China Largest Manufacturer factory sales Glycylglycine CAS 556-50-3 CAS NO.556-50-3

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Glycylglycine Basic information Product Name: Glycylglycine Synonyms: (2-Amino-acetylamino)-aceticacid;[(Aminoacetyl)amino]acetic acid;DIGLYCINE;GLYCYLGLYCINE;GLY-GLY-OH;GLY-GLY;H-GLY-GLY-OH;Glycylglycine, Free Base CAS: 556-50-3 MF: C4H8N2O3 MW: 132.12 EINECS: 209-127-8 Product Categories: Peptide;Biochemistry;Oligopeptides;Peptide Synthesis;amino acid;buffer Mol File: 556-50-3.mol   Glycylglycine Chemical Properties Melting point  220-240 °C (dec.) Boiling point  267.18°C (rough estimate) density  1.5851 (rough estimate) refractive index  1.4880 (estimate) storage temp.  Keep in dark place,Inert atmosphere,Room temperature solubility  H2O: 1 M at 20 °C, clear, colorless pka 3.139(at 25℃) form  Solid color  White PH 4.5-6.0 (20℃, 1M in H2O) PH Range 7.5 - 8.9 Water Solubility  SOLUBLE IN HOT WATER λmax λ: 260 nm Amax: 0.075 λ: 280 nm Amax: 0.072 Merck  14,4503 BRN  1765223 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey YMAWOPBAYDPSLA-UHFFFAOYSA-N CAS DataBase Reference 556-50-3(CAS DataBase Reference) NIST Chemistry Reference N-Glycylglycine(556-50-3) EPA Substance Registry System Glycylglycine (556-50-3)   Safety Information Hazard Codes  Xi Risk Statements  36 Safety Statements  24/25-26 WGK Germany  3 F  10 TSCA  Yes HS Code  29241900 MSDS Information Provider Language N-Glycylglycine English SigmaAldrich English ACROS English ALFA English   Glycylglycine Usage And Synthesis Chemical Properties White crystals Uses Glycylglycine is as a buffering reagent and also used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. It is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption. Definition ChEBI: A dipeptide formed from glycine residues. Synthesis Reference(s) Journal of the American Chemical Society, 75, p. 5323, 1953 DOI: 10.1021/ja01117a053 Biochem/physiol Actions Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid. Diglycine is known to catalyze the formation of homo- and hetero dipeptides more efficiently than glycine. Purification Methods Crystallise glycylglycine from aqueous 50% EtOH or water at 50-60o by addition of EtOH. Dry it at 110o. It sublimes at 190-200o/0.3mm with 30% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955, King J Am Chem Soc 79 6153 1957]. [Beilstein 4 IV 2459.]   Glycylglycine Preparation Products And Raw materials Raw materials Ethylenediamine-->Glycyl-glycyl-glycine-->H-Gly-Gly-AMC-->CHLOROACETYL-GLYCYL-GLYCINE-->H-Gly-Gly-NH2-->diglycyl-histidine-->Cbz-Gly-Gly-->GLYCYLGLYCINE ETHYL ESTER HYDROCHLORIDE-->N-(tert-Butoxycarbonyl)glycylglycine-->Glycine methyl ester hydrochloride-->L-Histidine Preparation Products N-CHLOROACETYLGLYCINE-->N-OXALYL GLYCINE   D(+)-Galactosamine hydrochloride Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Glycylglycine Basic information Product Name: Glycylglycine Synonyms: (2-Amino-acetylamino)-aceticacid;[(Aminoacetyl)amino]acetic acid;DIGLYCINE;GLYCYLGLYCINE;GLY-GLY-OH;GLY-GLY;H-GLY-GLY-OH;Glycylglycine, Free Base CAS: 556-50-3 MF: C4H8N2O3 MW: 132.12 EINECS: 209-127-8 Product Categories: Peptide;Biochemistry;Oligopeptides;Peptide Synthesis;amino acid;buffer Mol File: 556-50-3.mol   Glycylglycine Chemical Properties Melting point  220-240 °C (dec.) Boiling point  267.18°C (rough estimate) density  1.5851 (rough estimate) refractive index  1.4880 (estimate) storage temp.  Keep in dark place,Inert atmosphere,Room temperature solubility  H2O: 1 M at 20 °C, clear, colorless pka 3.139(at 25℃) form  Solid color  White PH 4.5-6.0 (20℃, 1M in H2O) PH Range 7.5 - 8.9 Water Solubility  SOLUBLE IN HOT WATER λmax λ: 260 nm Amax: 0.075 λ: 280 nm Amax: 0.072 Merck  14,4503 BRN  1765223 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey YMAWOPBAYDPSLA-UHFFFAOYSA-N CAS DataBase Reference 556-50-3(CAS DataBase Reference) NIST Chemistry Reference N-Glycylglycine(556-50-3) EPA Substance Registry System Glycylglycine (556-50-3)   Safety Information Hazard Codes  Xi Risk Statements  36 Safety Statements  24/25-26 WGK Germany  3 F  10 TSCA  Yes HS Code  29241900 MSDS Information Provider Language N-Glycylglycine English SigmaAldrich English ACROS English ALFA English   Glycylglycine Usage And Synthesis Chemical Properties White crystals Uses Glycylglycine is as a buffering reagent and also used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. It is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption. Definition ChEBI: A dipeptide formed from glycine residues. Synthesis Reference(s) Journal of the American Chemical Society, 75, p. 5323, 1953 DOI: 10.1021/ja01117a053 Biochem/physiol Actions Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid. Diglycine is known to catalyze the formation of homo- and hetero dipeptides more efficiently than glycine. Purification Methods Crystallise glycylglycine from aqueous 50% EtOH or water at 50-60o by addition of EtOH. Dry it at 110o. It sublimes at 190-200o/0.3mm with 30% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955, King J Am Chem Soc 79 6153 1957]. [Beilstein 4 IV 2459.]   Glycylglycine Preparation Products And Raw materials Raw materials Ethylenediamine-->Glycyl-glycyl-glycine-->H-Gly-Gly-AMC-->CHLOROACETYL-GLYCYL-GLYCINE-->H-Gly-Gly-NH2-->diglycyl-histidine-->Cbz-Gly-Gly-->GLYCYLGLYCINE ETHYL ESTER HYDROCHLORIDE-->N-(tert-Butoxycarbonyl)glycylglycine-->Glycine methyl ester hydrochloride-->L-Histidine Preparation Products N-CHLOROACETYLGLYCINE-->N-OXALYL GLYCINE