China Biggest Manufacturer factory sales Nordihydroguaiaretic Acid CAS 500-38-9 CAS NO.500-38-9

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Nordihydroguaiaretic acid Basic information Description Reference Product Name: Nordihydroguaiaretic acid Synonyms: 4,4’-(2,3-dimethyltetramethylene)di-pyrocatecho;beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane;Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-;dihydro-dinorguaiareticaci;Dihydronorguaiaretic acid;dihydro-norguaiareticaci;dihydronorguaiareticacid;Dinorguaiaretic acid, dihydro- CAS: 500-38-9 MF: C18H22O4 MW: 302.36 EINECS: 207-903-0 Product Categories: Aromatics;Inhibitors;Aromatic Phenols;Intermediates & Fine Chemicals;Pharmaceuticals Mol File: 500-38-9.mol   Nordihydroguaiaretic acid Chemical Properties Melting point  184-186 °C (lit.) Boiling point  363.4°C (rough estimate) density  1.0772 (rough estimate) refractive index  1.4230 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  DMSO (Slightly), Methanol (Slightly) pka 9.56±0.10(Predicted) form  Powder color  White to off-white Water Solubility  slightly soluble Merck  14,6693 BRN  2056825 Stability: Stable. Incompatible with oxidizing agents. CAS DataBase Reference 500-38-9(CAS DataBase Reference) NIST Chemistry Reference Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-(500-38-9) EPA Substance Registry System Nordihydroguaiaretic acid (500-38-9)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38 Safety Statements  26-36/37-37/39-24/25-22 WGK Germany  3 RTECS  UX1750000 HS Code  29072990 MSDS Information Provider Language ACROS English SigmaAldrich English ALFA English   Nordihydroguaiaretic acid Usage And Synthesis Description Nordihydroguaiaretic acid is a kind of antioxidant compound presented in the creosoten bush. It is a potent in vitro scavenger of many kind of oxidants such as peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid. Studies have shown that it has various physiological effects. It can also protect hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation. Rat study has shown that it can block the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate. Two most exciting results are that: (1) it has the potential to increase lifespan of animals; (2) it can suppress growth of breast cancer cells through inhibiting the IGF-1 and c-erbB2/HER/NEU receptors. Reference Floriano-Sánchez, E, et al. "Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs." Free Radical Research 40.5(2006):523. Goodman, Yadong, et al. "Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation." Brain Research 654.1(1994):171. Lynch, M. A., M. L. Errington, and T. V. Bliss. "Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: an in vivo study in the dentate gyrus of the rat." Neuroscience 30.3(1989):693-701. Strong, Randy, et al. "Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice." Aging Cell 7.5(2008):641-650. Youngren, Jack F., et al. "Nordihydroguaiaretic Acid (NDGA) Inhibits the IGF-1 and c-erbB2/HER2/neu Receptors and Suppresses Growth in Breast Cancer Cells." Breast Cancer Research & Treatment 94.1(2005):37-46. Description Nordihydroguaiaretic acid (NDGA) is a grayish-white crystalline compound that was widely used as an antioxidant in animal fats in the 1950s and 1960s. It possesses phenolic properties similar to gallates, including their advantages and disadvantages. Besides the isolation of natural material (resinous exudate of creosote bush), NDGA has also been chemically synthesized. As the result of unfavorable toxicological findings, NDGA is prohibited from use in the US. More specifically, NDGA is a potent lipoxygenase inhibitor which interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carbox- ylesterase,and,to a lesser extent, cyclooxygenase. Chemical Properties light yellow crystalline solid Uses Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Inhibitor of broad bean lipoxygenase. The oxidation product from Resveratrol (R150000) showed a high inhibitory activity, w hereas Resveratrol itself had no activity and its oxidation efficiency was low. Uses Nordihydroguaiaretic acid is used in the treatment of multiple diseases, including cardiovascular diseases, neurological disorders and cancers. It is also used as an antioxidant. Uses Nordihydroguaiaretic acid (NDGA) is an antioxidant that has poor solubility and shows evidence of discoloration in the presence of metal salts. It is used to a limited extent to retard rancidity. Definition ChEBI: A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor. General Description Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS). Hazard Use in foods prohibited by FDA. Biochem/physiol Actions Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Safety Profile Moderately toxic by intraperitoneal route. An antioxidant food additive. When heated to decomposition it emits acrid smoke and irritating fumes. Purification Methods Crystallise the acid from dilute acetic acid. [Beilstein 6 IV 7771.]   Nordihydroguaiaretic acid Preparation Products And Raw materials Raw materials GUM GUAIAC-->3,4-Dimethoxyphenylacetone Preparation Products FW 358.2-->p-Hydroxy-cinnamic acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Nordihydroguaiaretic acid Basic information Description Reference Product Name: Nordihydroguaiaretic acid Synonyms: 4,4’-(2,3-dimethyltetramethylene)di-pyrocatecho;beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane;Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-;dihydro-dinorguaiareticaci;Dihydronorguaiaretic acid;dihydro-norguaiareticaci;dihydronorguaiareticacid;Dinorguaiaretic acid, dihydro- CAS: 500-38-9 MF: C18H22O4 MW: 302.36 EINECS: 207-903-0 Product Categories: Aromatics;Inhibitors;Aromatic Phenols;Intermediates & Fine Chemicals;Pharmaceuticals Mol File: 500-38-9.mol   Nordihydroguaiaretic acid Chemical Properties Melting point  184-186 °C (lit.) Boiling point  363.4°C (rough estimate) density  1.0772 (rough estimate) refractive index  1.4230 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  DMSO (Slightly), Methanol (Slightly) pka 9.56±0.10(Predicted) form  Powder color  White to off-white Water Solubility  slightly soluble Merck  14,6693 BRN  2056825 Stability: Stable. Incompatible with oxidizing agents. CAS DataBase Reference 500-38-9(CAS DataBase Reference) NIST Chemistry Reference Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-(500-38-9) EPA Substance Registry System Nordihydroguaiaretic acid (500-38-9)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38 Safety Statements  26-36/37-37/39-24/25-22 WGK Germany  3 RTECS  UX1750000 HS Code  29072990 MSDS Information Provider Language ACROS English SigmaAldrich English ALFA English   Nordihydroguaiaretic acid Usage And Synthesis Description Nordihydroguaiaretic acid is a kind of antioxidant compound presented in the creosoten bush. It is a potent in vitro scavenger of many kind of oxidants such as peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid. Studies have shown that it has various physiological effects. It can also protect hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation. Rat study has shown that it can block the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate. Two most exciting results are that: (1) it has the potential to increase lifespan of animals; (2) it can suppress growth of breast cancer cells through inhibiting the IGF-1 and c-erbB2/HER/NEU receptors. Reference Floriano-Sánchez, E, et al. "Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs." Free Radical Research 40.5(2006):523. Goodman, Yadong, et al. "Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation." Brain Research 654.1(1994):171. Lynch, M. A., M. L. Errington, and T. V. Bliss. "Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: an in vivo study in the dentate gyrus of the rat." Neuroscience 30.3(1989):693-701. Strong, Randy, et al. "Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice." Aging Cell 7.5(2008):641-650. Youngren, Jack F., et al. "Nordihydroguaiaretic Acid (NDGA) Inhibits the IGF-1 and c-erbB2/HER2/neu Receptors and Suppresses Growth in Breast Cancer Cells." Breast Cancer Research & Treatment 94.1(2005):37-46. Description Nordihydroguaiaretic acid (NDGA) is a grayish-white crystalline compound that was widely used as an antioxidant in animal fats in the 1950s and 1960s. It possesses phenolic properties similar to gallates, including their advantages and disadvantages. Besides the isolation of natural material (resinous exudate of creosote bush), NDGA has also been chemically synthesized. As the result of unfavorable toxicological findings, NDGA is prohibited from use in the US. More specifically, NDGA is a potent lipoxygenase inhibitor which interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carbox- ylesterase,and,to a lesser extent, cyclooxygenase. Chemical Properties light yellow crystalline solid Uses Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Inhibitor of broad bean lipoxygenase. The oxidation product from Resveratrol (R150000) showed a high inhibitory activity, w hereas Resveratrol itself had no activity and its oxidation efficiency was low. Uses Nordihydroguaiaretic acid is used in the treatment of multiple diseases, including cardiovascular diseases, neurological disorders and cancers. It is also used as an antioxidant. Uses Nordihydroguaiaretic acid (NDGA) is an antioxidant that has poor solubility and shows evidence of discoloration in the presence of metal salts. It is used to a limited extent to retard rancidity. Definition ChEBI: A tetrol that is butane which is substituted at positions 2 and 3 by 3,4-dihydroxybenzyl groups. Masoprocol, the meso-form found in the leaves of the creosote bush (Larrea divaricata), is a potent lipoxygenase inhibitor. General Description Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS). Hazard Use in foods prohibited by FDA. Biochem/physiol Actions Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure. Safety Profile Moderately toxic by intraperitoneal route. An antioxidant food additive. When heated to decomposition it emits acrid smoke and irritating fumes. Purification Methods Crystallise the acid from dilute acetic acid. [Beilstein 6 IV 7771.]   Nordihydroguaiaretic acid Preparation Products And Raw materials Raw materials GUM GUAIAC-->3,4-Dimethoxyphenylacetone Preparation Products FW 358.2-->p-Hydroxy-cinnamic acid