China Largest Manufacturer factory Supply BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE(NADP) CAS 53-59-8 CAS NO.53-59-8

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Triphosphopyridine nucleotide Basic information Product Name: Triphosphopyridine nucleotide Synonyms: nadide phosphate;B-NICOTINAMIDE ADENINE DINUCLEOTIDE*PHOS PHATE FREE;β-nicotinamide adenine dinucleotide phosphate hydrate;B-NICOTINAMIDEADENINEDINUCLEOTIDEPHOSPHATE,HYDRATE;[(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-[[[[(2R,3S,4R,5R)-5-(5-carbamoylpyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid;TPN;TPNH;TRIPHOSPHOPYRIDINE NUCLEOTIDE CAS: 53-59-8 MF: C21H28N7O17P3 MW: 743.41 EINECS: 200-178-1 Product Categories:   Mol File: 53-59-8.mol   Triphosphopyridine nucleotide Chemical Properties storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C solubility  H2O: 50 mg/mL, clear, slightly yellow pka pKa1 3.9; pKa2 6.1(at 25℃) λmax 260nm(lit.) Merck  14,6348 EPA Substance Registry System Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-59-8)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  3 RTECS  UU3440000 F  10-21 MSDS Information Provider Language SigmaAldrich English   Triphosphopyridine nucleotide Usage And Synthesis Uses β-Nicotinamide adenine dinucleotide phosphate hydrate is suitable for use in: the measurement of Glucose-6-phosphate dehydrogenase activity the Cytochrome P450 3A4 assay as a part of NADPH-regenerating system the Cytochrome P450 2D6 assay as a part of NADPH-regenerating system the determination of Glucose-6-phosphate content Definition The oxidized form of nicotinamide adenine dinucleotide phosphate (NADP) that receives electrons from photosystem I during photosynthesis. It exists as an anion under normal physiologic conditions. Biological Functions Triphosphopyridine nucleotide (NADP) serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). Biochem/physiol Actions β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). Purification Methods Purify NMN by passage through a column of Dowex-1 (Clform) and washing with H2O until no absorbance is observed at 260 nm. The tubes containing NMN are pooled, adjusted to pH 5.5-6 and evaporated in vacuo to a small volume. This is adjusted to pH 3 with dilute HNO3 in an ice-bath and treated with 20volumes of Me2CO at 0-5o. The heavy white precipitate is collected by centrifugation at 0o. It is best stored wet and frozen or it can be dried to give a gummy residue. It has max 266nm ( 4,600) and min 249nm ( 3600) at pH 7.0 (i.e. no absorption at 340nm). It can be estimated by reaction with CNor hydrosulfite which form the 4-adducts (equivalent to NADH) which have UV max 340nm ( 6,200). Thus after reaction, an OD340 of one is obtained from a 0.1612mM solution in a 1cm path cuvette. [Plaut & Plaut Biochemical Preparations 5 56 1957, Maplan & Stolzenbach Methods Enzymol 3 899 1957, Kaplan et al. J Am Chem Soc 77 815 1955, Beilstein 22/2 V 168.]   Triphosphopyridine nucleotide Preparation Products And Raw materials Raw materials AMBERLITE(R) IRC-50-->Trichloroacetic acid-->[(2R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]me thoxyphosphonic acid Preparation Products 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE-->5-amino-2,5-dioxo-pentanoic acid-->25 MG -NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR.

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Triphosphopyridine nucleotide Basic information Product Name: Triphosphopyridine nucleotide Synonyms: nadide phosphate;B-NICOTINAMIDE ADENINE DINUCLEOTIDE*PHOS PHATE FREE;β-nicotinamide adenine dinucleotide phosphate hydrate;B-NICOTINAMIDEADENINEDINUCLEOTIDEPHOSPHATE,HYDRATE;[(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-[[[[(2R,3S,4R,5R)-5-(5-carbamoylpyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid;TPN;TPNH;TRIPHOSPHOPYRIDINE NUCLEOTIDE CAS: 53-59-8 MF: C21H28N7O17P3 MW: 743.41 EINECS: 200-178-1 Product Categories:   Mol File: 53-59-8.mol   Triphosphopyridine nucleotide Chemical Properties storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C solubility  H2O: 50 mg/mL, clear, slightly yellow pka pKa1 3.9; pKa2 6.1(at 25℃) λmax 260nm(lit.) Merck  14,6348 EPA Substance Registry System Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-59-8)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  3 RTECS  UU3440000 F  10-21 MSDS Information Provider Language SigmaAldrich English   Triphosphopyridine nucleotide Usage And Synthesis Uses β-Nicotinamide adenine dinucleotide phosphate hydrate is suitable for use in: the measurement of Glucose-6-phosphate dehydrogenase activity the Cytochrome P450 3A4 assay as a part of NADPH-regenerating system the Cytochrome P450 2D6 assay as a part of NADPH-regenerating system the determination of Glucose-6-phosphate content Definition The oxidized form of nicotinamide adenine dinucleotide phosphate (NADP) that receives electrons from photosystem I during photosynthesis. It exists as an anion under normal physiologic conditions. Biological Functions Triphosphopyridine nucleotide (NADP) serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). Biochem/physiol Actions β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). Purification Methods Purify NMN by passage through a column of Dowex-1 (Clform) and washing with H2O until no absorbance is observed at 260 nm. The tubes containing NMN are pooled, adjusted to pH 5.5-6 and evaporated in vacuo to a small volume. This is adjusted to pH 3 with dilute HNO3 in an ice-bath and treated with 20volumes of Me2CO at 0-5o. The heavy white precipitate is collected by centrifugation at 0o. It is best stored wet and frozen or it can be dried to give a gummy residue. It has max 266nm ( 4,600) and min 249nm ( 3600) at pH 7.0 (i.e. no absorption at 340nm). It can be estimated by reaction with CNor hydrosulfite which form the 4-adducts (equivalent to NADH) which have UV max 340nm ( 6,200). Thus after reaction, an OD340 of one is obtained from a 0.1612mM solution in a 1cm path cuvette. [Plaut & Plaut Biochemical Preparations 5 56 1957, Maplan & Stolzenbach Methods Enzymol 3 899 1957, Kaplan et al. J Am Chem Soc 77 815 1955, Beilstein 22/2 V 168.]   Triphosphopyridine nucleotide Preparation Products And Raw materials Raw materials AMBERLITE(R) IRC-50-->Trichloroacetic acid-->[(2R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]me thoxyphosphonic acid Preparation Products 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE-->5-amino-2,5-dioxo-pentanoic acid-->25 MG -NICOTINAMIDE ADENINE DINUCLEOTIDEPHOSPHATE REDUCED.NA4-SALT AN.GR.