The world Biggest Manufacturer factory sales L-Hydroxyproline CAS 51-35-4 CAS NO.51-35-4

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L-Hydroxyproline Basic information Product Name: L-Hydroxyproline Synonyms: H-HYP-OH;H-HYP-OH (TRANS);H-L-HYDROXYPROLINE;H-L-HYP-OH;H-TRANS-HYP-OH;HYDROXYPROLINE;HYDROXY-L-PROLINE;HYDROXY-L-PROLINE, TRANS-4- CAS: 51-35-4 MF: C5H9NO3 MW: 131.13 EINECS: 200-091-9 Product Categories: Amino Acids;Pyrrole&Pyrrolidine&Pyrroline;Hydroxyproline [Hyp];Unusual Amino Acids;Biochemistry;Biological-modified Amino Acids;Nitrogen cyclic compounds;PHARMACEUTICALS;Amino Acids;L-Amino Acids;Amino Acids & Derivatives;Chiral Reagents;Heterocycles Mol File: 51-35-4.mol   L-Hydroxyproline Chemical Properties Melting point  273 °C (dec.)(lit.) alpha  -75.5 º (c=5, H2O) Boiling point  242.42°C (rough estimate) density  1.3121 (rough estimate) vapor density  4.5 (vs air) refractive index  -75.5 ° (C=4, H2O) storage temp.  Store below +30°C. solubility  H2O: 50 mg/mL form  Crystals or Crystalline Powder pka 1.82, 9.66(at 25℃) color  White PH 5.5-6.5 (50g/l, H2O, 20℃) Odor Odorless optical activity [α]25/D 75.6°, c = 1 in H2O Water Solubility  357.8 g/L (20 º C) Merck  14,4840 BRN  471933 InChIKey PMMYEEVYMWASQN-DMTCNVIQSA-N CAS DataBase Reference 51-35-4(CAS DataBase Reference) NIST Chemistry Reference Hydroxyproline(51-35-4) EPA Substance Registry System trans-4-Hydroxy-L-proline (51-35-4)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  24/25-36/37/39-27-26 WGK Germany  3 RTECS  TW3586500 Hazard Note  Irritant TSCA  Yes HazardClass  IRRITANT HS Code  29339990 MSDS Information Provider Language (2S,4R)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid English SigmaAldrich English ACROS English ALFA English   L-Hydroxyproline Usage And Synthesis Description A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys. Chemical Properties White crystalline powder Uses A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline. Uses A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins. Uses hydroxyproline is a skin-conditioning amino acid. It is a component of collagen. Definition ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration. Production Methods In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix. Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients. Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines. General Description Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards Biochem/physiol Actions Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues. Purification Methods Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]   L-Hydroxyproline Preparation Products And Raw materials Raw materials Α-PROTEIN-->Casein-->Gelatin-->Soy bean Isoflavone Isoflavone 10-40%-->Bone glue Preparation Products (R)-(-)-3-Pyrrolidinol hydrochloride-->N-Boc-cis-4-Hydroxy-L-proline methyl ester-->(2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine-->tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride-->BOC-4-OXO-PRO-OME-->Fmoc-L-hydroxyproline-->3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid-->1-Boc-2-hydroxyMethyl-4-M...-->2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)--->BETONICINE-->TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE-->N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER-->1-BENZYLPYRROLE-->1-PHENYLPYRROLE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-Hydroxyproline Basic information Product Name: L-Hydroxyproline Synonyms: H-HYP-OH;H-HYP-OH (TRANS);H-L-HYDROXYPROLINE;H-L-HYP-OH;H-TRANS-HYP-OH;HYDROXYPROLINE;HYDROXY-L-PROLINE;HYDROXY-L-PROLINE, TRANS-4- CAS: 51-35-4 MF: C5H9NO3 MW: 131.13 EINECS: 200-091-9 Product Categories: Amino Acids;Pyrrole&Pyrrolidine&Pyrroline;Hydroxyproline [Hyp];Unusual Amino Acids;Biochemistry;Biological-modified Amino Acids;Nitrogen cyclic compounds;PHARMACEUTICALS;Amino Acids;L-Amino Acids;Amino Acids & Derivatives;Chiral Reagents;Heterocycles Mol File: 51-35-4.mol   L-Hydroxyproline Chemical Properties Melting point  273 °C (dec.)(lit.) alpha  -75.5 º (c=5, H2O) Boiling point  242.42°C (rough estimate) density  1.3121 (rough estimate) vapor density  4.5 (vs air) refractive index  -75.5 ° (C=4, H2O) storage temp.  Store below +30°C. solubility  H2O: 50 mg/mL form  Crystals or Crystalline Powder pka 1.82, 9.66(at 25℃) color  White PH 5.5-6.5 (50g/l, H2O, 20℃) Odor Odorless optical activity [α]25/D 75.6°, c = 1 in H2O Water Solubility  357.8 g/L (20 º C) Merck  14,4840 BRN  471933 InChIKey PMMYEEVYMWASQN-DMTCNVIQSA-N CAS DataBase Reference 51-35-4(CAS DataBase Reference) NIST Chemistry Reference Hydroxyproline(51-35-4) EPA Substance Registry System trans-4-Hydroxy-L-proline (51-35-4)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  24/25-36/37/39-27-26 WGK Germany  3 RTECS  TW3586500 Hazard Note  Irritant TSCA  Yes HazardClass  IRRITANT HS Code  29339990 MSDS Information Provider Language (2S,4R)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid English SigmaAldrich English ACROS English ALFA English   L-Hydroxyproline Usage And Synthesis Description A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys. Chemical Properties White crystalline powder Uses A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline. Uses A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins. Uses hydroxyproline is a skin-conditioning amino acid. It is a component of collagen. Definition ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration. Production Methods In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix. Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients. Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines. General Description Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards Biochem/physiol Actions Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues. Purification Methods Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]   L-Hydroxyproline Preparation Products And Raw materials Raw materials Α-PROTEIN-->Casein-->Gelatin-->Soy bean Isoflavone Isoflavone 10-40%-->Bone glue Preparation Products (R)-(-)-3-Pyrrolidinol hydrochloride-->N-Boc-cis-4-Hydroxy-L-proline methyl ester-->(2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine-->tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride-->BOC-4-OXO-PRO-OME-->Fmoc-L-hydroxyproline-->3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid-->1-Boc-2-hydroxyMethyl-4-M...-->2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)--->BETONICINE-->TRANS-4-HYDROXY-1-(4-NITROBENZYLOXYCARBONYL)-L-PROLINE-->N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER-->1-BENZYLPYRROLE-->1-PHENYLPYRROLE