China Largest Manufacturer factory sales Cystamine Dihydrochloride CAS56-17-7 CAS NO.56-17-7

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Cystamine dihydrochloride Basic information Product Name: Cystamine dihydrochloride Synonyms: 2,2’-dithiobis-ethanamindihydrochloride;2,2’-dithiobis-ethylamindihydrochloride;2-aminoethyldisulfidedihydrochloride;aed;Cystamine dihydrochloride, 98+%;bis-B-aminoethyldisulphide dihydrochloride;2,2μ-Diaminodiethyl disulfide dihydrochloride, 2,2μ-Dithiobis(ethylamine) dihydrochloride, Decarboxycystine dihydrochloride;Ethylamine, 2,2'-dithiobis-, dihydrochloride CAS: 56-17-7 MF: C4H14Cl2N2S2 MW: 225.2 EINECS: 200-260-7 Product Categories: Pyridines;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfides/Disulfides;Sulfur Compounds;Pharmaceutical Intermediates Mol File: 56-17-7.mol   Cystamine dihydrochloride Chemical Properties Melting point  217-220 °C (dec.)(lit.) storage temp.  Store below +30°C. solubility  H2O: soluble1.0g/10 mL, clear to almost clear, colorless to almost colorless (<5.5 NTU) form  Crystalline Powder, Crystals or Chunks color  White to yellow Water Solubility  soluble Sensitive  Hygroscopic Merck  14,2776 BRN  3616850 Stability: Stable. Incompatible with strong oxidizing agents. CAS DataBase Reference 56-17-7(CAS DataBase Reference) EPA Substance Registry System Ethanamine, 2,2'-dithiobis-, dihydrochloride (56-17-7)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38 Safety Statements  37/39-26-36/37/39 WGK Germany  3 RTECS  KR7260000 TSCA  Yes HazardClass  IRRITANT HS Code  29309070 MSDS Information Provider Language 2,2'-Dithiodi(ethylammonium) dichloride English ACROS English SigmaAldrich English ALFA English   Cystamine dihydrochloride Usage And Synthesis Chemical Properties white powder Uses hepatoprotectant, t-glutaminase inhibitor, heat shock protein promoter, caspase inhibitor Uses sulfhydryl modifying reagent and heparin antagonist Uses Cystamine dihydrochloride acts as an anti-infective agent, which is used in the treatment of urinary tract infections. It is also used as a radiation-protective agent that interferes with sulfhydryl enzymes. Further, it serves as a heparin antagonist and sulfhydryl modifying reagent. In addition to this, it is used as an inhibitor of TGase. Safety Profile A poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl, SOx, and NOx. See also SULFIDES. Purification Methods Recrystallise the salt by dissolving in EtOH containing a few drops of dry EtOH/HCl, filtering and adding dry Et2O. The solid is dried in a vacuum and stored in a dry and dark atmosphere. It has been recrystallised from EtOH (solubility: 1g in 60mL of boiling EtOH) or MeOH (plates). The free base has b 90-Purification of Biochemicals — Amino Acids and Peptides 100o/0.001mm, 106-108o/5mm and 135-136o/760mm, d 4 1.1559, n D 1.5720. [Verly & Koch Biochem J 58 663 1954, Gonick et al. J Am Chem Soc 76 4671 1954, Jackson & Block J Biol Chem 113 137 1936.] The dihydrobromide has m 238-239o (from EtOH/Et2O) [Viscontini Helv Chim Acta 36 835 1953]. [Beilstein 4 H 287, 4 IV 1578.]   Cystamine dihydrochloride Preparation Products And Raw materials Raw materials Cysteamine hydrochloride Preparation Products Bis[2-(dimethylamino)ethyl] persulfide

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Cystamine dihydrochloride Basic information Product Name: Cystamine dihydrochloride Synonyms: 2,2’-dithiobis-ethanamindihydrochloride;2,2’-dithiobis-ethylamindihydrochloride;2-aminoethyldisulfidedihydrochloride;aed;Cystamine dihydrochloride, 98+%;bis-B-aminoethyldisulphide dihydrochloride;2,2μ-Diaminodiethyl disulfide dihydrochloride, 2,2μ-Dithiobis(ethylamine) dihydrochloride, Decarboxycystine dihydrochloride;Ethylamine, 2,2'-dithiobis-, dihydrochloride CAS: 56-17-7 MF: C4H14Cl2N2S2 MW: 225.2 EINECS: 200-260-7 Product Categories: Pyridines;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfides/Disulfides;Sulfur Compounds;Pharmaceutical Intermediates Mol File: 56-17-7.mol   Cystamine dihydrochloride Chemical Properties Melting point  217-220 °C (dec.)(lit.) storage temp.  Store below +30°C. solubility  H2O: soluble1.0g/10 mL, clear to almost clear, colorless to almost colorless (<5.5 NTU) form  Crystalline Powder, Crystals or Chunks color  White to yellow Water Solubility  soluble Sensitive  Hygroscopic Merck  14,2776 BRN  3616850 Stability: Stable. Incompatible with strong oxidizing agents. CAS DataBase Reference 56-17-7(CAS DataBase Reference) EPA Substance Registry System Ethanamine, 2,2'-dithiobis-, dihydrochloride (56-17-7)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38 Safety Statements  37/39-26-36/37/39 WGK Germany  3 RTECS  KR7260000 TSCA  Yes HazardClass  IRRITANT HS Code  29309070 MSDS Information Provider Language 2,2'-Dithiodi(ethylammonium) dichloride English ACROS English SigmaAldrich English ALFA English   Cystamine dihydrochloride Usage And Synthesis Chemical Properties white powder Uses hepatoprotectant, t-glutaminase inhibitor, heat shock protein promoter, caspase inhibitor Uses sulfhydryl modifying reagent and heparin antagonist Uses Cystamine dihydrochloride acts as an anti-infective agent, which is used in the treatment of urinary tract infections. It is also used as a radiation-protective agent that interferes with sulfhydryl enzymes. Further, it serves as a heparin antagonist and sulfhydryl modifying reagent. In addition to this, it is used as an inhibitor of TGase. Safety Profile A poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl, SOx, and NOx. See also SULFIDES. Purification Methods Recrystallise the salt by dissolving in EtOH containing a few drops of dry EtOH/HCl, filtering and adding dry Et2O. The solid is dried in a vacuum and stored in a dry and dark atmosphere. It has been recrystallised from EtOH (solubility: 1g in 60mL of boiling EtOH) or MeOH (plates). The free base has b 90-Purification of Biochemicals — Amino Acids and Peptides 100o/0.001mm, 106-108o/5mm and 135-136o/760mm, d 4 1.1559, n D 1.5720. [Verly & Koch Biochem J 58 663 1954, Gonick et al. J Am Chem Soc 76 4671 1954, Jackson & Block J Biol Chem 113 137 1936.] The dihydrobromide has m 238-239o (from EtOH/Et2O) [Viscontini Helv Chim Acta 36 835 1953]. [Beilstein 4 H 287, 4 IV 1578.]   Cystamine dihydrochloride Preparation Products And Raw materials Raw materials Cysteamine hydrochloride Preparation Products Bis[2-(dimethylamino)ethyl] persulfide Product Name: Sodium carboxyl methylstarch Synonyms: sodium carboxyl methylstarch;SODIUM STARCH GLYCOLATE;SODIUM STARCH GLYCOLLATE;PRIMOJEL(R);CARBOXYMETHYL STARCH SODIUM;CARBOXYMETHYL STARCH SODIUM SALT;SodiumStarchGlycolateExtraPure;Primojel CAS: 9063-38-1 MF: C2H4O3·xNa·x MW: 0 EINECS: 618-597-7 Product Categories: 9063-38-1 Mol File: Mol File   Sodium carboxyl methylstarch Chemical Properties Melting point  >210°C (dec.) storage temp.  Inert atmosphere,Room Temperature solubility  Practically insoluble in methylene chloride. It gives a translucent suspension in water. form  neat color  White to Off-White CAS DataBase Reference 9063-38-1 EPA Substance Registry System Starch, carboxymethyl ether, sodium salt (9063-38-1)   Safety Information WGK Germany  1 HS Code  3505100092 MSDS Information   Sodium carboxyl methylstarch Usage And Synthesis Chemical Properties White or almost white, fine, free-flowing powder, very hygroscopic. Chemical Properties Sodium starch glycolate is a white or almost white free-flowing very hygroscopic powder. The PhEur 6.0 states that when examined under a microscope it is seen to consist of: granules, irregularly shaped, ovoid or pear-shaped, 30–100 mm in size, or rounded, 10–35 mm in size; compound granules consisting of 2–4 components occur occasionally; the granules have an eccentric hilum and clearly visible concentric striations. Between crossed nicol prisms, the granules show a distinct black cross intersecting at the hilum; small crystals are visible at the surface of the granules. The granules show considerable swelling in contact with water. Uses Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is recommended to use in tablets prepared by either directcompression or wet-granulation processes. Uses Sodium Starch Glycolate is a starch of potato origin with α1-4 short linear linkages and branched α1-6 linkages between glucose units. Used in the synthesis of capsules for delivery of drugs or medicaments. Production Methods Sodium starch glycolate is a substituted derivative of potato starch. Typically, commercial products are also crosslinked using either sodium trimetaphosphate (Types A and B) or dehydration (Type C). Starch is carboxymethylated by reacting it with sodium chloroacetate in an alkaline, nonaqueous medium, typically denatured ethanol or methanol, followed by neutralization with citric acid, acetic acid, or some other acid. Vivastar P is manufactured in methanolic medium, and Explotab in ethanolic medium. Pharmaceutical Applications Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is commonly used in tablets prepared by either direct-compression or wet-granulation processes. The usual concentration employed in a formulation is between 2% and 8%, with the optimum concentration about 4%, although in many cases 2% is sufficient. Disintegration occurs by rapid uptake of water followed by rapid and enormous swelling. Although the effectiveness of many disintegrants is affected by the presence of hydrophobic excipients such as lubricants, the disintegrant efficiency of sodium starch glycolate is unimpaired. Increasing the tablet compression pressure also appears to have no effect on disintegration time. Sodium starch glycolate has also been investigated for use as a suspending vehicle. Safety Sodium starch glycolate is widely used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may be harmful. storage Tablets prepared with sodium starch glycolate have good storage properties. Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking. The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity. Incompatibilities Sodium starch glycolate is incompatible with ascorbic acid. Regulatory Status Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Sodium carboxyl methylstarch Preparation Products And Raw materials Raw materials Acrylonitrile-->Sodium chloroacetate