China Biggest Manufacturer factory sales GLYCINE HCL CAS 6000-43-7 CAS NO.6000-43-7

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Glycine hydrochloride Basic information Product Name: Glycine hydrochloride Synonyms: h-gly-oh.hcl;GLYCINE HYDROCHLORIDE SOLUTION;Aminoaceticacid.HCl=H-Gly-OH.HCl;Glycinehydrochloride,98%;Glycine hydrochloride, BR,99%;Glycocol hydrochloride;Glycine solution hydrochloride;Glycine hydrochloride,99% CAS: 6000-43-7 MF: C2H6ClNO2 MW: 111.53 EINECS: 227-841-8 Product Categories: food ingredients;Alphabetic;Amino Acids, Peptides and Proteins;Amino AcidsAnalytical Standards;G;Life Sciences Standards;alpha-Amino Acids;Amino Acids;Biochemistry;omega-Aminocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides Mol File: 6000-43-7.mol   Glycine hydrochloride Chemical Properties Melting point  176-180 °C(lit.) storage temp.  2-8°C form  Crystalline Powder color  White to almost white Water Solubility  SLIGHTLY SOLUBLE Sensitive  Hygroscopic Merck  14,4491 BRN  3909617 CAS DataBase Reference 6000-43-7(CAS DataBase Reference) EPA Substance Registry System Glycine, hydrochloride (6000-43-7)   Safety Information Risk Statements  22 Safety Statements  24/25-44 RIDADR  UN 1789 8/PG 3 WGK Germany  2 RTECS  MC0560000 F  10 TSCA  Yes HS Code  29224999 MSDS Information Provider Language Glycine hydrochloride English SigmaAldrich English ACROS English ALFA English   Glycine hydrochloride Usage And Synthesis Chemical Properties white crystals or crystalline powder Uses Glycine hydrochloride is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.Glycine Hydrochloride is commonly used in buffer solutions, in electrophoresis, and preparative chromatography. Application Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues. Glycine hydrochloride has been used: in the preparation of glycine-HCl buffer to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies to regenerate the sensor to elute the bound C-reactive protein (CRP) Definition Glycine hydrochloride is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. Preparation Glycine hydrochloride can be prepared by the action of hydrochloric acid on hippuric acid,aminoacetonitrile,methyleneaminoacetonitrile, and on ethyl phthaliminoacetate. Aniline has been recommended for its conversion into free glycine. Glycine can also be prepared by the interaction of chloroacetic acid and ammonia; by the hydrolysis of methyleneaminoacetonitrile by successive treatments with barium hydroxide and sulfuric acid; and by the hydrolysis of aminoacetonitrile by means of barium hydroxide. A thorough study has been reported for its preparation in improved yields by the sulfuric acid hydrolysis of aminoacetonitrile, and in satisfactory yields from chloroacetic acid and ammonia. Other methods of preparation include the reduction of cyanoformic esters, a modified Curtius degradation of ethyl cyanoacetate, and the hydrolysis of the neck ligaments of cattle. synthesis of Glycine hydrochloride Biochem/physiol Actions Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain. Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia and reperfusion. Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors. Purification Methods Crystallise the salt from absolute EtOH or 80% EtOH. Monoglycine hydrochloride has m 176-177o, and diglycine monohydrochloride has m 187o. [Frost J Am Chem Soc 64 1286 1942, Beilstein 4 III 1111, 4 IV 2353.]   Glycine hydrochloride Preparation Products And Raw materials Raw materials 2-(2,2,2-TrichloroacetaMido)acetic acid-->isonitroso--->(2,2,2-TRIFLUORO-ACETYLAMINO)-ACETIC ACID ETHYL ESTER-->N-(Methoxycarbonyl)glycine Methyl Ester-->L-Proline hydrochloride-->TRIS hydrochloride-->Hydrochloric acid-->L-Isoleucine hydrochloride-->Benzoic acid-->Glycine-->Hippuric acid-->Diethyl acetamidomalonate Preparation Products 5-AMINO-2-FLUOROPYRIMIDINE-->5-AMINO-PYRIMIDINE-2-CARBOXYLIC ACID-->2,5-OXAZOLIDINEDIONE-->Phenylacetic acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Glycine hydrochloride Basic information Product Name: Glycine hydrochloride Synonyms: h-gly-oh.hcl;GLYCINE HYDROCHLORIDE SOLUTION;Aminoaceticacid.HCl=H-Gly-OH.HCl;Glycinehydrochloride,98%;Glycine hydrochloride, BR,99%;Glycocol hydrochloride;Glycine solution hydrochloride;Glycine hydrochloride,99% CAS: 6000-43-7 MF: C2H6ClNO2 MW: 111.53 EINECS: 227-841-8 Product Categories: food ingredients;Alphabetic;Amino Acids, Peptides and Proteins;Amino AcidsAnalytical Standards;G;Life Sciences Standards;alpha-Amino Acids;Amino Acids;Biochemistry;omega-Aminocarboxylic Acids;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides Mol File: 6000-43-7.mol   Glycine hydrochloride Chemical Properties Melting point  176-180 °C(lit.) storage temp.  2-8°C form  Crystalline Powder color  White to almost white Water Solubility  SLIGHTLY SOLUBLE Sensitive  Hygroscopic Merck  14,4491 BRN  3909617 CAS DataBase Reference 6000-43-7(CAS DataBase Reference) EPA Substance Registry System Glycine, hydrochloride (6000-43-7)   Safety Information Risk Statements  22 Safety Statements  24/25-44 RIDADR  UN 1789 8/PG 3 WGK Germany  2 RTECS  MC0560000 F  10 TSCA  Yes HS Code  29224999 MSDS Information Provider Language Glycine hydrochloride English SigmaAldrich English ACROS English ALFA English   Glycine hydrochloride Usage And Synthesis Chemical Properties white crystals or crystalline powder Uses Glycine hydrochloride is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.Glycine Hydrochloride is commonly used in buffer solutions, in electrophoresis, and preparative chromatography. Application Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues. Glycine hydrochloride has been used: in the preparation of glycine-HCl buffer to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies to regenerate the sensor to elute the bound C-reactive protein (CRP) Definition Glycine hydrochloride is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. Preparation Glycine hydrochloride can be prepared by the action of hydrochloric acid on hippuric acid,aminoacetonitrile,methyleneaminoacetonitrile, and on ethyl phthaliminoacetate. Aniline has been recommended for its conversion into free glycine. Glycine can also be prepared by the interaction of chloroacetic acid and ammonia; by the hydrolysis of methyleneaminoacetonitrile by successive treatments with barium hydroxide and sulfuric acid; and by the hydrolysis of aminoacetonitrile by means of barium hydroxide. A thorough study has been reported for its preparation in improved yields by the sulfuric acid hydrolysis of aminoacetonitrile, and in satisfactory yields from chloroacetic acid and ammonia. Other methods of preparation include the reduction of cyanoformic esters, a modified Curtius degradation of ethyl cyanoacetate, and the hydrolysis of the neck ligaments of cattle. synthesis of Glycine hydrochloride Biochem/physiol Actions Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain. Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia and reperfusion. Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors. Purification Methods Crystallise the salt from absolute EtOH or 80% EtOH. Monoglycine hydrochloride has m 176-177o, and diglycine monohydrochloride has m 187o. [Frost J Am Chem Soc 64 1286 1942, Beilstein 4 III 1111, 4 IV 2353.]   Glycine hydrochloride Preparation Products And Raw materials Raw materials 2-(2,2,2-TrichloroacetaMido)acetic acid-->isonitroso--->(2,2,2-TRIFLUORO-ACETYLAMINO)-ACETIC ACID ETHYL ESTER-->N-(Methoxycarbonyl)glycine Methyl Ester-->L-Proline hydrochloride-->TRIS hydrochloride-->Hydrochloric acid-->L-Isoleucine hydrochloride-->Benzoic acid-->Glycine-->Hippuric acid-->Diethyl acetamidomalonate Preparation Products 5-AMINO-2-FLUOROPYRIMIDINE-->5-AMINO-PYRIMIDINE-2-CARBOXYLIC ACID-->2,5-OXAZOLIDINEDIONE-->Phenylacetic acid