China Largest Manufacturer factory sales Phloretin CAS 60-82-2 CAS NO.60-82-2

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Phloretin Basic information Product Name: Phloretin Synonyms: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one;2,4,6-Trihydroxy-B-(4-Hydroxyphenyl)Propiophenone;Phloretin,98%;β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone;PHLORETIN(RG);1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-;Dihydronaringenin;Floretin CAS: 60-82-2 MF: C15H14O5 MW: 274.27 EINECS: 200-488-7 Product Categories: chemical reagent;pharmaceutical intermediate;Chalcones;All Inhibitors;phytochemical;reference standards from Chinese medicinal herbs (TCM).;Inhibitors;Protein Kinase Inhibitors and Activators;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;standardized herbal extract Mol File: 60-82-2.mol   Phloretin Chemical Properties Melting point  ~260 °C Boiling point  337.26°C (rough estimate) density  1.1827 (rough estimate) FEMA  4390 | 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE refractive index  1.573-1.575 storage temp.  2-8°C solubility  Acetonitrile (Slightly), Methanol (Slightly) pka 7.16±0.40(Predicted) form  Powder color  White to beige Water Solubility  soluble Merck  14,7326 JECFA Number 2022 BRN  1887240 InChIKey VGEREEWJJVICBM-UHFFFAOYSA-N CAS DataBase Reference 60-82-2(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  37/39-26-36 WGK Germany  3 F  3-10 HazardClass  IRRITANT HS Code  29145090 MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   Phloretin Usage And Synthesis Chemical Properties Crystalline Solid Chemical Properties White to pale yellow solid. Uses Phloretin has been used: to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro Uses The aglucon of Phlorizin. A glucose transport inhibitor. Also inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts. Uses antidiabetic, inhibits glucose transport Uses antioxidant cosmetic use Uses A calcium channel protein inhibitor. Definition ChEBI: A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'. General Description Phloretin is a dihydrochalcone flavonoid with antioxidant activity usually found in apples and apple-derived products. It is extensively used for peroxynitrite scavenging and the inhibition of lipid peroxidation. Biochem/physiol Actions Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules. Purification Methods Crystallise phloretin from aqueous EtOH. [Zemplen & Bognár Chem Ber 75 1040 1942, Zemplén Chem Ber 76 386 1943, Beilstein 8 IV 3518.]   Phloretin Preparation Products And Raw materials Preparation Products UDP

                                                                         About US 
Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Phloretin Basic information Product Name: Phloretin Synonyms: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one;2,4,6-Trihydroxy-B-(4-Hydroxyphenyl)Propiophenone;Phloretin,98%;β-(4-hydroxyphenyl)-2,4,6-trihydroxypropiophenone;PHLORETIN(RG);1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-;Dihydronaringenin;Floretin CAS: 60-82-2 MF: C15H14O5 MW: 274.27 EINECS: 200-488-7 Product Categories: chemical reagent;pharmaceutical intermediate;Chalcones;All Inhibitors;phytochemical;reference standards from Chinese medicinal herbs (TCM).;Inhibitors;Protein Kinase Inhibitors and Activators;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;standardized herbal extract Mol File: 60-82-2.mol   Phloretin Chemical Properties Melting point  ~260 °C Boiling point  337.26°C (rough estimate) density  1.1827 (rough estimate) FEMA  4390 | 3-(4-HYDROXYPHENYL)-1-(2,4,6-TRIHYDROXYPHENYL)PROPAN-1-ONE refractive index  1.573-1.575 storage temp.  2-8°C solubility  Acetonitrile (Slightly), Methanol (Slightly) pka 7.16±0.40(Predicted) form  Powder color  White to beige Water Solubility  soluble Merck  14,7326 JECFA Number 2022 BRN  1887240 InChIKey VGEREEWJJVICBM-UHFFFAOYSA-N CAS DataBase Reference 60-82-2(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  37/39-26-36 WGK Germany  3 F  3-10 HazardClass  IRRITANT HS Code  29145090 MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   Phloretin Usage And Synthesis Chemical Properties Crystalline Solid Chemical Properties White to pale yellow solid. Uses Phloretin has been used: to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro Uses The aglucon of Phlorizin. A glucose transport inhibitor. Also inhibits protein kinase C and has been shown to inhibit the entry of five enveloped viruses into human fibroblasts. Uses antidiabetic, inhibits glucose transport Uses antioxidant cosmetic use Uses A calcium channel protein inhibitor. Definition ChEBI: A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'. General Description Phloretin is a dihydrochalcone flavonoid with antioxidant activity usually found in apples and apple-derived products. It is extensively used for peroxynitrite scavenging and the inhibition of lipid peroxidation. Biochem/physiol Actions Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules. Purification Methods Crystallise phloretin from aqueous EtOH. [Zemplen & Bognár Chem Ber 75 1040 1942, Zemplén Chem Ber 76 386 1943, Beilstein 8 IV 3518.]   Phloretin Preparation Products And Raw materials Preparation Products UDP