Manufacturer supply Raspberry ketone CAS NO.5471-51-2

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Raspberry Ketone Basic information Chemical properties Uses Production method Product Name: Raspberry Ketone Synonyms: 4-(4-Hydroxyphenyl)-2-butanone 5471-51-2;Natural Raspberry Ketone;Dobutamine EP Impurity B;Dobutamine Hydrochloride Impurit Ⅰ:4-(4-Hydroxyphenyl)-2-butanone;4-p-Hydroxylphenyl)-2-butone;Raspberry keton;RASPBERRY KETONE;RASBERRY KETONE CAS: 5471-51-2 MF: C10H12O2 MW: 164.2 EINECS: 226-806-4 Product Categories: Aromatic Ketones (substituted);Food and Feed Additive;Aromatics;Herb extract;5471-51-2 Mol File: 5471-51-2.mol   Raspberry Ketone Chemical Properties Melting point  81-85 °C (lit.) Boiling point  200°C density  1.0326 (rough estimate) FEMA  2588 | 4-(P-HYDROXYPHENYL)-2-BUTANONE refractive index  1.5250 (estimate) storage temp.  under inert gas (argon) solubility  95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan pka 9.99±0.15(Predicted) form  Liquid color  Clear colorless Water Solubility  Insoluble in water. JECFA Number 728 BRN  776080 InChIKey NJGBTKGETPDVIK-UHFFFAOYSA-N CAS DataBase Reference 5471-51-2(CAS DataBase Reference) NIST Chemistry Reference 2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2) EPA Substance Registry System 2-Butanone, 4-(4-hydroxyphenyl)- (5471-51-2)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22 Safety Statements  26-36/37/39-36 WGK Germany  2 RTECS  EL8925000 Hazard Note  Irritant TSCA  Yes HS Code  29145011 Hazardous Substances Data 5471-51-2(Hazardous Substances Data) MSDS Information Provider Language Frambinone English SigmaAldrich English ACROS English ALFA English   Raspberry Ketone Usage And Synthesis Chemical properties It appears as white needle crystal or granular solid, exhibiting raspberry aroma and fruit aroma. The melting point temperature is 82~83 °C. It is insoluble in water and oil, being soluble in alcohol, ether and volatile oil. The natural products exist in raspberry (raspberry) and so on. Uses 1. Raspberry Ketone is used in the preparation of food spices with sweetening effect, can also be used for cosmetics and soap flavor. 2. Raspberry Ketone is widely used in strawberry, raspberry, pineapple, peaches and other food flavors, usually used as a fixing agent in the fruity flavor. In daily flavor, it can be used in formulations such as jasmine, gardenia flowers and tuberose. As a modifier, it can be used in jasmine, gardenia, tuberose and other fragrant daily flavor. In food flavors, it is mostly used for strawberries, pineapple, peaches, plums, mayberry and other fragrance. In medicine, it is mostly used as intermediates. Production method 3.5mol 15% sodium hydroxide is first added to the reactor, and 2 mol of acetone and 1mol of p-hydroxybenzaldehyde are added dropwise under stirring. The temperature is controlled between 20 and 30 DEG C, and the stirring reaction is continued for 20 hours. The solid sodium salt of 4-p-hydroxyphenylbutene-3-ketone-2 was obtained after filtering, further dissolved in water, and then acidified with hydrochloric acid to precipitate 4-p-hydroxyphenylbutene-3-ketone-2, further filter and dry for further application. The autoclave was supplied with 100 g of the intermediate and 5 g of the nickel catalyst, and the atmosphere was replaced with hydrogen. The mixture was heated to 120-140 °C and reacted at a pressure of 0.98 MPa for 1.5 h. After cooling, the catalyst was filtered off, the raspberry ketone content was 89% and the hydrogenation yield was 92%. The crude product above is subject to vacuum distillation once with further recrystallization of 1-2 times getting white crystals with the melting point of 82 ° C. Phenol route 94g phenol and 85% phosphoric acid mixed catalyst were added into the reactor, 70g methyl vinyl ketone was added dropwise in 40min, the temperature was maintained at 15-20 ℃, and the reaction was stirred for 4h. After completion of the reaction, the reaction mixture was washed with water until neutral, and 63 g of phenol was distilled off under reduced pressure to obtain 25 g of a product having a melting point of 81.5 to 82.5 ° C and a yield of 80%. It is obtained through the condensation between hydroxybenzaldehyde and acetone and further hydrogenation. It is obtained through the condensation between the ketone acid and phenol. Description 4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves odor. May be prepared by catalytic hydrogenation of phydroxy-benzylidene acetone in the presence of platinum black in ether or methanol or in the presence of palladium absorbed on charcoal. Chemical Properties 4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves–type odor. Chemical Properties 4-(4-Hydroxyphenyl)-2-butanone is a highly characteristic component of raspberry aroma. It forms colorless crystals (mp 82–83°C) with a sweet, fruity odor strongly reminiscent of raspberries. Raspberry ketone is prepared by alkali-catalyzed condensation of the alkali salt of 4-hydroxybenzaldehyde and acetone, followed by selective hydrogenation of the double bond in the resulting 4-hydroxybenzalacetone. Other syntheses start from phenol, which is converted into 4-(4-hydroxyphenyl)-2-butanone with methyl vinyl ketone or with 4-hydroxy-2-butanone. Chemical Properties white to slightly yellow powder or needles Occurrence Reported found European cranberry, raspberry, blackberry, loganberry and sea buckthorn (Hippophae rhamnoides L.). Uses 4-(4-Hydroxyphenyl)-2-butanone is used in perfumery, in cosmetics, and as a food additive to impart a fruity odor. Uses The primary aroma compound of red raspberries, used in perfume compositions, shampoos, cosmetics and as a food additive. Also an impurity in the synthesis of Dobutamine (D494445). Uses Intermediates of Liquid Crystals Definition ChEBI: A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics. Taste threshold values Taste characteristics at 40 ppm: fruity, jamy, berry, raspberry, and blueberry with seedy, cotton candy nuances Synthesis Reference(s) The Journal of Organic Chemistry, 41, p. 1206, 1976 DOI: 10.1021/jo00869a026 Synthetic Communications, 19, p. 1109, 1989 DOI: 10.1080/00397918908051034 Safety Profile Poison by intraperitoneal route. Moderately toxic by ingestion. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.   Raspberry Ketone Preparation Products And Raw materials Raw materials Ethanol-->Acetone-->p-Hydroxybenzaldehyde-->Methyl vinyl ketone-->4-Phenyl-1-butene-->4,4'-Carbonyldiphthalic acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Raspberry Ketone Basic information Chemical properties Uses Production method Product Name: Raspberry Ketone Synonyms: 4-(4-Hydroxyphenyl)-2-butanone 5471-51-2;Natural Raspberry Ketone;Dobutamine EP Impurity B;Dobutamine Hydrochloride Impurit Ⅰ:4-(4-Hydroxyphenyl)-2-butanone;4-p-Hydroxylphenyl)-2-butone;Raspberry keton;RASPBERRY KETONE;RASBERRY KETONE CAS: 5471-51-2 MF: C10H12O2 MW: 164.2 EINECS: 226-806-4 Product Categories: Aromatic Ketones (substituted);Food and Feed Additive;Aromatics;Herb extract;5471-51-2 Mol File: 5471-51-2.mol   Raspberry Ketone Chemical Properties Melting point  81-85 °C (lit.) Boiling point  200°C density  1.0326 (rough estimate) FEMA  2588 | 4-(P-HYDROXYPHENYL)-2-BUTANONE refractive index  1.5250 (estimate) storage temp.  under inert gas (argon) solubility  95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan pka 9.99±0.15(Predicted) form  Liquid color  Clear colorless Water Solubility  Insoluble in water. JECFA Number 728 BRN  776080 InChIKey NJGBTKGETPDVIK-UHFFFAOYSA-N CAS DataBase Reference 5471-51-2(CAS DataBase Reference) NIST Chemistry Reference 2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2) EPA Substance Registry System 2-Butanone, 4-(4-hydroxyphenyl)- (5471-51-2)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22 Safety Statements  26-36/37/39-36 WGK Germany  2 RTECS  EL8925000 Hazard Note  Irritant TSCA  Yes HS Code  29145011 Hazardous Substances Data 5471-51-2(Hazardous Substances Data) MSDS Information Provider Language Frambinone English SigmaAldrich English ACROS English ALFA English   Raspberry Ketone Usage And Synthesis Chemical properties It appears as white needle crystal or granular solid, exhibiting raspberry aroma and fruit aroma. The melting point temperature is 82~83 °C. It is insoluble in water and oil, being soluble in alcohol, ether and volatile oil. The natural products exist in raspberry (raspberry) and so on. Uses 1. Raspberry Ketone is used in the preparation of food spices with sweetening effect, can also be used for cosmetics and soap flavor. 2. Raspberry Ketone is widely used in strawberry, raspberry, pineapple, peaches and other food flavors, usually used as a fixing agent in the fruity flavor. In daily flavor, it can be used in formulations such as jasmine, gardenia flowers and tuberose. As a modifier, it can be used in jasmine, gardenia, tuberose and other fragrant daily flavor. In food flavors, it is mostly used for strawberries, pineapple, peaches, plums, mayberry and other fragrance. In medicine, it is mostly used as intermediates. Production method 3.5mol 15% sodium hydroxide is first added to the reactor, and 2 mol of acetone and 1mol of p-hydroxybenzaldehyde are added dropwise under stirring. The temperature is controlled between 20 and 30 DEG C, and the stirring reaction is continued for 20 hours. The solid sodium salt of 4-p-hydroxyphenylbutene-3-ketone-2 was obtained after filtering, further dissolved in water, and then acidified with hydrochloric acid to precipitate 4-p-hydroxyphenylbutene-3-ketone-2, further filter and dry for further application. The autoclave was supplied with 100 g of the intermediate and 5 g of the nickel catalyst, and the atmosphere was replaced with hydrogen. The mixture was heated to 120-140 °C and reacted at a pressure of 0.98 MPa for 1.5 h. After cooling, the catalyst was filtered off, the raspberry ketone content was 89% and the hydrogenation yield was 92%. The crude product above is subject to vacuum distillation once with further recrystallization of 1-2 times getting white crystals with the melting point of 82 ° C. Phenol route 94g phenol and 85% phosphoric acid mixed catalyst were added into the reactor, 70g methyl vinyl ketone was added dropwise in 40min, the temperature was maintained at 15-20 ℃, and the reaction was stirred for 4h. After completion of the reaction, the reaction mixture was washed with water until neutral, and 63 g of phenol was distilled off under reduced pressure to obtain 25 g of a product having a melting point of 81.5 to 82.5 ° C and a yield of 80%. It is obtained through the condensation between hydroxybenzaldehyde and acetone and further hydrogenation. It is obtained through the condensation between the ketone acid and phenol. Description 4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves odor. May be prepared by catalytic hydrogenation of phydroxy-benzylidene acetone in the presence of platinum black in ether or methanol or in the presence of palladium absorbed on charcoal. Chemical Properties 4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves–type odor. Chemical Properties 4-(4-Hydroxyphenyl)-2-butanone is a highly characteristic component of raspberry aroma. It forms colorless crystals (mp 82–83°C) with a sweet, fruity odor strongly reminiscent of raspberries. Raspberry ketone is prepared by alkali-catalyzed condensation of the alkali salt of 4-hydroxybenzaldehyde and acetone, followed by selective hydrogenation of the double bond in the resulting 4-hydroxybenzalacetone. Other syntheses start from phenol, which is converted into 4-(4-hydroxyphenyl)-2-butanone with methyl vinyl ketone or with 4-hydroxy-2-butanone. Chemical Properties white to slightly yellow powder or needles Occurrence Reported found European cranberry, raspberry, blackberry, loganberry and sea buckthorn (Hippophae rhamnoides L.). Uses 4-(4-Hydroxyphenyl)-2-butanone is used in perfumery, in cosmetics, and as a food additive to impart a fruity odor. Uses The primary aroma compound of red raspberries, used in perfume compositions, shampoos, cosmetics and as a food additive. Also an impurity in the synthesis of Dobutamine (D494445). Uses Intermediates of Liquid Crystals Definition ChEBI: A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics. Taste threshold values Taste characteristics at 40 ppm: fruity, jamy, berry, raspberry, and blueberry with seedy, cotton candy nuances Synthesis Reference(s) The Journal of Organic Chemistry, 41, p. 1206, 1976 DOI: 10.1021/jo00869a026 Synthetic Communications, 19, p. 1109, 1989 DOI: 10.1080/00397918908051034 Safety Profile Poison by intraperitoneal route. Moderately toxic by ingestion. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.   Raspberry Ketone Preparation Products And Raw materials Raw materials Ethanol-->Acetone-->p-Hydroxybenzaldehyde-->Methyl vinyl ketone-->4-Phenyl-1-butene-->4,4'-Carbonyldiphthalic acid