China Largest Factory Manufacturer sales N-Hydroxyphthalimide CAS 524-38-9 CAS NO.524-38-9

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N-Hydroxyphthalimide Basic information Product Name: N-Hydroxyphthalimide Synonyms: TIMTEC-BB SBB009098;N-HYDROXY-PHTALIMIDE;N-HYDROXYPHTHALIMIDE;2-hydroxy-1h-isoindole-3(2h)-dione;N-Hydroxyphthalimide, remainder 10-15% moisture;N-Hydroxyphehtalimide;N-HYDROXYMETHYL-3-METHYLOXETANE;N-Hydroxyphthalimide(Nop) CAS: 524-38-9 MF: C8H5NO3 MW: 163.13 EINECS: 208-358-1 Product Categories: Active Esters/Additives;Active Esters/AdditivesSynthetic Reagents;Biochemistry;Carbon Radical Producing Catalysts (Environmentally-friendly Oxidation);Coupling;Peptide Synthesis;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Environmentally-friendly Oxidation;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Peptide Synthesis;Synthetic Organic Chemistry;API;intermediates Mol File: 524-38-9.mol   N-Hydroxyphthalimide Chemical Properties Melting point  233 °C (dec.) (lit.) Boiling point  290.19°C (rough estimate) density  1.64 g/cm3 refractive index  1.5510 (estimate) storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  DMSO (Slightly), Methanol (Slightly) pka 6.10±0.20(Predicted) form  Powder color  Yellow Water Solubility  Slightly soluble in water. Merck  14,4838 BRN  131208 InChIKey CFMZSMGAMPBRBE-UHFFFAOYSA-N CAS DataBase Reference 524-38-9(CAS DataBase Reference) EPA Substance Registry System 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  TI5200000 TSCA  Yes HazardClass  IRRITANT HS Code  29251995 MSDS Information Provider Language N-Hydroxyphthalimide English ACROS English SigmaAldrich English ALFA English   N-Hydroxyphthalimide Usage And Synthesis Chemical Properties N-Hydroxyphthalimide is yellow moist powder Uses N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product. Uses Catalyst for oxidation reactions. Uses Aerobic oxidation of various alcohols has been accomplished by using a new catalytic system, N-hydroxyphthalimide (NHPI) combined with Co (acac). A practical catalytic method to convert alkylbenzenes into the corresponding carboxylic acids under atmospheric dioxygen at ambient temperature using a combined catalytic system consisting of N-hydroxyphthalimide (NHPI) and Co (OAc) 2 was developed. Novel catalysis by N-hydroxyphthalimide in the oxidation of organic substrates by molecular oxygen was described. Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide. Purely organic and catalytic systems of anthraquinones and N-hydroxyphthalimide efficiently promote oxygenation of hydrocarbons with dioxygen under mild conditions. Hydroxylation of polycyclic alkanes with molecular oxygen catalyzed by N-hydroxyphthalimide (NHPI) combined with was transition metal salts. Application N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines. Synthesis Reference(s) Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0 Purification Methods N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]   N-Hydroxyphthalimide Preparation Products And Raw materials Raw materials 2H-Isoindole-2-carboxylic acid, 1,3-dihydro-1,3-dioxo-, 1,1-dimethylethyl ester-->1,3-dioxoisoindolin-2-yl acetate-->Benzenebutanoic acid, α-methylene-, ethyl ester-->NA-->2,4-DIPHENYL-1-BUTENE-D5-->FMOC-L-Phenylalanine-->2-phenylmethoxyisoindole-1,3-dione-->2,4-Diphenyl-4-methyl-1-pentene-->Phthaloyl dichloride Preparation Products O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE-->1,3-Adamantanediol-->TERT-BUTYL N-(BENZYLOXY)CARBAMATE-->1-Adamantanol-->synthetic tanning agent HV-->synthetic tanning agent No.742-->5-Hydroxy-1,4-naphthalenedione-->1H-Isoindol-1-one, 3-hydroxy-

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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N-Hydroxyphthalimide Basic information Product Name: N-Hydroxyphthalimide Synonyms: TIMTEC-BB SBB009098;N-HYDROXY-PHTALIMIDE;N-HYDROXYPHTHALIMIDE;2-hydroxy-1h-isoindole-3(2h)-dione;N-Hydroxyphthalimide, remainder 10-15% moisture;N-Hydroxyphehtalimide;N-HYDROXYMETHYL-3-METHYLOXETANE;N-Hydroxyphthalimide(Nop) CAS: 524-38-9 MF: C8H5NO3 MW: 163.13 EINECS: 208-358-1 Product Categories: Active Esters/Additives;Active Esters/AdditivesSynthetic Reagents;Biochemistry;Carbon Radical Producing Catalysts (Environmentally-friendly Oxidation);Coupling;Peptide Synthesis;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Environmentally-friendly Oxidation;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Peptide Synthesis;Synthetic Organic Chemistry;API;intermediates Mol File: 524-38-9.mol   N-Hydroxyphthalimide Chemical Properties Melting point  233 °C (dec.) (lit.) Boiling point  290.19°C (rough estimate) density  1.64 g/cm3 refractive index  1.5510 (estimate) storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  DMSO (Slightly), Methanol (Slightly) pka 6.10±0.20(Predicted) form  Powder color  Yellow Water Solubility  Slightly soluble in water. Merck  14,4838 BRN  131208 InChIKey CFMZSMGAMPBRBE-UHFFFAOYSA-N CAS DataBase Reference 524-38-9(CAS DataBase Reference) EPA Substance Registry System 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  TI5200000 TSCA  Yes HazardClass  IRRITANT HS Code  29251995 MSDS Information Provider Language N-Hydroxyphthalimide English ACROS English SigmaAldrich English ALFA English   N-Hydroxyphthalimide Usage And Synthesis Chemical Properties N-Hydroxyphthalimide is yellow moist powder Uses N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product. Uses Catalyst for oxidation reactions. Uses Aerobic oxidation of various alcohols has been accomplished by using a new catalytic system, N-hydroxyphthalimide (NHPI) combined with Co (acac). A practical catalytic method to convert alkylbenzenes into the corresponding carboxylic acids under atmospheric dioxygen at ambient temperature using a combined catalytic system consisting of N-hydroxyphthalimide (NHPI) and Co (OAc) 2 was developed. Novel catalysis by N-hydroxyphthalimide in the oxidation of organic substrates by molecular oxygen was described. Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide. Purely organic and catalytic systems of anthraquinones and N-hydroxyphthalimide efficiently promote oxygenation of hydrocarbons with dioxygen under mild conditions. Hydroxylation of polycyclic alkanes with molecular oxygen catalyzed by N-hydroxyphthalimide (NHPI) combined with was transition metal salts. Application N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines. Synthesis Reference(s) Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0 Purification Methods N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]   N-Hydroxyphthalimide Preparation Products And Raw materials Raw materials 2H-Isoindole-2-carboxylic acid, 1,3-dihydro-1,3-dioxo-, 1,1-dimethylethyl ester-->1,3-dioxoisoindolin-2-yl acetate-->Benzenebutanoic acid, α-methylene-, ethyl ester-->NA-->2,4-DIPHENYL-1-BUTENE-D5-->FMOC-L-Phenylalanine-->2-phenylmethoxyisoindole-1,3-dione-->2,4-Diphenyl-4-methyl-1-pentene-->Phthaloyl dichloride Preparation Products O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE-->1,3-Adamantanediol-->TERT-BUTYL N-(BENZYLOXY)CARBAMATE-->1-Adamantanol-->synthetic tanning agent HV-->synthetic tanning agent No.742-->5-Hydroxy-1,4-naphthalenedione-->1H-Isoindol-1-one, 3-hydroxy-