China Largest Manufacturer factory Supply Chloroamphenicol CAS 56-75-7 CAS NO.56-75-7

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Chloramphenicol Basic information Description Chemical Properties Uses Antimicrobial Spectrum Mechanism of action Pharmacokinetics Indications resistance Drug interactions Adverse reactions and precautions Methods of production Product Name: Chloramphenicol Synonyms: ,[theta-(theta,theta)]-;[R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide;2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-acetamid;2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,[R-(R*,R*)]-Acetamide;2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamid;Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl);Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-;Acetamide, 2,2-dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)- CAS: 56-75-7 MF: C11H12Cl2N2O5 MW: 323.13 EINECS: 200-287-4 Product Categories: Pyridines;Active Pharmaceutical Ingredients;Antibiotics for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);Antibiotic Explorer;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;API;CHLOROMYCETIN;antibiotic;Pharmaceutical intermediates;Chiral Reagents;Pharmaceutical intermediate;56-75-7 Mol File: 56-75-7.mol   Chloramphenicol Chemical Properties Melting point  148-150 °C(lit.) alpha  19.5 º (c=6, EtOH) Boiling point  644.9±55.0 °C(Predicted) density  1.6682 (rough estimate) refractive index  20 ° (C=5, EtOH) Fp  14 °C storage temp.  Keep in dark place,Inert atmosphere,2-8°C solubility  absolute ethanol: soluble5-20mg/mL (as a stock solution) form  powder pka 11.03±0.46(Predicted) color  white Water Solubility  2.5 g/L (25 º C) Merck  14,2077 BRN  2225532 InChIKey WIIZWVCIJKGZOK-RKDXNWHRSA-N CAS DataBase Reference 56-75-7(CAS DataBase Reference) NIST Chemistry Reference Chloramphenicol(56-75-7) IARC 2A (Vol. Sup 7, 50) 1990 EPA Substance Registry System Chloramphenicol (56-75-7)   Safety Information Hazard Codes  T,F Risk Statements  45-11-39/23/24/25-23/24/25 Safety Statements  53-45-16-36/37 RIDADR  2811 WGK Germany  3 RTECS  AB6825000 F  3-10 TSCA  Yes HazardClass  3 HazardClass  IRRITANT HS Code  29414000 Hazardous Substances Data 56-75-7(Hazardous Substances Data) Toxicity LD50 oral in rat: 2500mg/kg MSDS Information Provider Language Chloromycetin English ACROS English SigmaAldrich English ALFA English   Chloramphenicol Usage And Synthesis Description Chloramphenicol, also known as chlornitromycin, is a broad-spectrum, bacteriostatic antibiotic derived from Streptomyces venezuelae. It is first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. The synthetic product is racemic, also called synthomycin. Syntomycin is a mixture of chloramphenicol L-isomer and d-isomer. Because of dextroisomer antibacterial effect, the effect of synthomycin is only half of the natural products. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It is effective against several gram-positive and gram-negative bacteria and commonly used in researching protein synthesis and to select for chloramphenicol-resistant transformed cells or the bacterial CAT gene. Chloramphenicol is a semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation. Chemical Properties It is white or yellowish green needle like crystals. The melting point is 150.5-151.5℃ (149.7-150.7℃). Under the high vacuum it can be sublimated, slightly soluble in water (2.5mg/ml at 25℃), slightly soluble in propylene glycol (150.8mg/ml), soluble in methanol, ethanol, butanol, ethyl acetate, acetone, insoluble in ether, benzene, petroleum ether, vegetable oil. Taste is very bitter. Uses Chloramphenicol is used for the treatment caused by typhoid bacillus, dysentery bacillus, Escherichia coli, bacillus, influenza and pneumococcal infections such as brucellosis. Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth. Chloramphenicol is used to treat serious infections in different parts of the body. It is sometimes given with other antibiotics. However, chloramphenicol should not be used for colds, flu, other virus infections, sore throats or other minor infections, or to prevent infections. Chloramphenicol should only be used for serious infections in which other medicines do not work. This medicine may cause some serious side effects, including blood problems and eye problems. Symptoms of the blood problems include pale skin, sore throat and fever, unusual bleeding or bruising, and unusual tiredness or weakness. You and your doctor should talk about the good this medicine will do as well as the risks of taking it . Chloramphenicol is available only with your doctor's prescription.

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Chloramphenicol Basic information Description Chemical Properties Uses Antimicrobial Spectrum Mechanism of action Pharmacokinetics Indications resistance Drug interactions Adverse reactions and precautions Methods of production Product Name: Chloramphenicol Synonyms: ,[theta-(theta,theta)]-;[R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide;2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-acetamid;2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,[R-(R*,R*)]-Acetamide;2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamid;Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl);Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-;Acetamide, 2,2-dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)- CAS: 56-75-7 MF: C11H12Cl2N2O5 MW: 323.13 EINECS: 200-287-4 Product Categories: Pyridines;Active Pharmaceutical Ingredients;Antibiotics for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);Antibiotic Explorer;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;API;CHLOROMYCETIN;antibiotic;Pharmaceutical intermediates;Chiral Reagents;Pharmaceutical intermediate;56-75-7 Mol File: 56-75-7.mol   Chloramphenicol Chemical Properties Melting point  148-150 °C(lit.) alpha  19.5 º (c=6, EtOH) Boiling point  644.9±55.0 °C(Predicted) density  1.6682 (rough estimate) refractive index  20 ° (C=5, EtOH) Fp  14 °C storage temp.  Keep in dark place,Inert atmosphere,2-8°C solubility  absolute ethanol: soluble5-20mg/mL (as a stock solution) form  powder pka 11.03±0.46(Predicted) color  white Water Solubility  2.5 g/L (25 º C) Merck  14,2077 BRN  2225532 InChIKey WIIZWVCIJKGZOK-RKDXNWHRSA-N CAS DataBase Reference 56-75-7(CAS DataBase Reference) NIST Chemistry Reference Chloramphenicol(56-75-7) IARC 2A (Vol. Sup 7, 50) 1990 EPA Substance Registry System Chloramphenicol (56-75-7)   Safety Information Hazard Codes  T,F Risk Statements  45-11-39/23/24/25-23/24/25 Safety Statements  53-45-16-36/37 RIDADR  2811 WGK Germany  3 RTECS  AB6825000 F  3-10 TSCA  Yes HazardClass  3 HazardClass  IRRITANT HS Code  29414000 Hazardous Substances Data 56-75-7(Hazardous Substances Data) Toxicity LD50 oral in rat: 2500mg/kg MSDS Information Provider Language Chloromycetin English ACROS English SigmaAldrich English ALFA English   Chloramphenicol Usage And Synthesis Description Chloramphenicol, also known as chlornitromycin, is a broad-spectrum, bacteriostatic antibiotic derived from Streptomyces venezuelae. It is first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. The synthetic product is racemic, also called synthomycin. Syntomycin is a mixture of chloramphenicol L-isomer and d-isomer. Because of dextroisomer antibacterial effect, the effect of synthomycin is only half of the natural products. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It is effective against several gram-positive and gram-negative bacteria and commonly used in researching protein synthesis and to select for chloramphenicol-resistant transformed cells or the bacterial CAT gene. Chloramphenicol is a semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blocks peptide bond formation. As a result bacterial protein synthesis is blocked and impede bacterial cell proliferation. Chemical Properties It is white or yellowish green needle like crystals. The melting point is 150.5-151.5℃ (149.7-150.7℃). Under the high vacuum it can be sublimated, slightly soluble in water (2.5mg/ml at 25℃), slightly soluble in propylene glycol (150.8mg/ml), soluble in methanol, ethanol, butanol, ethyl acetate, acetone, insoluble in ether, benzene, petroleum ether, vegetable oil. Taste is very bitter. Uses Chloramphenicol is used for the treatment caused by typhoid bacillus, dysentery bacillus, Escherichia coli, bacillus, influenza and pneumococcal infections such as brucellosis. Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth. Chloramphenicol is used to treat serious infections in different parts of the body. It is sometimes given with other antibiotics. However, chloramphenicol should not be used for colds, flu, other virus infections, sore throats or other minor infections, or to prevent infections. Chloramphenicol should only be used for serious infections in which other medicines do not work. This medicine may cause some serious side effects, including blood problems and eye problems. Symptoms of the blood problems include pale skin, sore throat and fever, unusual bleeding or bruising, and unusual tiredness or weakness. You and your doctor should talk about the good this medicine will do as well as the risks of taking it . Chloramphenicol is available only with your doctor's prescription.