China Biggest Manufacturer factory sales Betaine Hydrochloride CAS 590-46-5 CAS NO.590-46-5

                                PRODUCT DETAILS                           

Betaine hydrochloride Basic information Product Name: Betaine hydrochloride Synonyms: Betaine Hydrochloride, AR;acidolhydrochloride;Acidol-Pepsin;Acinorm;Acipepsol;Aciventral forte;aciventralforte;Ammonium, (carboxymethyl)trimethyl-, chloride CAS: 590-46-5 MF: C5H12ClNO2 MW: 153.61 EINECS: 209-683-1 Product Categories: chemical reagent;Herb extract;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis;Plant extracts;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;NOVASTAT;feed additives;Inhibitors Mol File: 590-46-5.mol   Betaine hydrochloride Chemical Properties Melting point  241-242 °C(lit.) FEMA  4223 | BETAINE storage temp.  room temp solubility  H2O: 1 M at 20 °C, clear, colorless form  Powder or Crystals color  Colorless to white PH 1 (50g/l, H2O, 20℃) Water Solubility  64.7 g/100 mL (25 ºC) Merck  14,1179 BRN  3916181 InChIKey HOPSCVCBEOCPJZ-UHFFFAOYSA-N CAS DataBase Reference 590-46-5(CAS DataBase Reference) NIST Chemistry Reference Betaine hydrochloride(590-46-5) EPA Substance Registry System Betaine hydrochloride (590-46-5)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36-36/37/38-20/21/22 Safety Statements  26-39-24/25-36 WGK Germany  3 RTECS  BP3136000 F  3-10 Autoignition Temperature 400 °C TSCA  Yes HS Code  29239000 MSDS Information Provider Language 1-Carboxy-N,N,N-trimethylmethanaminium chloride English SigmaAldrich English ACROS English ALFA English   Betaine hydrochloride Usage And Synthesis Description Betaine hydrochloride is a vitamin-like substance that is a source of hydrochloric acid and aids the production of stomach acid. Gastric acid also helps protect the gastrointestinal tract from harmful bacteria. A normal level of gastric acid in the stomach—100,000-1,000,000 times more acidic than water—is sufficient to destroy bacteria, but some people produce deficient amounts of stomach acid, a condition that may lead to bacterial and parasitic infections of the intestines. One study showed that fasting people with normal gastric acid levels in the stomach had almost no bacteria in the small in- testine, while individuals with low levels of hydrochloric acid had some bacterial colonization in the stomach.Betaine hydrochloride is therefore recommended by some medical practitioners to sustain a healthy and normal production of stomach acid, especially to those that suffer from disorders such as allergies and asthma. Betaine hydrochloride is a synthesized chemical, and is not obtained from any plant or animal source. Gastric acid is produced by stomach cells, and is not available from any food source. Occasionally, betaine (C5H11NO2 )is recommended to reduce blood levels of homocysteine, which is associated with heart disease. This form of betaine is different from betaine hydrochlo- ride, and is available only with a doctor’s prescription. Chemical Properties colorless to white crystals Uses Betaine hydrochloride can be used as antiarteriosclerotic, hypolipaemic, hepatoprotectant. Uses antiprotozoal, coccidiostat Uses Betaine is used as gastric acidifier.naturopaths have long held that low stomach acid is a widespread problem that interferes with the digestion and absorption of nutrients. Betaine hydrochloride is one of the most common recommendations for this condi- tion. It helps make some minerals and other nutrients more absorbable, and may be especially helpful with nu- tritional supplements, which are often taken in tablets or capsules that may not be easily digested. Indications Betaine hydrochloride may be used as a lipotropic. Lipotropics aid in preventing the accumulation of fat in the liver, and usually help in the detoxification of metabolic wastes and toxins. They may be used to help with weight loss. Betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria, a condition in which an abnormally low amount of hydrochloric acid is in the stomach. It has been used in preparations for the treatment of liver disorders, hypokalaemia (abnormally low levels of potassium in the blood), CO2 production in double contrast radiography, and high homocysteine. Betaine hydrochloride has also been used to treat tic douloreux (a condition which involves spasmodic pain along the course of a facial nerve), cystinuria (a hereditary defect that results in recurrent kidney stone formation), and vitiligo (a condition that is characterized by milky-white patches on otherwise normal skin). Biological Functions Betaine hydrochloride and pepsin are naturally occurring gastric-juice components that render nutrients available for absorption and biological acitivity. Specifically, Betaine hydrochloride is an acidic form of betaine, which promotes optimal gastric lumen acidity and pepsin is a protein-digesting enzyme that catalyzes the splitting of peptide bonds. Betaine HCl is an excellent source of hydrochloric acid, also known as stomach acid. Supplementing with betaine HCl can be very beneficial, as insufficient production of hydrochloric acid is fairly widespread and often overlooked. Certain situations, such as normal aging, can decrease the body’s natural production of HCl. General Description Betaine (trimethyl glycine) is an osmoprotectant, which is highly effective than proline. It is formed in from choline. Betaine is usually present in grains, spinach, beets, broccoli, shellfish and marine algae. Biochem/physiol Actions Betaine hydrochloride can decrease hepatotoxicity, that is stimulated by ethanol. Clinical Use Betaine hydrochloride (pronounced beta-een) is the acid form of trimethyiglycine (TMG). It is available as an over-the-counter drug. The most common use of betaine hydrochloride is as digestive aid for people who suffer from low gastric acidity (hypochlorhydria), a common complaint in the elderly and a cause of chronic indigestion. Although such a practice is unwise. betaine hydrochloride can be of use in cases of overeating. Gourmands, in particular, suffer less discomfort after indulgences if they take betaine hydrochloride with their feasts. Betaine hydrochloride is not only a digestive aid, but it also confers all the benefits of TMG (see next). However, betaine hydrochloride should not be used by anyone with chronic indigestion or heartburn without first seeking medical evaluation of the problem to make sure that there is not a more serious underlying condition. such as stomach ulcers. Betaine hydrochloride should be taken only with meals, and then only after first eating a few bites of food. The usual dose of betaine hydrochloride for hypochlorhydria is 500 milligrams. which is equivalent to 1.1 cubic centimeter (about a quarter teaspoon) of pharmaceutical Dilute Hydrochloric acid. Side effects Side effects are seldom seen, but as of 2013 betaine hydrochloride had not been through rigorous safety studies. Its safety, especially for young children, pregnant or nursing women, or those with severe liver or kidney disease, is not known. In very high doses, betaine hydrochlorine has been associated with heartburn or burning of the stomach lining. Drug interactions People taking nonsteroidal anti-inflammatory drugs (NSAIDs), cortisone-like drugs, or other medications that could cause peptic ulcers should not take betaine hy- drochloride. Purification Methods Recrystallise the salt from EtOH. Its solubility at 25o is 65% in H2O, and 5% in EtOH. [Edsall J Am Chem Soc 66 1767 1943, Kuhn & Ruelius Chem Ber 83 420 1950, Beilstein 4 III 1127, IV 2369.] Precautions People with a history of ulcers, heartburn, or other gastrointestinal symptoms should see a nutritionally oriented doctor before taking betaine hydrochloride, and no one should take more than 10 grains (650 mg) without a physician's recommendation. Large amounts of betaine hydrochloride can burn the lining of the stomach. If a burning sensation is experienced, betaine hydrochloride should be immediately discontinued.   Betaine hydrochloride Preparation Products And Raw materials Raw materials Sodium hydroxide-->Chloroacetic acid-->Trimethylamine

                                Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

Betaine hydrochloride Basic information Product Name: Betaine hydrochloride Synonyms: Betaine Hydrochloride, AR;acidolhydrochloride;Acidol-Pepsin;Acinorm;Acipepsol;Aciventral forte;aciventralforte;Ammonium, (carboxymethyl)trimethyl-, chloride CAS: 590-46-5 MF: C5H12ClNO2 MW: 153.61 EINECS: 209-683-1 Product Categories: chemical reagent;Herb extract;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis;Plant extracts;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;NOVASTAT;feed additives;Inhibitors Mol File: 590-46-5.mol   Betaine hydrochloride Chemical Properties Melting point  241-242 °C(lit.) FEMA  4223 | BETAINE storage temp.  room temp solubility  H2O: 1 M at 20 °C, clear, colorless form  Powder or Crystals color  Colorless to white PH 1 (50g/l, H2O, 20℃) Water Solubility  64.7 g/100 mL (25 ºC) Merck  14,1179 BRN  3916181 InChIKey HOPSCVCBEOCPJZ-UHFFFAOYSA-N CAS DataBase Reference 590-46-5(CAS DataBase Reference) NIST Chemistry Reference Betaine hydrochloride(590-46-5) EPA Substance Registry System Betaine hydrochloride (590-46-5)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36-36/37/38-20/21/22 Safety Statements  26-39-24/25-36 WGK Germany  3 RTECS  BP3136000 F  3-10 Autoignition Temperature 400 °C TSCA  Yes HS Code  29239000 MSDS Information Provider Language 1-Carboxy-N,N,N-trimethylmethanaminium chloride English SigmaAldrich English ACROS English ALFA English   Betaine hydrochloride Usage And Synthesis Description Betaine hydrochloride is a vitamin-like substance that is a source of hydrochloric acid and aids the production of stomach acid. Gastric acid also helps protect the gastrointestinal tract from harmful bacteria. A normal level of gastric acid in the stomach—100,000-1,000,000 times more acidic than water—is sufficient to destroy bacteria, but some people produce deficient amounts of stomach acid, a condition that may lead to bacterial and parasitic infections of the intestines. One study showed that fasting people with normal gastric acid levels in the stomach had almost no bacteria in the small in- testine, while individuals with low levels of hydrochloric acid had some bacterial colonization in the stomach.Betaine hydrochloride is therefore recommended by some medical practitioners to sustain a healthy and normal production of stomach acid, especially to those that suffer from disorders such as allergies and asthma. Betaine hydrochloride is a synthesized chemical, and is not obtained from any plant or animal source. Gastric acid is produced by stomach cells, and is not available from any food source. Occasionally, betaine (C5H11NO2 )is recommended to reduce blood levels of homocysteine, which is associated with heart disease. This form of betaine is different from betaine hydrochlo- ride, and is available only with a doctor’s prescription. Chemical Properties colorless to white crystals Uses Betaine hydrochloride can be used as antiarteriosclerotic, hypolipaemic, hepatoprotectant. Uses antiprotozoal, coccidiostat Uses Betaine is used as gastric acidifier.naturopaths have long held that low stomach acid is a widespread problem that interferes with the digestion and absorption of nutrients. Betaine hydrochloride is one of the most common recommendations for this condi- tion. It helps make some minerals and other nutrients more absorbable, and may be especially helpful with nu- tritional supplements, which are often taken in tablets or capsules that may not be easily digested. Indications Betaine hydrochloride may be used as a lipotropic. Lipotropics aid in preventing the accumulation of fat in the liver, and usually help in the detoxification of metabolic wastes and toxins. They may be used to help with weight loss. Betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria, a condition in which an abnormally low amount of hydrochloric acid is in the stomach. It has been used in preparations for the treatment of liver disorders, hypokalaemia (abnormally low levels of potassium in the blood), CO2 production in double contrast radiography, and high homocysteine. Betaine hydrochloride has also been used to treat tic douloreux (a condition which involves spasmodic pain along the course of a facial nerve), cystinuria (a hereditary defect that results in recurrent kidney stone formation), and vitiligo (a condition that is characterized by milky-white patches on otherwise normal skin). Biological Functions Betaine hydrochloride and pepsin are naturally occurring gastric-juice components that render nutrients available for absorption and biological acitivity. Specifically, Betaine hydrochloride is an acidic form of betaine, which promotes optimal gastric lumen acidity and pepsin is a protein-digesting enzyme that catalyzes the splitting of peptide bonds. Betaine HCl is an excellent source of hydrochloric acid, also known as stomach acid. Supplementing with betaine HCl can be very beneficial, as insufficient production of hydrochloric acid is fairly widespread and often overlooked. Certain situations, such as normal aging, can decrease the body’s natural production of HCl. General Description Betaine (trimethyl glycine) is an osmoprotectant, which is highly effective than proline. It is formed in from choline. Betaine is usually present in grains, spinach, beets, broccoli, shellfish and marine algae. Biochem/physiol Actions Betaine hydrochloride can decrease hepatotoxicity, that is stimulated by ethanol. Clinical Use Betaine hydrochloride (pronounced beta-een) is the acid form of trimethyiglycine (TMG). It is available as an over-the-counter drug. The most common use of betaine hydrochloride is as digestive aid for people who suffer from low gastric acidity (hypochlorhydria), a common complaint in the elderly and a cause of chronic indigestion. Although such a practice is unwise. betaine hydrochloride can be of use in cases of overeating. Gourmands, in particular, suffer less discomfort after indulgences if they take betaine hydrochloride with their feasts. Betaine hydrochloride is not only a digestive aid, but it also confers all the benefits of TMG (see next). However, betaine hydrochloride should not be used by anyone with chronic indigestion or heartburn without first seeking medical evaluation of the problem to make sure that there is not a more serious underlying condition. such as stomach ulcers. Betaine hydrochloride should be taken only with meals, and then only after first eating a few bites of food. The usual dose of betaine hydrochloride for hypochlorhydria is 500 milligrams. which is equivalent to 1.1 cubic centimeter (about a quarter teaspoon) of pharmaceutical Dilute Hydrochloric acid. Side effects Side effects are seldom seen, but as of 2013 betaine hydrochloride had not been through rigorous safety studies. Its safety, especially for young children, pregnant or nursing women, or those with severe liver or kidney disease, is not known. In very high doses, betaine hydrochlorine has been associated with heartburn or burning of the stomach lining. Drug interactions People taking nonsteroidal anti-inflammatory drugs (NSAIDs), cortisone-like drugs, or other medications that could cause peptic ulcers should not take betaine hy- drochloride. Purification Methods Recrystallise the salt from EtOH. Its solubility at 25o is 65% in H2O, and 5% in EtOH. [Edsall J Am Chem Soc 66 1767 1943, Kuhn & Ruelius Chem Ber 83 420 1950, Beilstein 4 III 1127, IV 2369.] Precautions People with a history of ulcers, heartburn, or other gastrointestinal symptoms should see a nutritionally oriented doctor before taking betaine hydrochloride, and no one should take more than 10 grains (650 mg) without a physician's recommendation. Large amounts of betaine hydrochloride can burn the lining of the stomach. If a burning sensation is experienced, betaine hydrochloride should be immediately discontinued.   Betaine hydrochloride Preparation Products And Raw materials Raw materials Sodium hydroxide-->Chloroacetic acid-->Trimethylamine