China Largest Manufacturer factory Supply Biochanin A CAS 491-80-5 CAS NO.491-80-5

                                PRODUCT DETAILS       

5,7-Dihydrox -4'-methoxyisoflavone Basic information Product Name: 5,7-Dihydrox -4'-methoxyisoflavone Synonyms: Biochani,Olmelin;5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one;BIOCHANIN A (AHP);BIOCHANIN;5,7-DIHYDROXY-4''-METHOXYISOFLAVONE, 98% BIOCHANIN A;5,7-Dihydrox -4'-methoxyisoflavone;5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one;Biochanin A, (5,7-Dihydroxy-4’-methoxyisoflavone) CAS: 491-80-5 MF: C16H12O5 MW: 284.26 EINECS: 207-744-7 Product Categories: chemical reagent;pharmaceutical intermediate;Iso-Flavones;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors Mol File: 491-80-5.mol   5,7-Dihydrox -4'-methoxyisoflavone Chemical Properties Melting point  210-213 °C(lit.) Boiling point  340-355 °C(Press: 0.5 Torr) density  1.420±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  acetone: 10 mg/mL, clear, brown form  Powder pka 6.50±0.20(Predicted) color  Off-White to Beige Water Solubility  Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C). λmax 263nm(EtOH)(lit.) BRN  278107 CAS DataBase Reference 491-80-5(CAS DataBase Reference) EPA Substance Registry System 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)- (491-80-5)   Safety Information Safety Statements  22-24/25 WGK Germany  3 RTECS  DJ3002500 F  10 TSCA  Yes HS Code  29329990 MSDS Information Provider Language SigmaAldrich English ALFA English   5,7-Dihydrox -4'-methoxyisoflavone Usage And Synthesis Description Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein (Item No. 10005167), another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 μM). Chemical Properties Off-White Solid Uses phytoestrogen Uses It has putative benefits in dietary cancer prophylaxis. It has also been found to inhibit fatty acid amide hydrolase and to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2. It acts as an antineoplastic agent. It is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects. It is a nitric oxide synthase inhibitor and apoptosis inducer Uses An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene General Description Biochanin A (BCA) is synthesized in vitro from phloroglucinol. A series of steps involving Friedel Crafts reaction results in an intermediate product 1-(2,4,6-trihydroxyphenyl)-2-(4 methoxyphenyl) ethanone, which post cyclization leads to BCA. It is catabolized to isoflavone genistein post ingestion. Biochem/physiol Actions Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects.   5,7-Dihydrox -4'-methoxyisoflavone Preparation Products And Raw materials Raw materials 1-(2,4,6-Trihydroxyphenyl)-2-(4-methoxyphenyl)ethanone-->2,4,6-TRIHYDROXYBENZALDEHYDE-->2-Bromo-4'-methoxyacetophenone Preparation Products D(+)-Glucose

                                                                         About US 

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                      Our Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

5,7-Dihydrox -4'-methoxyisoflavone Basic information Product Name: 5,7-Dihydrox -4'-methoxyisoflavone Synonyms: Biochani,Olmelin;5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one;BIOCHANIN A (AHP);BIOCHANIN;5,7-DIHYDROXY-4''-METHOXYISOFLAVONE, 98% BIOCHANIN A;5,7-Dihydrox -4'-methoxyisoflavone;5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one;Biochanin A, (5,7-Dihydroxy-4’-methoxyisoflavone) CAS: 491-80-5 MF: C16H12O5 MW: 284.26 EINECS: 207-744-7 Product Categories: chemical reagent;pharmaceutical intermediate;Iso-Flavones;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors Mol File: 491-80-5.mol   5,7-Dihydrox -4'-methoxyisoflavone Chemical Properties Melting point  210-213 °C(lit.) Boiling point  340-355 °C(Press: 0.5 Torr) density  1.420±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  acetone: 10 mg/mL, clear, brown form  Powder pka 6.50±0.20(Predicted) color  Off-White to Beige Water Solubility  Soluble in water (<1 mg/ml at 25°C), chloroform, methanol, DMSO (57 mg/ml at 25°C), and ethanol (9 mg/ml at 25°C). λmax 263nm(EtOH)(lit.) BRN  278107 CAS DataBase Reference 491-80-5(CAS DataBase Reference) EPA Substance Registry System 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-methoxyphenyl)- (491-80-5)   Safety Information Safety Statements  22-24/25 WGK Germany  3 RTECS  DJ3002500 F  10 TSCA  Yes HS Code  29329990 MSDS Information Provider Language SigmaAldrich English ALFA English   5,7-Dihydrox -4'-methoxyisoflavone Usage And Synthesis Description Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein (Item No. 10005167), another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 μM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 μM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 μM). Chemical Properties Off-White Solid Uses phytoestrogen Uses It has putative benefits in dietary cancer prophylaxis. It has also been found to inhibit fatty acid amide hydrolase and to act as agonist of PPARgamma, nuclear receptor that is current pharmacological target for the treatment of diabetes type 2. It acts as an antineoplastic agent. It is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects. It is a nitric oxide synthase inhibitor and apoptosis inducer Uses An isoflavone with anticancer proliferation, differentiation and chemopreventitive properties. Inhibits metabolic activation of benzo[a]pyrene General Description Biochanin A (BCA) is synthesized in vitro from phloroglucinol. A series of steps involving Friedel Crafts reaction results in an intermediate product 1-(2,4,6-trihydroxyphenyl)-2-(4 methoxyphenyl) ethanone, which post cyclization leads to BCA. It is catabolized to isoflavone genistein post ingestion. Biochem/physiol Actions Biochanin A is an isoflavone phytoestrogen found in red clover (Trifolium pratense) that is a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. In line with its low activity at ER-α estrogen receptors, it is essentially devoid of uterotrophic activity. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR). It reduces arterial resistance and enhances microcirculation perhaps via effects on potassium and/or calcium ion channels. Induction of sulfotransferases for xenobiotic detoxification has been proposed as a mechanism of its cancer preventive effects.   5,7-Dihydrox -4'-methoxyisoflavone Preparation Products And Raw materials Raw materials 1-(2,4,6-Trihydroxyphenyl)-2-(4-methoxyphenyl)ethanone-->2,4,6-TRIHYDROXYBENZALDEHYDE-->2-Bromo-4'-methoxyacetophenone Preparation Products D(+)-Glucose