PRODUCT DETAILS
| L-Histidine hydrochloride monohydrate Basic information |
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| L-Histidine hydrochloride monohydrate Chemical Properties |
| Melting point |
254 °C (dec.)(lit.) |
| alpha |
9.9 º (c=11, 6 N HCl) |
| density |
1.49 g/cm3 |
| vapor pressure |
<1 hPa (20 °C) |
| storage temp. |
Store below +30°C. |
| solubility |
H2O: 100 mg/mL |
| form |
Solid |
| color |
White |
| PH |
3.5-4.5 (100g/l, H2O, 20℃) |
| PH Range |
3 - 4 at 105 g/l at 25 °C |
| optical activity |
[α]20/D +9.5±0.5°, c = 5% in 5 M HCl |
| Water Solubility |
169.9 g/L (20 ºC) |
| Merck |
14,4720 |
| BRN |
4168261 |
| InChIKey |
CMXXUDSWGMGYLZ-XRIGFGBMSA-N |
| CAS DataBase Reference |
5934-29-2(CAS DataBase Reference) |
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| L-Histidine hydrochloride monohydrate Usage And Synthesis |
| Chemical Properties |
white crystals or cryst. or granular powder |
| Uses |
L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. |
| Uses |
L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.
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| Uses |
L-Histidine Hydrochloride Monohydrate can be used as AhR activators to treat gluten-induced gastrointestinal diseases. It can also be used for hair coloring method. |
| General Description |
Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
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| Biochem/physiol Actions |
L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase. |
| Purification Methods |
Crystallise the monohydrochloride from aqueous EtOH or 60% aqueous EtOH (m 259odec). Alternatively dissolve 10g in 50mL of H2O, decolourise with Norite, filter, evaporate it in a vacuum to a syrup, cool to room temperature, add 95% EtOH with stirring until slightly turbid, scratch the sides of the vessel until crystals form, then add slowly 40mL of EtOH and keep at 0o overnight, filter the solid off, wash it several times with EtOH and dry it in a vacuum. [Cox J Biol Chem 78 475 1929, Cox et al. J Biol Chem 81 73 1929, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1972, 2098 1961, Beilstein 25 II 407, 25 III/IV 4346.] |
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| L-Histidine hydrochloride monohydrate Preparation Products And Raw materials |
Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
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