PRODUCT DETAILS
| 4-HYDROXYISOLEUCINE Basic information |
| Product Name: |
4-HYDROXYISOLEUCINE |
| Synonyms: |
4-HYDROXYISOLEUCINE; 4-HYDROXY-L-ISOLEUCINE;HIL;HYDROXYISOLEUCINE, 4-;2-AMINO-2,3,5-TRIDEOXY-3-METHYL-D-XYLONIC ACID;(2S,3R,4S)-4-HYDROXYISOLEUCINE MAJOR ISOMER AND (2R,3R,4S)-4-HYDROXYISOLEUCINE MINOR ISOMER;[DISCONTINUED] Replaced by KIT-00008502-0HK;HYDROXYISOLEUCINE, 4-(FG);(2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid |
| CAS: |
55399-93-4 |
| MF: |
C6H13NO3 |
| MW: |
147.17 |
| EINECS: |
2017-001-1 |
| Product Categories: |
chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: |
55399-93-4.mol |
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| 4-HYDROXYISOLEUCINE Chemical Properties |
| Melting point |
223-224℃ |
| Boiling point |
331.6±32.0 °C(Predicted) |
| density |
1.181±0.06 g/cm3 (20 ºC 760 Torr) |
| Fp |
147℃ |
| storage temp. |
Keep in dark place,Inert atmosphere,2-8°C |
| solubility |
Methanol (Slightly), Water (Slightly) |
| pka |
2.41±0.25(Predicted) |
| form |
Solid |
| color |
White to Off-White |
| optical activity |
[α]/D +32.5±2.0°, c = 1 in H2O |
| BRN |
4128096 |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26 |
| WGK Germany |
3 |
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| 4-HYDROXYISOLEUCINE Usage And Synthesis |
| Description |
4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM. In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide (Item No. 11127) and streptozotocin (STZ; Item No. 13104) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes. |
| Uses |
(4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes. |
| Definition |
ChEBI: An L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent. |
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| 4-HYDROXYISOLEUCINE Preparation Products And Raw materials |
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Group profiles
Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
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