China Largest Factory Manufacturer sales 6-Aminocaproic acid CAS 60-32-2 CAS NO.60-32-2

                                PRODUCT DETAILS       

6-Aminocaproic acid Basic information Description References Product Name: 6-Aminocaproic acid Synonyms: 177 J.D;177 J.D.;177j.d.;177jd;6-amino-hexanoicaci;Acepramin;Acepramine;ACS CAS: 60-32-2 MF: C6H13NO2 MW: 131.17 EINECS: 200-469-3 Product Categories: omega-Aminocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;Amino Acids;Organic acids;Fibrinogen/Thrombin;Pharmaceutical raw materials;AMICAR Mol File: 60-32-2.mol   6-Aminocaproic acid Chemical Properties Melting point  207-209 °C (dec.) (lit.) Boiling point  242.49°C (rough estimate) density  1.042 g/cm3 vapor pressure  <0.1 hPa (20 °C) refractive index  1.4870 (estimate) Fp  207-209°C storage temp.  Store below +30°C. solubility  H2O: 50 mg/mL form  powder pka 4.373(at 25℃) color  white PH 7.0-7.5 (50g/l, H2O, 20℃) Odor Odorless Water Solubility  SOLUBLE Merck  14,432 BRN  906872 InChIKey SLXKOJJOQWFEFD-UHFFFAOYSA-N CAS DataBase Reference 60-32-2(CAS DataBase Reference) NIST Chemistry Reference Hexanoic acid, 6-amino-(60-32-2) EPA Substance Registry System Hexanoic acid, 6-amino- (60-32-2)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  MO6300000 TSCA  Yes HS Code  29224995 Hazardous Substances Data 60-32-2(Hazardous Substances Data) Toxicity LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy) MSDS Information Provider Language 6-Aminohexanoic acid English SigmaAldrich English ACROS English ALFA English   6-Aminocaproic acid Usage And Synthesis Description 6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease. References # # Chemical Properties white crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform. Originator Epsilon,Roche,W. Germany,1962 Uses 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system. Uses Propylparaben Food preservative Uses EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature. Definition ChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion. Application 6-Aminohexanoic acid was used as a biochemical reagent. 6-Aminocaproic acid is used in organic synthesis. As an anti-fibrinolytic agent. Used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is also used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology. 6-Aminocaproic acid works by inhibiting the fibrinolytic system. Mainly used for hemorrhage caused by elevated plasmin activity, such as obstetrics and gynecology hemorrhage, hemorrhage after prostate, liver, pancreas, lung and other visceral operations. Early intraoperative medication or preoperative medication can reduce intraoperative oozing and reduce blood transfusion volume. 6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect. Preparation Synthesis of 6-aminocaproic acid: obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide. Manufacturing Process 5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired. Brand name Amicar (Xanodyne). Therapeutic Function Antifibrinolytic General Description Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B. Mechanism of action Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding. Safety Profile Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,. Chemical Synthesis Aminocaproic acid (24.4.1) is synthesized by hydrolyzing ε -caprolactam at high temperature. Veterinary Drugs and Treatments Aminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.   6-Aminocaproic acid Preparation Products And Raw materials Raw materials Ammonium hydroxide-->Caprolactam-->AMBERLITE IR-120-->Water Preparation Products Gabexate mesylate-->Capobenic acid-->N-tert-Butoxycarbonyl-1,6-hexanediamine-->(5-Carboxypentyl)(triphenyl)phosphonium bromide-->Decanoyl chloride-->NERIDRONATE SODIUM HYDRATE-->LC-LC(+)-Biotin-->6-Azido-hexanoic acid-->1,8-diazacyclotetradecane-2,9-dione-->METHYL 6-AMINOCAPROATE HYDROCHLORIDE-->RGFP 109-->(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID

                                                                About Our Group

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                      Our Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

6-Aminocaproic acid Basic information Description References Product Name: 6-Aminocaproic acid Synonyms: 177 J.D;177 J.D.;177j.d.;177jd;6-amino-hexanoicaci;Acepramin;Acepramine;ACS CAS: 60-32-2 MF: C6H13NO2 MW: 131.17 EINECS: 200-469-3 Product Categories: omega-Aminocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;Amino Acids;Organic acids;Fibrinogen/Thrombin;Pharmaceutical raw materials;AMICAR Mol File: 60-32-2.mol   6-Aminocaproic acid Chemical Properties Melting point  207-209 °C (dec.) (lit.) Boiling point  242.49°C (rough estimate) density  1.042 g/cm3 vapor pressure  <0.1 hPa (20 °C) refractive index  1.4870 (estimate) Fp  207-209°C storage temp.  Store below +30°C. solubility  H2O: 50 mg/mL form  powder pka 4.373(at 25℃) color  white PH 7.0-7.5 (50g/l, H2O, 20℃) Odor Odorless Water Solubility  SOLUBLE Merck  14,432 BRN  906872 InChIKey SLXKOJJOQWFEFD-UHFFFAOYSA-N CAS DataBase Reference 60-32-2(CAS DataBase Reference) NIST Chemistry Reference Hexanoic acid, 6-amino-(60-32-2) EPA Substance Registry System Hexanoic acid, 6-amino- (60-32-2)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  MO6300000 TSCA  Yes HS Code  29224995 Hazardous Substances Data 60-32-2(Hazardous Substances Data) Toxicity LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy) MSDS Information Provider Language 6-Aminohexanoic acid English SigmaAldrich English ACROS English ALFA English   6-Aminocaproic acid Usage And Synthesis Description 6-aminocaproic acid (Brand name: Amicar) is a kind of synthetic derivative of lysine. Since it is a analogue of amino acid lysine, it can act as the inhibitor for enzymes that need to bind to that particular lysine residue, e.g. the proteolytic enzyme such as plasmin, which is responsible for fibrinolysis. Therefore, it has anti-fibrinolytic activity. It also competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin. Based on this property, it can be used for the treatment of acute bleeding due to elevated fibrinolytic activity in many clinical situations. It can also indicated by FDA for the prevention of recurrent hemorrhage in patients of traumatic hyphema. It may also act as a prophylactic against the vascular disease due to its inhibitory effect on the formation of lipoprotein which is the risk factor of vascular disease. References # # Chemical Properties white crystalline powder. Leaf crystals were obtained from ether. Odorless, bitter taste. Melting point 202 ~ 207 ℃ (decomposition). Soluble in water, slightly soluble in methanol, insoluble in ethanol, ether and chloroform. Originator Epsilon,Roche,W. Germany,1962 Uses 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system. Uses Propylparaben Food preservative Uses EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature. Definition ChEBI: 6-aminohexanoic acid is an epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. It has a role as an antifibrinolytic drug, a hematologic agent and a metabolite. It is an epsilon-amino acid and an omega-amino fatty acid. It derives from a hexanoic acid. It is a conjugate acid of a 6-aminohexanoate. It is a tautomer of a 6-aminohexanoic acid zwitterion. Application 6-Aminohexanoic acid was used as a biochemical reagent. 6-Aminocaproic acid is used in organic synthesis. As an anti-fibrinolytic agent. Used as a hemostatic agent. 6-aminocaproic acid has a significant effect on some severe bleeding caused by increased fibrinolytic activity. It is suitable for oozing or local bleeding during various surgical operations. 6-aminocaproic acid is also used for hemoptysis, gastrointestinal bleeding and bleeding disorders in obstetrics and gynecology. 6-Aminocaproic acid works by inhibiting the fibrinolytic system. Mainly used for hemorrhage caused by elevated plasmin activity, such as obstetrics and gynecology hemorrhage, hemorrhage after prostate, liver, pancreas, lung and other visceral operations. Early intraoperative medication or preoperative medication can reduce intraoperative oozing and reduce blood transfusion volume. 6-Aminocaproic acid is an anti-fibrinolytic drug with a similar chemical structure to lysine. It can qualitatively inhibit the binding of plasminogen to fibrin and prevent its activation, thereby inhibiting fibrinolysis and achieving hemostasis. Aminocaproic acid is a monoaminocarboxylic acid, which can inhibit the conversion of plasminogen into plasmin and its binding to fibrin. For severe bleeding caused by hyperfibrinolysis caused by increased activation of plasminogen, can have therapeutic effect. Preparation Synthesis of 6-aminocaproic acid: obtained by hydrolysis of 6-(N-benzoylamino)capronitrile in the presence of hydrochloric acid, or by hydrolysis of caprolactam in the presence of hydrochloric acid, and then treated with ammonium hydroxide. Manufacturing Process 5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired. Brand name Amicar (Xanodyne). Therapeutic Function Antifibrinolytic General Description Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B. Mechanism of action Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding. Safety Profile Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,. Chemical Synthesis Aminocaproic acid (24.4.1) is synthesized by hydrolyzing ε -caprolactam at high temperature. Veterinary Drugs and Treatments Aminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.   6-Aminocaproic acid Preparation Products And Raw materials Raw materials Ammonium hydroxide-->Caprolactam-->AMBERLITE IR-120-->Water Preparation Products Gabexate mesylate-->Capobenic acid-->N-tert-Butoxycarbonyl-1,6-hexanediamine-->(5-Carboxypentyl)(triphenyl)phosphonium bromide-->Decanoyl chloride-->NERIDRONATE SODIUM HYDRATE-->LC-LC(+)-Biotin-->6-Azido-hexanoic acid-->1,8-diazacyclotetradecane-2,9-dione-->METHYL 6-AMINOCAPROATE HYDROCHLORIDE-->RGFP 109-->(+)-BIOTIN-EPSILON-AMINOCAPROIC ACID