China Largest Manufacturer factory sales Guanidine Carbonate CAS 593-85-1 CAS NO.593-85-1

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Guanidine carbonate Basic information High purity Guanidine carbonate synthesis method Reference quality standards A preliminary study of ionic liquid solvent for the extraction of uranyl ion Chemical Properties Uses production method Product Name: Guanidine carbonate Synonyms: Carbonic acid, compound with guanidine (1:2);Guanidine·carbonic acid;Guanidne carbonate;Guanidinium carbonate, synthesis grade;Carbonicacid,compd.withguanidine(1:1);Carbonicacid,compd.withguanidine(1:2);Guanidonium-carbonat;Iminoureacarbonate CAS: 593-85-1 MF: C2H7N3O3 MW: 121.1 EINECS: 209-813-7 Product Categories: Building Blocks;Chemical Synthesis;Guanidines;Nitrogen Compounds;Nitrogen Compounds;Organic Building Blocks;Pharmaceutical Intermediates;Organic Building Blocks;593-85-1 Mol File: 593-85-1.mol   Guanidine carbonate Chemical Properties Melting point  >300 °C(lit.) density  1.25 storage temp.  Store below +30°C. solubility  450g/l form  Crystalline Powder color  White to almost white PH 11.7 (110g/l, H2O, 20℃) Water Solubility  450 g/L (20 ºC) BRN  3628359 InChIKey KMSRVXJGTIRNNK-UHFFFAOYSA-N CAS DataBase Reference 593-85-1(CAS DataBase Reference) NIST Chemistry Reference Guanidine carbonate(593-85-1) EPA Substance Registry System Guanidine carbonate (2:1) (593-85-1)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38-20/21/22 Safety Statements  26-36-22 WGK Germany  3 RTECS  FG1750000 Autoignition Temperature 530 °C TSCA  Yes HS Code  29252000 Toxicity LD50 orally in Rabbit: 1045 mg/kg MSDS Information Provider Language Guanidine carbonate English ACROS English SigmaAldrich English ALFA English   Guanidine carbonate Usage And Synthesis High purity Guanidine carbonate synthesis method Guanidine carbonate is an extremely versatile organic chemical products, it is mainly used in flame retardants, flocculants, foaming agents, synthetic sulfa drugs, etc. Guanidine carbonate is also used as synthetic detergent builders, high-quality cosmetics raw materials.Synthesis of guanidine carbonate is reported by many literatures [1-3] .The main domestic guanidine carbonate production is that molt dicyandiamide and ammonium chloride to generate guanidine hydrochloride, generate free guanidine under the action of the alkali, and then by the reaction of free guanidine and carbon dioxide to produce guanidine carbonate. this route is easy to generate melamine and its dimers, trimers and other impurities because of the high-temperature melting , and the presence of Cl-, Na + in the system is difficult to completely removed , even if the purity is> 99% of guanidine carbonate, its ash content is still up 0.2%, it is difficult to obtain high purity guanidine carbonate. in this paper, cyanamide as raw materials, reacts with carbon dioxide and ammonia in one step synthesis of guanidine carbonate, also known as ash-free guanidine carbonate, and then purify , to obtain a high purity guanidine carbonate, the reaction equation is as follows: 2NH2CN + CO2 + 2NH3 + H20 → [NH2C (: NH) NH2] 2H2CO3 Author: Zhouzhao Liang Xie Jianwei Zhou Xiaohong Jiang Yongqing Author: Zhouzhao Liang, Xie Jianwei (Research Institute of Zhejiang University of West Branch Quzhou 324006) Zhou Xiaohong, Jiang Yongqing (Institute of Fine Chemicals Group Technology Center Juhua Quzhou 324004) Reference quality standards [Industry Grade ] Name of Item Technical index Premium grade B product Appearance white crystalline white powder Content of ≥ 99% 98% Ammonium ≤ 0.45% 1.0% Water insoluble matter ≤ 0.2% 0.2% Moisture ≤ 0.2% 0.2% Ash ≤ 0.15% 0.2% Water-soluble test Qualified Qualified PH value (4% 25 ℃) 11.4 11.4 [Pharmaceutical Grade ] Name of Item Technical index Premium grade Appearance white crystals Content ≥ 99% Ammonium salt (with NH4Cl meter) ≤ 0.45% Water insoluble matter ≤ 0.2% Moisture ≤ 0.2% Ash ≤ 0.1% Water-soluble test Qualified PH value (4% 25 ℃) 11.4 Heavy Metal ppm ≤10 Arsenic ppm ≤3 The above information is edited by the Chemicalbook of Tian Ye. A preliminary study of ionic liquid solvent for the extraction of uranyl ion Preliminary studies about using imidazole ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate ([C8mim] [PF6]), 1-butyl-3-methylimidazolium hexafluorophosphate ([C4mim] [ PF6]), and quaternary ammonium ionic liquids trioctyl methyl ammonium chloride ([N8881] [Cl]) as diluent, TBP as extracting agent, extraction of uranyl ions from nitric acid medium are done. The results show that the distribution ratio of the extraction of uranium increases as the initial concentration of nitric acid in the aqueous phase increases, quaternary ammonium ionic liquid is slightly better than the imidazole ionic liquids, but worse than the control diluent isooctane .The stripping conditions of guanidine carbonate as the stripping agent is studied . Guanidine carbonate under the experimental conditions can strip the uranyl ion from three kinds of ionic liquid extraction systems quantitatively to solve the re-extraction in ionic liquid extraction of uranyl ion and the circulation usage of ionic liquids. Author: Chutai Wei Qin Li Liu Xinqi Biodistribution CHU Tai-wei QIN Li LIU Xin-qi WANG Xiang-yun Author: Peking University, College of Chemistry and Molecular Engineering, Department of Applied Chemistry, Beijing National Laboratory for Molecular Sciences, Beijing, 100871 Chemical Properties White crystalline powder. 20 ℃ solubility in 100g of the following solution: 42g/100g water, 0.55g/100g of methanol. Practically insoluble in acetone, benzene and ether. Uses Organic synthesis materials and analytical reagents. pH adjusting agents for amino resins, antioxidants, resin stabilizer and guanidine soap, also a grout agent, cement additives, surfactants. In terms of synthetic detergent,it is used as a moisture agent and a synergist. For Zinc, cadmium, manganese weight measurement, it is used as a precipitating agent, it is also used in the separation of alkali metal magnesium. production method Melt double cyanide salts and ammonia to generate guanidine salts (guanidine hydrochloride, guanidine nitrate) at 170-230 ℃ . Then make guanidine salt into an alcohol solution, add soda to free guanidine, absorb carbon dioxide to obtain guanidine carbonate. Chemical Properties white to almost white crystalline powder Uses As a strong organic alkali, organic intermediate, soap and cosmetic products. Uses guanidine carbonate is used to adjust the pH of a formulation. Uses Guanidine Carbonate is used in the cytidine triphosphate injection stabilization. It also acts as a powerful and versatile protein denaturants. Hazard Toxic by ingestion. Purification Methods Crystallise it from MeOH. [Beilstein 3 H 86, 3 I 41, 3 II 72, 3 III 161, 3 IV 152.]   Guanidine carbonate Preparation Products And Raw materials Raw materials CARBON DIOXIDE-->Guanidine hydrochloride-->Guanidine nitrate Preparation Products DPX-T5648-->6-(TERT-BUTYL)PYRIMIDINE-2,4-DIAMINE-->2,5-Diaminopyrimidine-->4-Hydrazino-6-methylpyrimidin-2-amine-->2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE-->Brodimoprim-->5-Chloropyrimidin-2-amine-->2-Amino-1,3,5-triazine-->5-tert-butoxyquinazoline-2,4-diaMine-->3-OXO-3-O-TOLYL-PROPIONIC ACID ETHYL ESTER-->2-Amino-6-methyl-4-pyrimidinol

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Guanidine carbonate Basic information High purity Guanidine carbonate synthesis method Reference quality standards A preliminary study of ionic liquid solvent for the extraction of uranyl ion Chemical Properties Uses production method Product Name: Guanidine carbonate Synonyms: Carbonic acid, compound with guanidine (1:2);Guanidine·carbonic acid;Guanidne carbonate;Guanidinium carbonate, synthesis grade;Carbonicacid,compd.withguanidine(1:1);Carbonicacid,compd.withguanidine(1:2);Guanidonium-carbonat;Iminoureacarbonate CAS: 593-85-1 MF: C2H7N3O3 MW: 121.1 EINECS: 209-813-7 Product Categories: Building Blocks;Chemical Synthesis;Guanidines;Nitrogen Compounds;Nitrogen Compounds;Organic Building Blocks;Pharmaceutical Intermediates;Organic Building Blocks;593-85-1 Mol File: 593-85-1.mol   Guanidine carbonate Chemical Properties Melting point  >300 °C(lit.) density  1.25 storage temp.  Store below +30°C. solubility  450g/l form  Crystalline Powder color  White to almost white PH 11.7 (110g/l, H2O, 20℃) Water Solubility  450 g/L (20 ºC) BRN  3628359 InChIKey KMSRVXJGTIRNNK-UHFFFAOYSA-N CAS DataBase Reference 593-85-1(CAS DataBase Reference) NIST Chemistry Reference Guanidine carbonate(593-85-1) EPA Substance Registry System Guanidine carbonate (2:1) (593-85-1)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38-20/21/22 Safety Statements  26-36-22 WGK Germany  3 RTECS  FG1750000 Autoignition Temperature 530 °C TSCA  Yes HS Code  29252000 Toxicity LD50 orally in Rabbit: 1045 mg/kg MSDS Information Provider Language Guanidine carbonate English ACROS English SigmaAldrich English ALFA English   Guanidine carbonate Usage And Synthesis High purity Guanidine carbonate synthesis method Guanidine carbonate is an extremely versatile organic chemical products, it is mainly used in flame retardants, flocculants, foaming agents, synthetic sulfa drugs, etc. Guanidine carbonate is also used as synthetic detergent builders, high-quality cosmetics raw materials.Synthesis of guanidine carbonate is reported by many literatures [1-3] .The main domestic guanidine carbonate production is that molt dicyandiamide and ammonium chloride to generate guanidine hydrochloride, generate free guanidine under the action of the alkali, and then by the reaction of free guanidine and carbon dioxide to produce guanidine carbonate. this route is easy to generate melamine and its dimers, trimers and other impurities because of the high-temperature melting , and the presence of Cl-, Na + in the system is difficult to completely removed , even if the purity is> 99% of guanidine carbonate, its ash content is still up 0.2%, it is difficult to obtain high purity guanidine carbonate. in this paper, cyanamide as raw materials, reacts with carbon dioxide and ammonia in one step synthesis of guanidine carbonate, also known as ash-free guanidine carbonate, and then purify , to obtain a high purity guanidine carbonate, the reaction equation is as follows: 2NH2CN + CO2 + 2NH3 + H20 → [NH2C (: NH) NH2] 2H2CO3 Author: Zhouzhao Liang Xie Jianwei Zhou Xiaohong Jiang Yongqing Author: Zhouzhao Liang, Xie Jianwei (Research Institute of Zhejiang University of West Branch Quzhou 324006) Zhou Xiaohong, Jiang Yongqing (Institute of Fine Chemicals Group Technology Center Juhua Quzhou 324004) Reference quality standards [Industry Grade ] Name of Item Technical index Premium grade B product Appearance white crystalline white powder Content of ≥ 99% 98% Ammonium ≤ 0.45% 1.0% Water insoluble matter ≤ 0.2% 0.2% Moisture ≤ 0.2% 0.2% Ash ≤ 0.15% 0.2% Water-soluble test Qualified Qualified PH value (4% 25 ℃) 11.4 11.4 [Pharmaceutical Grade ] Name of Item Technical index Premium grade Appearance white crystals Content ≥ 99% Ammonium salt (with NH4Cl meter) ≤ 0.45% Water insoluble matter ≤ 0.2% Moisture ≤ 0.2% Ash ≤ 0.1% Water-soluble test Qualified PH value (4% 25 ℃) 11.4 Heavy Metal ppm ≤10 Arsenic ppm ≤3 The above information is edited by the Chemicalbook of Tian Ye. A preliminary study of ionic liquid solvent for the extraction of uranyl ion Preliminary studies about using imidazole ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate ([C8mim] [PF6]), 1-butyl-3-methylimidazolium hexafluorophosphate ([C4mim] [ PF6]), and quaternary ammonium ionic liquids trioctyl methyl ammonium chloride ([N8881] [Cl]) as diluent, TBP as extracting agent, extraction of uranyl ions from nitric acid medium are done. The results show that the distribution ratio of the extraction of uranium increases as the initial concentration of nitric acid in the aqueous phase increases, quaternary ammonium ionic liquid is slightly better than the imidazole ionic liquids, but worse than the control diluent isooctane .The stripping conditions of guanidine carbonate as the stripping agent is studied . Guanidine carbonate under the experimental conditions can strip the uranyl ion from three kinds of ionic liquid extraction systems quantitatively to solve the re-extraction in ionic liquid extraction of uranyl ion and the circulation usage of ionic liquids. Author: Chutai Wei Qin Li Liu Xinqi Biodistribution CHU Tai-wei QIN Li LIU Xin-qi WANG Xiang-yun Author: Peking University, College of Chemistry and Molecular Engineering, Department of Applied Chemistry, Beijing National Laboratory for Molecular Sciences, Beijing, 100871 Chemical Properties White crystalline powder. 20 ℃ solubility in 100g of the following solution: 42g/100g water, 0.55g/100g of methanol. Practically insoluble in acetone, benzene and ether. Uses Organic synthesis materials and analytical reagents. pH adjusting agents for amino resins, antioxidants, resin stabilizer and guanidine soap, also a grout agent, cement additives, surfactants. In terms of synthetic detergent,it is used as a moisture agent and a synergist. For Zinc, cadmium, manganese weight measurement, it is used as a precipitating agent, it is also used in the separation of alkali metal magnesium. production method Melt double cyanide salts and ammonia to generate guanidine salts (guanidine hydrochloride, guanidine nitrate) at 170-230 ℃ . Then make guanidine salt into an alcohol solution, add soda to free guanidine, absorb carbon dioxide to obtain guanidine carbonate. Chemical Properties white to almost white crystalline powder Uses As a strong organic alkali, organic intermediate, soap and cosmetic products. Uses guanidine carbonate is used to adjust the pH of a formulation. Uses Guanidine Carbonate is used in the cytidine triphosphate injection stabilization. It also acts as a powerful and versatile protein denaturants. Hazard Toxic by ingestion. Purification Methods Crystallise it from MeOH. [Beilstein 3 H 86, 3 I 41, 3 II 72, 3 III 161, 3 IV 152.]   Guanidine carbonate Preparation Products And Raw materials Raw materials CARBON DIOXIDE-->Guanidine hydrochloride-->Guanidine nitrate Preparation Products DPX-T5648-->6-(TERT-BUTYL)PYRIMIDINE-2,4-DIAMINE-->2,5-Diaminopyrimidine-->4-Hydrazino-6-methylpyrimidin-2-amine-->2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE-->Brodimoprim-->5-Chloropyrimidin-2-amine-->2-Amino-1,3,5-triazine-->5-tert-butoxyquinazoline-2,4-diaMine-->3-OXO-3-O-TOLYL-PROPIONIC ACID ETHYL ESTER-->2-Amino-6-methyl-4-pyrimidinol