China Largest Manufacturer factory Supply Cycloleucine CAS 52-52-8 CAS NO.52-52-8

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Cycloleucine Basic information Product Name: Cycloleucine Synonyms: RARECHEM AK HD C019;TIMTEC-BB SBB004230;1-amino-cyclopentanecarboxylicaci;Amino-1-cyclopentanecarboxylic acid;CB 1639;cb1639;Cycloleucin;Cyclopentanecarboxylic Acid, 1-amino-, L- CAS: 52-52-8 MF: C6H11NO2 MW: 129.16 EINECS: 200-144-6 Product Categories: Amino Acids;pharmacetical;Amino Acids;Amino Acids & Derivatives;Cycloalkanes;Pyridines;amino Mol File: 52-52-8.mol   Cycloleucine Chemical Properties Melting point  320 °C (dec.) (lit.) Boiling point  239.22°C (rough estimate) density  1.1426 (rough estimate) refractive index  1.4827 (estimate) storage temp.  Keep in dark place,Inert atmosphere,Room temperature pka 2.38±0.20(Predicted) form  Crystalline Flakes or Powder color  White to beige Water Solubility  5 g/100 mL Merck  14,2734 BRN  636626 CAS DataBase Reference 52-52-8(CAS DataBase Reference) NIST Chemistry Reference Cyclopentanecarboxylic acid, 1-amino-(52-52-8) EPA Substance Registry System Cyclopentanecarboxylic acid, 1-amino- (52-52-8)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22 Safety Statements  22-24/25 RIDADR  UN 2811 6.1/PG 3 WGK Germany  3 RTECS  GY2625000 TSCA  Yes HazardClass  6.1 PackingGroup  III HS Code  29224999 Hazardous Substances Data 52-52-8(Hazardous Substances Data) Toxicity LD50 oral in rat: 290mg/kg MSDS Information Provider Language Cycloleucine English ACROS English SigmaAldrich English ALFA English   Cycloleucine Usage And Synthesis Chemical Properties WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER Uses NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist Uses Cycloleucine can be used as a building block to synthesize: Phosphonylmethylaminocyclopentane-1-carboxylic acid by reacting with paraformaldehyde and diethylphosphite via Kabachnik-Field′s reaction. Benzo[b]thiophene-2-carboxylic acid {1-[1-(R)-(3-morpholin-4-ylpropylcarbamoyl)-2-phenylethylcarbamoyl]cyclopentyl}-amide, (MEN14268) as potential tachykinin NK2 receptor antagonist. Uses Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies Definition ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. General Description Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis. Purification Methods Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]   Cycloleucine Preparation Products And Raw materials Preparation Products Methyl 1-amino-1-cyclopentanecarboxylate-->Methyl 1-amino-1-cyclopentanecarboxylate h

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Cycloleucine Basic information Product Name: Cycloleucine Synonyms: RARECHEM AK HD C019;TIMTEC-BB SBB004230;1-amino-cyclopentanecarboxylicaci;Amino-1-cyclopentanecarboxylic acid;CB 1639;cb1639;Cycloleucin;Cyclopentanecarboxylic Acid, 1-amino-, L- CAS: 52-52-8 MF: C6H11NO2 MW: 129.16 EINECS: 200-144-6 Product Categories: Amino Acids;pharmacetical;Amino Acids;Amino Acids & Derivatives;Cycloalkanes;Pyridines;amino Mol File: 52-52-8.mol   Cycloleucine Chemical Properties Melting point  320 °C (dec.) (lit.) Boiling point  239.22°C (rough estimate) density  1.1426 (rough estimate) refractive index  1.4827 (estimate) storage temp.  Keep in dark place,Inert atmosphere,Room temperature pka 2.38±0.20(Predicted) form  Crystalline Flakes or Powder color  White to beige Water Solubility  5 g/100 mL Merck  14,2734 BRN  636626 CAS DataBase Reference 52-52-8(CAS DataBase Reference) NIST Chemistry Reference Cyclopentanecarboxylic acid, 1-amino-(52-52-8) EPA Substance Registry System Cyclopentanecarboxylic acid, 1-amino- (52-52-8)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22 Safety Statements  22-24/25 RIDADR  UN 2811 6.1/PG 3 WGK Germany  3 RTECS  GY2625000 TSCA  Yes HazardClass  6.1 PackingGroup  III HS Code  29224999 Hazardous Substances Data 52-52-8(Hazardous Substances Data) Toxicity LD50 oral in rat: 290mg/kg MSDS Information Provider Language Cycloleucine English ACROS English SigmaAldrich English ALFA English   Cycloleucine Usage And Synthesis Chemical Properties WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER Uses NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist Uses Cycloleucine can be used as a building block to synthesize: Phosphonylmethylaminocyclopentane-1-carboxylic acid by reacting with paraformaldehyde and diethylphosphite via Kabachnik-Field′s reaction. Benzo[b]thiophene-2-carboxylic acid {1-[1-(R)-(3-morpholin-4-ylpropylcarbamoyl)-2-phenylethylcarbamoyl]cyclopentyl}-amide, (MEN14268) as potential tachykinin NK2 receptor antagonist. Uses Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies Definition ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. General Description Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis. Purification Methods Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]   Cycloleucine Preparation Products And Raw materials Preparation Products Methyl 1-amino-1-cyclopentanecarboxylate-->Methyl 1-amino-1-cyclopentanecarboxylate h