China Largest Manufacturer factory SupplyFood/Feed Grade DL-Methionine CAS 59-51-8 CAS NO.59-51-8

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Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 306.9±37.0 °C at 760 mmHg Melting Point 270-273ºC Molecular Formula C5H11NO2S Molecular Weight 149.211 Flash Point 139.4±26.5 °C Exact Mass 149.051056 PSA 88.62000 LogP 0.37 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.531 Storage condition 0-6°C Stability Stable. Incompatible with strong oxidising agents. Water Solubility 1 M HCl: 0.5 M at 20 °C, clear, colorless | 2.9 g/100 mL (20 ºC) Item Specification Test Results Appearance White or Light Grey Crystal Light Grey Crystal Loss on Drying (%) ≤0.3 0.1 Chloride (NaCl) (%) ≤0.2 ＜0.2 Heavy Metal (Pb)(mg/kg) ≤20 ＜20 As(mg/kg) ≤2 ＜2 DL-Methionine (%) ≥99.0 99.10 DL-Methionine Basic information Description References Product Name: DL-Methionine Synonyms: (R,S)-2-Amino-4-methylsulfanyl-butyricacid;(RS)-2-Amino-3-methylthiobutansαure;Metione;Neston;Pedameth;Petameth;Thiomedon;Urimeth CAS: 59-51-8 MF: C5H11NO2S MW: 149.21 EINECS: 200-432-1 Product Categories: Amino Acids;Amino Acids;Amino Acid Derivatives;Methionine [Met, M];feed additives Mol File: 59-51-8.mol   DL-Methionine Chemical Properties Melting point  284 °C (dec.)(lit.) alpha  -1～+1°(D/20℃)(c=8,HCl) Boiling point  306.9±37.0 °C(Predicted) density  1.34 FEMA  3301 | D,L-METHIONINE refractive index  1.5216 (estimate) storage temp.  2-8°C solubility  1 M HCl: 0.5 M at 20 °C, clear, colorless pka 2.13(at 25℃) form  Crystals or Crystalline Powder color  White optical activity [α]/D, c = 5 in 5 M HCl (inactive) Water Solubility  2.9 g/100 mL (20 ºC) JECFA Number 1424 Merck  14,5975 BRN  636185 Stability: Stable. Incompatible with strong oxidising agents. InChIKey FFEARJCKVFRZRR-UHFFFAOYSA-N CAS DataBase Reference 59-51-8(CAS DataBase Reference) NIST Chemistry Reference Methionine(59-51-8) EPA Substance Registry System Methionine (59-51-8)   Safety Information Hazard Codes  Xi Risk Statements  33-36/37/38 Safety Statements  24/25-36-26 WGK Germany  2 RTECS  PD0457000 F  10-23 TSCA  Yes HS Code  29304090 MSDS Information Provider Language Acimetion English SigmaAldrich English ACROS English ALFA English   DL-Methionine Usage And Synthesis Description Methionine (2-amino-4(methylthio)-butanoic acid) is one of the essential amino acids, which are used by our bodies to make proteins and can only be supplied by diets. Methionine is found in metal, fish, and dairy products, and it plays an important role in many cell functions. With an asymmetric carbon, methionine molecules can be D (Dextrogyre) or L (Levogyre), optical isomers. L-methionine is the biologically active form of methionine in proteins. D-methionine is converted into L-methionine by enzymatic processes inside animal bodies in such a way that L- and D-methionine are equivalent for animal nutrition. D,L-methionine (DLM) is the most common form of commercialized methionine, composed of the racemic mixture of D and L-methionine.  D,L-methionine is commercialized as a white crystalline powder, containing 99% of active substance, or in a brown liquid form with 40% purity, made from the dissolution of D,L-methionine in sodium hydroxide. Methionine is used to prevent liver damage in acetaminophen (Tylenol) poisoning. It is also used to increase the acidity of urine, to treat liver disorders, and to improve wound healing. Furthermore, it is used for the treatment of depression, alcoholism, allergies, asthma, copper poisoning, radiation side effects, schizophrenia, drug withdrawal, and Parkinson's disease. Methionine is registered as an ingredient for use in cosmetics as antistatic and for skin conditioning (Commission Decision 2006/257/EC). D,L-methionine is used in animal feeds for poultry and pigs, as well as in diets for cats and dogs. D,L-methionine technically pure protected with copolymer vinylpyridine/styrene, and D,L-methionine protected with ethylcellulose when used as a feed additive for ruminants, are currently authorized for use for all animal species and ruminants, respectively, by Regulation (EU) No 469/2013. References [1] DL-Methionine from Methional and Hyddrogen Cyanide – Cost Analysis – Methionine E11A (2016) [2] # [3] # Description Methionine is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CH2SCH3. This essential amino acid is classified as nonpolar. This amino-acid is coded by the initiation codon AUG which indicates mRNA's coding region where translation into protein begins. Chemical Properties White crystalline powder Chemical Properties White, crystalline platelets or powder having a characteristic odor. One g dissolves in about 30 mL of water. It is soluble in dilute acids and in solutions of alkali hydroxides. It is very slightly soluble in alcohol, and practically insoluble in ether. It is optically inactive. The pH of a 1 in 100 solution is between 5.6 and 6.1. This substance may be prepared by addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde. Chemical Properties d,l-Methionine has a characteristic odor. It is an essential amino acid and is also used as a nutrient and dietary supplement. Occurrence High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. Racemic methionine is sometimes added as an ingredient to pet foods. Uses Production of volatile compounds related to the flavour of foods from the Strecker degradation of DL-methionine. Addition of methionine in appropriate amounts to these foods might be expected to improve protein value. Economically, DL-methionine would be preferable. Uses An essential nonpolar amino acid with oxidative stress defense properties Uses DL-Methionine is sometimes given as a supplement to dogs; it helps keep dogs from damaging grass by reducing the pH of the urine. Methionine is allowed as a supplement to organic poultry feed under the US certified organic program. Definition ChEBI: A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4. Preparation By addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde. Brand name Pedameth (Forest). Biosynthesis As an essential amino acid, methionine is not synthesized de novo in humans, who must ingest methionine or methioninecontaining proteins. In plants and microorganisms, methionine is synthesized via a pathway that uses both aspartic acid and cysteine. First, aspartic acid is converted via β-aspartyl-semialdehyde into homoserine, introducing the pair of contiguous methylene groups. Homoserine converts to O-succinyl homoserine, which then reacts with cysteine to produce cystathionine, which is cleaved to yield homocysteine. Subsequent methylation of the thiol group by folates affords methionine. Both cystathionine-γ-synthase and cystathionine- β-lyase require pyridoxyl-5′-phosphate as a cofactor, whereas homocysteine methyltransferase requires vitamin B12 as a cofactor. Biotechnological Production DL-Methionine is the second amino acid that is almost exclusively manufactured by chemical synthesis. The process used today was originally developed by Werner Schwarze at Degussa in the 1940s, and has been continually improved and refined since. Today DL-methionine is manufactured in several plants, each with a capacity of more than 100,000 tonnes. To operate the process on an industrial scale also requires back-integration into the key hazardous raw materials acrolein, methyl mercaptan, and hydrogen cyanide. After the formation of the hydantoin, the key step is alkaline hydrolysis of the hydantoin, to produce methionine directly in up to 95 % yield based on acrolein. Biological Functions Together with cysteine, methionine is one of two sulfurcontaining proteinogenic amino acids. Its derivative S-adenosyl methionine (SAM) serves as a methyl donor. Methionine is an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine, and other phospholipids. Improper conversion of methionine can lead to atherosclerosis. This amino acid is also used by plants for synthesis of ethylene. The process is known as the Yang Cycle or the methionine cycle. Methionine is one of only two amino acids encoded by a single codon (AUG) in the standard genetic code (tryptophan, encoded by UGG, is the other). The codon AUG is also the most common eukaryote "Start" message for a ribosome that signals the initiation of protein translation from mRNA when the AUG codon is in a Kozak consensus sequence. As a consequence, methionine is often incorporated into the N-terminal position of proteins in eukaryotes and archaea during translation, although it can be removed by post-translational modification. In bacteria, the derivative Nformylmethionine is used as the initial amino acid. General Description DL-Methionine is an essential amino acid containing sulphur. Methionine consists of an asymmetric carbon and exists as D (dextrogyre) and L (levogyre) optical isomers. The L-methionine is considered as biologically active. The racemic mixture of D and L-isomers forms DL-methionine, which is the commercially available methionine. Biochem/physiol Actions Methionine offers protection against disorders related to hair, skin and nails. It elevates lecithin production in the liver and thereby reduces cholesterol level. It naturally serves as a heavy metal chelating agent, regulating ammonia concentration in the urine. This ameliorates bladder irritation. Methionine is also known to induce hair growth. Safety Profile Moderately toxic by ingestion and other routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. See also 1-METHIONINE. Purification Methods Crystallise it from hot water or EtOH. Also purify it by dissolving it in H2O and passing through an Amberlite IR-120 resin (NH4+ form). The eluate is concentrated and then passed through Amberlite IR-4B resin, and this eluate is evaporated to dryness. The residue is washed with EtOH, then Me2CO, dried and recrystallised from aqueous EtOH (colourless plates) [Baddiley & Jamieson J Chem Soc 4283 1954]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2125 1961, Beilstein 4 IV 3190.] Other biochemical pathways Although mammals cannot synthesize methionine, they can still use it in a variety of biochemical pathways: Generation of homocysteine Methionine is converted to S-adenosyl methionine (SAM) by (1) methionine adenosyltransferase. SAM serves as a methyl-donor in many (2) methyl transferase reactions, and is converted to S-adenosylhomocysteine (SAH). (3) Adenosyl homocysteinase converts SAH to homocysteine. There are two fates of homocysteine: it can be used to regenerate methionine, or to form cysteine. Regeneration of methionine Methionine can be regenerated from homocysteine via methionine synthase in a reaction that requires Vitamin B12 as a cofactor. Homocysteine can also be remethylated using glycine betaine (NNN-trimethyl glycine, TMG) to methionine via the enzyme betainehomocysteine methyltransferase (E.C.2.1.1.5, BHMT). BHMT makes up to 1.5% of all the soluble protein of the liver, and recent evidence suggests that it may have a greater influence on methionine and homocysteine homeostasis than methionine synthase.   DL-Methionine Preparation Products And Raw materials Raw materials Sodium cyanide-->Water-->Ammonium bicarbonate-->Acrolein-->Cupric acetate monohydrate-->METHYL MERCAPTAN-->L-Methionine Preparation Products Meprobamate-->Zinc methionine sulfate-->D-Methionine-->(METHYLTHIO)ACETIC ACID   Phlorizin Preparation Products And Raw materials

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Product Name:	DL-Methionine
Synonyms:	(R,S)-2-Amino-4-methylsulfanyl-butyricacid;(RS)-2-Amino-3-methylthiobutansαure;Metione;Neston;Pedameth;Petameth;Thiomedon;Urimeth
CAS:	59-51-8
MF:	C5H11NO2S
MW:	149.21
EINECS:	200-432-1
Product Categories:	Amino Acids;Amino Acids;Amino Acid Derivatives;Methionine [Met, M];feed additives
Mol File:	59-51-8.mol