China Biggest Manufacturer supply Pyridoxal phosphate CAS NO.54-47-7

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Pyridoxal phosphate Basic information Product Name: Pyridoxal phosphate Synonyms: PYRIDOXAL-5-PHOSPHORIC ACID;PYRIDOXAL 5'-MONOPHOSPHATE;CODECARBOXYLASE;3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehyd;3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyd;apolonb(sub6);apolonb6;biosechs CAS: 54-47-7 MF: C8H10NO6P MW: 247.14 EINECS: 200-208-3 Product Categories: Aromatics;Heterocycles;Vitamins and derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents Mol File: 54-47-7.mol   Pyridoxal phosphate Chemical Properties Melting point  140-143 °C Boiling point  565.7±60.0 °C(Predicted) density  1.638±0.06 g/cm3(Predicted) storage temp.  Inert atmosphere,Store in freezer, under -20°C form  powder pka 1.56±0.10(Predicted) CAS DataBase Reference 54-47-7(CAS DataBase Reference) EPA Substance Registry System 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]- (54-47-7)   Safety Information Safety Statements  22-24/25 WGK Germany  3 F  8-10-23 HS Code  29362500 MSDS Information Provider Language 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde English SigmaAldrich English   Pyridoxal phosphate Usage And Synthesis Chemical Properties Light yellow crystalline Uses Vitamin (enzyme co-factor). Definition The coenzyme of amino acid metabolism that also is the active group of various decarboxylases and other types of enzymes. It is closely related to pyridoxine. Synthesis Reference(s) Journal of the American Chemical Society, 73, p. 4693, 1951 DOI: 10.1021/ja01154a062 Purification Methods PLP has been purified by dissolving 2g in H2O (10-15mL, in a dialysis bag a third full) and dialysing with gentle stirring against 1L of H2O (+ two drops of toluene) for 15hours in a cold room. The dialysate is evaporated to 80-100mL, then lyophilised. Lemon yellow microscopic needles of the monohydrate remain when all the ice crystals have been removed. The purity is checked by paper chromatography (in EtOH or n-PrOH/NH3) and the spot(s) visualised under UV light after reaction with a spray of p-phenylene diamine, NH3 and molybdate. Solutions stored in a freezer are 2-3% hydrolysed in 3weeks. At 25o, only 4-6% hydrolysis occurs even in N NaOH or HCl, and 2% is hydrolysed at 37o in 1day-but is complete at 100o in 4hours. It is best stored as a dry solid at -20o. In aqueous acid the solution is colourless but is yellow in alkaline solutions. It has UV max at 305nm ( 1100) and 380nm ( 6550) in 0.1 N NaOH; 330nm ( 2450) and 388nm ( 4,900) in 0.05M phosphate buffer pH 7.0 and 295nm ( 6700) in 0.1N HCl. [Peterson et al. Biochemical Preparations 3 34, 119 1953.] The oxime decomposes at 229-230o and is practically insoluble in H2O, EtOH and Et2O. The O-methyloxime decomposes at 212-213o. [Heyl et al. J Am Chem Soc 73 3430 1951.] It has also been purified by column chromatography through Amberlite IRC-50 (H+) [Peterson & Sober J Am Chem Soc 76 169 1954]. [Beilstein 21/13 V 46.]   Pyridoxal phosphate Preparation Products And Raw materials Raw materials Manganese dioxide-->Phosphorus pentoxide-->SULPHOSUCCINIC ACID ESTER-->Pyridoxine-->Pyridoxamine dihydrochloride-->3-Pyridinemethanol, 4-[[(4-ethoxyphenyl)imino]methyl]-5-hydroxy-6-methyl-, α-(dihydrogen phosphate) (9CI)-->PYRIDOXAMINE-5'-PHOSPHATE-->5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate-->Pyridoxal hydrochloride-->2-Aminoisobutyric Acid-->Pyridoxine hydrochloride-->DL-Alanine Preparation Products 4-Deoxypyridoxine hydrochloride-->Propanedioic acid, aminomethyl- (9CI)-->DL-O-Phosphoserine-->O-PHOSPHORYLETHANOLAMINE

                                Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Pyridoxal phosphate Basic information Product Name: Pyridoxal phosphate Synonyms: PYRIDOXAL-5-PHOSPHORIC ACID;PYRIDOXAL 5'-MONOPHOSPHATE;CODECARBOXYLASE;3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehyd;3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyd;apolonb(sub6);apolonb6;biosechs CAS: 54-47-7 MF: C8H10NO6P MW: 247.14 EINECS: 200-208-3 Product Categories: Aromatics;Heterocycles;Vitamins and derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents Mol File: 54-47-7.mol   Pyridoxal phosphate Chemical Properties Melting point  140-143 °C Boiling point  565.7±60.0 °C(Predicted) density  1.638±0.06 g/cm3(Predicted) storage temp.  Inert atmosphere,Store in freezer, under -20°C form  powder pka 1.56±0.10(Predicted) CAS DataBase Reference 54-47-7(CAS DataBase Reference) EPA Substance Registry System 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]- (54-47-7)   Safety Information Safety Statements  22-24/25 WGK Germany  3 F  8-10-23 HS Code  29362500 MSDS Information Provider Language 3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde English SigmaAldrich English   Pyridoxal phosphate Usage And Synthesis Chemical Properties Light yellow crystalline Uses Vitamin (enzyme co-factor). Definition The coenzyme of amino acid metabolism that also is the active group of various decarboxylases and other types of enzymes. It is closely related to pyridoxine. Synthesis Reference(s) Journal of the American Chemical Society, 73, p. 4693, 1951 DOI: 10.1021/ja01154a062 Purification Methods PLP has been purified by dissolving 2g in H2O (10-15mL, in a dialysis bag a third full) and dialysing with gentle stirring against 1L of H2O (+ two drops of toluene) for 15hours in a cold room. The dialysate is evaporated to 80-100mL, then lyophilised. Lemon yellow microscopic needles of the monohydrate remain when all the ice crystals have been removed. The purity is checked by paper chromatography (in EtOH or n-PrOH/NH3) and the spot(s) visualised under UV light after reaction with a spray of p-phenylene diamine, NH3 and molybdate. Solutions stored in a freezer are 2-3% hydrolysed in 3weeks. At 25o, only 4-6% hydrolysis occurs even in N NaOH or HCl, and 2% is hydrolysed at 37o in 1day-but is complete at 100o in 4hours. It is best stored as a dry solid at -20o. In aqueous acid the solution is colourless but is yellow in alkaline solutions. It has UV max at 305nm ( 1100) and 380nm ( 6550) in 0.1 N NaOH; 330nm ( 2450) and 388nm ( 4,900) in 0.05M phosphate buffer pH 7.0 and 295nm ( 6700) in 0.1N HCl. [Peterson et al. Biochemical Preparations 3 34, 119 1953.] The oxime decomposes at 229-230o and is practically insoluble in H2O, EtOH and Et2O. The O-methyloxime decomposes at 212-213o. [Heyl et al. J Am Chem Soc 73 3430 1951.] It has also been purified by column chromatography through Amberlite IRC-50 (H+) [Peterson & Sober J Am Chem Soc 76 169 1954]. [Beilstein 21/13 V 46.]   Pyridoxal phosphate Preparation Products And Raw materials Raw materials Manganese dioxide-->Phosphorus pentoxide-->SULPHOSUCCINIC ACID ESTER-->Pyridoxine-->Pyridoxamine dihydrochloride-->3-Pyridinemethanol, 4-[[(4-ethoxyphenyl)imino]methyl]-5-hydroxy-6-methyl-, α-(dihydrogen phosphate) (9CI)-->PYRIDOXAMINE-5'-PHOSPHATE-->5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate-->Pyridoxal hydrochloride-->2-Aminoisobutyric Acid-->Pyridoxine hydrochloride-->DL-Alanine Preparation Products 4-Deoxypyridoxine hydrochloride-->Propanedioic acid, aminomethyl- (9CI)-->DL-O-Phosphoserine-->O-PHOSPHORYLETHANOLAMINE