China Biggest Manufacturer factory sales Cysteamine/2-AMINOETHANETHIOL CAS 60-23-1 CAS NO.60-23-1

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2-AMINOETHANETHIOL Basic information Product Name: 2-AMINOETHANETHIOL Synonyms: 2-Amino-1-ethanethiol;2-amino-ethanethio;2-Aminoethyl mercaptan;2-aminoethylmercaptan;THIOETHANOLAMINE;2-MERCAPTOETHYLAMINE;2-MERCAPTOETHYLAMINE, POLYMER-BOUND;2-AMINOETHANETHIOL CAS: 60-23-1 MF: C2H7NS MW: 77.15 EINECS: 200-463-0 Product Categories: ZOCOR;Pharmaceutical Intermediates;Amino Acid Library;Building Blocks;Chemical Synthesis;Metabolic Libraries;ANTIOXIDANTS;Antioxidant;Biochemistry;Catalysis and Inorganic Chemistry;Metabolomics;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans;Metal Scavengers;MetalChemical Synthesis;Scavengers;Supported Synthesis Mol File: 60-23-1.mol   2-AMINOETHANETHIOL Chemical Properties Melting point  95°C Boiling point  130 °C density  0.934 (estimate) refractive index  1.5300 (estimate) storage temp.  2-8°C pka 8.35(at 25℃) form  Powder color  White to slightly yellow Merck  14,2779 BRN  635649 Stability: Stable, but may be air-sensitive. Incompatible with strong oxidizing agents. CAS DataBase Reference 60-23-1(CAS DataBase Reference) EPA Substance Registry System Cysteamine (60-23-1)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38 Safety Statements  26-36 RIDADR  3259 WGK Germany  3 RTECS  KJ0175000 F  1-3-10-13-34 HS Code  29309090 Hazardous Substances Data 60-23-1(Hazardous Substances Data) Toxicity LD50 in mice (mg/kg): 625 orally; 250 i.p. (Klayman); (Srivastava, Field) MSDS Information Provider Language SigmaAldrich English   2-AMINOETHANETHIOL Usage And Synthesis Description 2-AMINOETHANETHIOL is the chemical compound with the formula HSCH2CH2NH2. It is the simplest stable aminothiol and a degradation product of the amino acid cysteine. It is often used as the hydrochloride salt, HSCH2CH2NH3Cl. The comparatively high melting point of cysteamine (95-97 °C), indicates that exists in a salt form. Chemical Properties 2-AMINOETHANETHIOL is white powder Uses antihyperlipidemic, HMGCoA reductase inhibitor Uses Scavenges benzyl and allyl halides and ketones. Uses Cysteamine is suitable for use: in the preparation of cysteamine modified gold nanoparticles (AuNP) in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond to enhance in vitro development of porcine oocytes matured and fertilized in vitro in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange as a radioprotector to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content as a scavenger in electrophoretic gels (acetic acid/urea gels) Uses 2-Aminoethanethiol is used in preparation method of fluorescence quenching array sensor based on cadmium telluride quantum dots and application in qualitative discrimination and quantitative analysis of organic acids. Definition 2-AMINOETHANETHIOL is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2. Preparation Cysteamine can also be prepared by the reaction of ethylenimine with hydrogen sulfide. (NHCH2CH2) + H2S → HSCH2CH2NH2. Reactions 2-AMINOETHANETHIOL is used as the hydrochloride salt, as it readily oxidizes to the corresponding disulfide, in the presence of air. The amine portion of the molecule serves as a catalyst for this reaction. 4 HSCH2CH2NH2 + O2 → 2 NH2CH2CH2SSCH2CH2NH2 + 2 H2O. Pharmaceutical Applications Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria. It is also used for treatment of radiation sickness. Cysteamine is used in the body to form the essential biochemical coenzyme A by combining with pantothenate and adenosine triphosphate. In 2008, Raptor Pharmaceuticals started phase II clinical trials testing a delayed release (DR) preparation of cysteamine bitartrate for Huntington's disease. DR Cysteamine is also being investigated as a treatment for cystinosis, Batten disease, and non-alcoholic steatohepatitis. Biochem/physiol Actions Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis. Safety Profile Poison by intravenous, subcutaneous, and intraperitoneal routesModerately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NOx,. Purification Methods It is soluble in H2O giving an alkaline reaction, and it has a disagreeable odour. A likely impurity is the disulfide cystamine which is not soluble in alkaline solution. Under a N2 atmosphere dissolve it in EtOH, evaporate to dryness and wash the white residue with dry pet ether, then sublime it at 0.1mm and store it under N2 at 0-10o in the dark. Its HgCl2 (2:3) complex has m 181-182o (from H2O), and its picrate has m 125-126o. [Mills & Bogert J Am Chem Soc 57 2328 1935, 62 1173 1940, Baddiley & Thain J Chem Soc 800 1952, Shirley Preparation of Organic Intermediates (J. Wiley) Vol 3 189 1951, Barkowski & Hedberg J Am Chem Soc 109 6989 1987, Beilstein 4 IV 1570.]   2-AMINOETHANETHIOL Preparation Products And Raw materials Raw materials Hydrogen Sulfide-->Ethyleneimine Preparation Products Fosthiazate-->Coenzyme A-->4-[[(2-aminoethyl)thio]methyl]-5-methylimidazole-->Thiacloprid-->N-(2-MERCAPTOETHYL)ACETAMIDE-->selenocystamine-->N-Benzylacetoacetamide-->2-METHYLTHIAZOLIDINE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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2-AMINOETHANETHIOL Basic information Product Name: 2-AMINOETHANETHIOL Synonyms: 2-Amino-1-ethanethiol;2-amino-ethanethio;2-Aminoethyl mercaptan;2-aminoethylmercaptan;THIOETHANOLAMINE;2-MERCAPTOETHYLAMINE;2-MERCAPTOETHYLAMINE, POLYMER-BOUND;2-AMINOETHANETHIOL CAS: 60-23-1 MF: C2H7NS MW: 77.15 EINECS: 200-463-0 Product Categories: ZOCOR;Pharmaceutical Intermediates;Amino Acid Library;Building Blocks;Chemical Synthesis;Metabolic Libraries;ANTIOXIDANTS;Antioxidant;Biochemistry;Catalysis and Inorganic Chemistry;Metabolomics;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans;Metal Scavengers;MetalChemical Synthesis;Scavengers;Supported Synthesis Mol File: 60-23-1.mol   2-AMINOETHANETHIOL Chemical Properties Melting point  95°C Boiling point  130 °C density  0.934 (estimate) refractive index  1.5300 (estimate) storage temp.  2-8°C pka 8.35(at 25℃) form  Powder color  White to slightly yellow Merck  14,2779 BRN  635649 Stability: Stable, but may be air-sensitive. Incompatible with strong oxidizing agents. CAS DataBase Reference 60-23-1(CAS DataBase Reference) EPA Substance Registry System Cysteamine (60-23-1)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38 Safety Statements  26-36 RIDADR  3259 WGK Germany  3 RTECS  KJ0175000 F  1-3-10-13-34 HS Code  29309090 Hazardous Substances Data 60-23-1(Hazardous Substances Data) Toxicity LD50 in mice (mg/kg): 625 orally; 250 i.p. (Klayman); (Srivastava, Field) MSDS Information Provider Language SigmaAldrich English   2-AMINOETHANETHIOL Usage And Synthesis Description 2-AMINOETHANETHIOL is the chemical compound with the formula HSCH2CH2NH2. It is the simplest stable aminothiol and a degradation product of the amino acid cysteine. It is often used as the hydrochloride salt, HSCH2CH2NH3Cl. The comparatively high melting point of cysteamine (95-97 °C), indicates that exists in a salt form. Chemical Properties 2-AMINOETHANETHIOL is white powder Uses antihyperlipidemic, HMGCoA reductase inhibitor Uses Scavenges benzyl and allyl halides and ketones. Uses Cysteamine is suitable for use: in the preparation of cysteamine modified gold nanoparticles (AuNP) in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond to enhance in vitro development of porcine oocytes matured and fertilized in vitro in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange as a radioprotector to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content as a scavenger in electrophoretic gels (acetic acid/urea gels) Uses 2-Aminoethanethiol is used in preparation method of fluorescence quenching array sensor based on cadmium telluride quantum dots and application in qualitative discrimination and quantitative analysis of organic acids. Definition 2-AMINOETHANETHIOL is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2. Preparation Cysteamine can also be prepared by the reaction of ethylenimine with hydrogen sulfide. (NHCH2CH2) + H2S → HSCH2CH2NH2. Reactions 2-AMINOETHANETHIOL is used as the hydrochloride salt, as it readily oxidizes to the corresponding disulfide, in the presence of air. The amine portion of the molecule serves as a catalyst for this reaction. 4 HSCH2CH2NH2 + O2 → 2 NH2CH2CH2SSCH2CH2NH2 + 2 H2O. Pharmaceutical Applications Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria. It is also used for treatment of radiation sickness. Cysteamine is used in the body to form the essential biochemical coenzyme A by combining with pantothenate and adenosine triphosphate. In 2008, Raptor Pharmaceuticals started phase II clinical trials testing a delayed release (DR) preparation of cysteamine bitartrate for Huntington's disease. DR Cysteamine is also being investigated as a treatment for cystinosis, Batten disease, and non-alcoholic steatohepatitis. Biochem/physiol Actions Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis. Safety Profile Poison by intravenous, subcutaneous, and intraperitoneal routesModerately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NOx,. Purification Methods It is soluble in H2O giving an alkaline reaction, and it has a disagreeable odour. A likely impurity is the disulfide cystamine which is not soluble in alkaline solution. Under a N2 atmosphere dissolve it in EtOH, evaporate to dryness and wash the white residue with dry pet ether, then sublime it at 0.1mm and store it under N2 at 0-10o in the dark. Its HgCl2 (2:3) complex has m 181-182o (from H2O), and its picrate has m 125-126o. [Mills & Bogert J Am Chem Soc 57 2328 1935, 62 1173 1940, Baddiley & Thain J Chem Soc 800 1952, Shirley Preparation of Organic Intermediates (J. Wiley) Vol 3 189 1951, Barkowski & Hedberg J Am Chem Soc 109 6989 1987, Beilstein 4 IV 1570.]   2-AMINOETHANETHIOL Preparation Products And Raw materials Raw materials Hydrogen Sulfide-->Ethyleneimine Preparation Products Fosthiazate-->Coenzyme A-->4-[[(2-aminoethyl)thio]methyl]-5-methylimidazole-->Thiacloprid-->N-(2-MERCAPTOETHYL)ACETAMIDE-->selenocystamine-->N-Benzylacetoacetamide-->2-METHYLTHIAZOLIDINE