China Biggest Factory Manufacturer Supply D-Pantolactone CAS 599-04-2 CAS NO.599-04-2

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D-(-)-PANTOLACTONE Basic information Product Name: D-(-)-PANTOLACTONE CAS: 599-04-2 MF: C6H10O3 MW: 130.14 EINECS: 209-963-3 Product Categories: Pharmaceutical Intermediates;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals Mol File: 599-04-2.mol   D-(-)-PANTOLACTONE Chemical Properties Melting point  91 °C(lit.) Boiling point  120-122 °C15 mm Hg(lit.) density  1.1066 (rough estimate) refractive index  -50.8 ° (C=2, H2O) Fp  120-122°C/15mm storage temp.  2-8°C solubility  Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly), Water (S pKa 13.12±0.40(Predicted) form  Crystals or Crystalline Powder color  White optical activity [α]25/D 49.8°, c = 2 in H2O Water Solubility  almost transparency Sensitive  Hygroscopic Merck  14,7013 BRN  80957 InChIKey SERHXTVXHNVDKA-BYPYZUCNSA-N CAS DataBase Reference 599-04-2(CAS DataBase Reference) EPA Substance Registry System Pantolactone (599-04-2)   Safety Information Safety Statements  22-24/25 WGK Germany  1 F  3-10 TSCA  Yes HS Code  29322090 MSDS Information Provider Language ACROS English SigmaAldrich English ALFA English   D-(-)-PANTOLACTONE Usage And Synthesis Chemical Properties WHITE CRYSTALLINE POWDER OR CRYSTALS Uses D-(-)-PANTOLACTONE is an important intermediate in the synthesis of pantothenic acid as well as a degradation product of pantothneic acid in the liver. Causes disorientation and hypothermia, and prevents phenamine-induced hyperthermia. Uses D-(-)-Pantolactone is a chiral auxiliary used in many asymmetric synthesis reactions. It can be used as a chiral starting material to synthesize: An insect sex pheromone named 1S,2S,3R-1-acetoxymethyl-2,3,4,4-tetrameth-ylcyclopentane. (-)-Enantiomer of (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, a norsesquiterpene alkaloid. A bicyclic diterpene named isofregenedadiol. General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Purification Methods Recrystallise the lactone from Et2O/pet ether, diisopropyl ether or *C6H6/pet ether and sublime it at 25o/0.0001mm. It hydrolyses readily to the hydroxy-acid and racemises when heated above 145o. The Brucine salt has m 211-212o (from EtOH). [Kuhn & Wieland Chem Ber 73 1134 1940, and Stiller et al. J Am Chem Soc 62 1779 1940, Bental & Tishler J Am Chem Soc 68 1463 1946, Beilstein 18/1 V 22.]   D-(-)-PANTOLACTONE Preparation Products And Raw materials Raw materials Methanol-->Sulfuric acid-->Formaldehyde-->Sodium cyanide-->Isobutyraldehyde-->HYDROGEN CYANIDE Preparation Products Sodium D-pantothenate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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D-(-)-PANTOLACTONE Basic information Product Name: D-(-)-PANTOLACTONE CAS: 599-04-2 MF: C6H10O3 MW: 130.14 EINECS: 209-963-3 Product Categories: Pharmaceutical Intermediates;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals Mol File: 599-04-2.mol   D-(-)-PANTOLACTONE Chemical Properties Melting point  91 °C(lit.) Boiling point  120-122 °C15 mm Hg(lit.) density  1.1066 (rough estimate) refractive index  -50.8 ° (C=2, H2O) Fp  120-122°C/15mm storage temp.  2-8°C solubility  Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly), Water (S pKa 13.12±0.40(Predicted) form  Crystals or Crystalline Powder color  White optical activity [α]25/D 49.8°, c = 2 in H2O Water Solubility  almost transparency Sensitive  Hygroscopic Merck  14,7013 BRN  80957 InChIKey SERHXTVXHNVDKA-BYPYZUCNSA-N CAS DataBase Reference 599-04-2(CAS DataBase Reference) EPA Substance Registry System Pantolactone (599-04-2)   Safety Information Safety Statements  22-24/25 WGK Germany  1 F  3-10 TSCA  Yes HS Code  29322090 MSDS Information Provider Language ACROS English SigmaAldrich English ALFA English   D-(-)-PANTOLACTONE Usage And Synthesis Chemical Properties WHITE CRYSTALLINE POWDER OR CRYSTALS Uses D-(-)-PANTOLACTONE is an important intermediate in the synthesis of pantothenic acid as well as a degradation product of pantothneic acid in the liver. Causes disorientation and hypothermia, and prevents phenamine-induced hyperthermia. Uses D-(-)-Pantolactone is a chiral auxiliary used in many asymmetric synthesis reactions. It can be used as a chiral starting material to synthesize: An insect sex pheromone named 1S,2S,3R-1-acetoxymethyl-2,3,4,4-tetrameth-ylcyclopentane. (-)-Enantiomer of (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, a norsesquiterpene alkaloid. A bicyclic diterpene named isofregenedadiol. General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Purification Methods Recrystallise the lactone from Et2O/pet ether, diisopropyl ether or *C6H6/pet ether and sublime it at 25o/0.0001mm. It hydrolyses readily to the hydroxy-acid and racemises when heated above 145o. The Brucine salt has m 211-212o (from EtOH). [Kuhn & Wieland Chem Ber 73 1134 1940, and Stiller et al. J Am Chem Soc 62 1779 1940, Bental & Tishler J Am Chem Soc 68 1463 1946, Beilstein 18/1 V 22.]   D-(-)-PANTOLACTONE Preparation Products And Raw materials Raw materials Methanol-->Sulfuric acid-->Formaldehyde-->Sodium cyanide-->Isobutyraldehyde-->HYDROGEN CYANIDE Preparation Products Sodium D-pantothenate