/ml) form  neat color  White BRN  360887 Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. InChIKey MRIAQLRQZPPODS-UHFFFAOYSA-N CAS DataBase Reference 478-01-3(CAS DataBase Reference)   Safety Information Safety Statements  24/25 WGK Germany  3 RTECS  DJ3052200 HS Code  29329990 MSDS Information   NOBILETIN Usage And Synthesis Description Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.     Source Nobiletin is a nonpolar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin). Uses NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. structure and hydrogen bonding The crystal structure study on NOB shows that the chromene and the arene rings are almost in the same plane. The C atoms of the two methoxy groups in the arene ring are also in the same plane, while the C atoms of four methoxy groups linking to the chromene ring are not in parallel. This conformational characteristic of chiral structure is indicated by the covalent bond rotation between the arene and the chromene rings and the conformational alternations of methoxy groups. Application Nobiletin has been shown to exhibit antioxidant, anti-inflammatory, antitumor/cancer, and antiangiogenic activity in vitro and in vivo. Animal and in vitro data also demonstrate nobiletin's potential ability to suppress bone loss, lower cholesterol and atherosclerosis, and improve hyperglycemia and insulin resistance. Description Nobiletin (478-01-3) is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5. Chemical Properties White powder Uses matrix metaloproteinase inhibitor; antineoplastic Uses Nobiletin is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. It is a potent antioxidant with good bioavailability. Nobiletin directly inhibits the ATP-binding cassette proteins P-glycoprotein and breast cancer resistance protein. Definition ChEBI: A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively. References 1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610 2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446 3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814 4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683 5) Walle (2007), Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass ; Semin. Cancer Biol. 17 354   NOBILETIN Preparation Products And Raw materials Raw materials Phenol, 2,3,4-trimethoxy-, 1-formate-->1,2,3,4-TETRAMETHOXYBENZENE-->1,3-Propanedione, 1-(3,4-dimethoxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)--->4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,8-dihydroxy-6,7-dimethoxy--->1-(3,4-dimethoxybenzoyl)-1H-1,2,3-benzotriazole-->Phenol, 2,3,4,5-tetramethoxy--->1-(2-hydroxy-3,4,6-trimethoxy-phenyl)ethanone-->1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)ethanone-->Pentamethoxybenzene-->1,2,3,5-TETRAMETHOXYBENZENE-->3,4-DIMETHOXYBENZOYL CHLORIDE-->2,3,4-Trimethoxybenzaldehyde-->3,4-Dimethoxybenzoic acid-->1,2,3-Trimethoxybenzene

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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NOBILETIN Basic information Description Source Uses structure and hydrogen bonding Application Product Name: NOBILETIN Synonyms: biletin;Nobiletin, 98%, from Citrus nobilis Lour.;Nobiletin, froM Citrus nobilis Lour.;Chuanpi glycosides;4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-;Nobiletin, >=98%;NOBILETIN;3',4',5,6,7,8-HEXAMETHOXYFLAVONE CAS: 478-01-3 MF: C21H22O8 MW: 402.39 EINECS:   Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;natural product;Inhibitors;CITRIMORE;Hexa-substituted Flavones;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 478-01-3.mol   NOBILETIN Chemical Properties Melting point  136.0 to 140.0 °C Boiling point  587.9±50.0 °C(Predicted) density  1.244±0.06 g/cm3(Predicted) storage temp.  Sealed in dry,Store in freezer, under -20°C solubility  Soluble in DMSO (up to 10 mg/ml) form  neat color  White BRN  360887 Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. InChIKey MRIAQLRQZPPODS-UHFFFAOYSA-N CAS DataBase Reference 478-01-3(CAS DataBase Reference)   Safety Information Safety Statements  24/25 WGK Germany  3 RTECS  DJ3052200 HS Code  29329990 MSDS Information   NOBILETIN Usage And Synthesis Description Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.     Source Nobiletin is a nonpolar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin). Uses NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation. structure and hydrogen bonding The crystal structure study on NOB shows that the chromene and the arene rings are almost in the same plane. The C atoms of the two methoxy groups in the arene ring are also in the same plane, while the C atoms of four methoxy groups linking to the chromene ring are not in parallel. This conformational characteristic of chiral structure is indicated by the covalent bond rotation between the arene and the chromene rings and the conformational alternations of methoxy groups. Application Nobiletin has been shown to exhibit antioxidant, anti-inflammatory, antitumor/cancer, and antiangiogenic activity in vitro and in vivo. Animal and in vitro data also demonstrate nobiletin's potential ability to suppress bone loss, lower cholesterol and atherosclerosis, and improve hyperglycemia and insulin resistance. Description Nobiletin (478-01-3) is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORα/γ. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5. Chemical Properties White powder Uses matrix metaloproteinase inhibitor; antineoplastic Uses Nobiletin is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. It is a potent antioxidant with good bioavailability. Nobiletin directly inhibits the ATP-binding cassette proteins P-glycoprotein and breast cancer resistance protein. Definition ChEBI: A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively. References 1) He et al. (2016), The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism, 23 610 2) Mulvihill et al. (2011), Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes 60 1446 3) Cui et al. (2010), Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull., 33 1814 4) Nagase et al. (2005), Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry 44 13683 5) Walle (2007), Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass ; Semin. Cancer Biol. 17 354   NOBILETIN Preparation Products And Raw materials Raw materials Phenol, 2,3,4-trimethoxy-, 1-formate-->1,2,3,4-TETRAMETHOXYBENZENE-->1,3-Propanedione, 1-(3,4-dimethoxyphenyl)-3-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)--->4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,8-dihydroxy-6,7-dimethoxy--->1-(3,4-dimethoxybenzoyl)-1H-1,2,3-benzotriazole-->Phenol, 2,3,4,5-tetramethoxy--->1-(2-hydroxy-3,4,6-trimethoxy-phenyl)ethanone-->1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)ethanone-->Pentamethoxybenzene-->1,2,3,5-TETRAMETHOXYBENZENE-->3,4-DIMETHOXYBENZOYL CHLORIDE-->2,3,4-Trimethoxybenzaldehyde-->3,4-Dimethoxybenzoic acid-->1,2,3-Trimethoxybenzene