China Biggest Manufacturer factory sales N-Hydroxysuccinimide CAS 6066-82-6 CAS NO.6066-82-6

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N-Hydroxysuccinimide Basic information Product Name: N-Hydroxysuccinimide Synonyms: N-HYDROXY-2,5-PYRROLIDINEDIONE;NHS;N-HYDROXYSUCCINIMDE;N-HYDROXYSUCCINIMIDE;N-HYDROXYSUCCINIMIDE POLYMER-BOUND;NHS N-HYDROXYSUCCINIMIDE,;NHS OR HONSU;HOSu~1-Hydroxy-2,5-pyrrolidinedione CAS: 6066-82-6 MF: C4H5NO3 MW: 115.09 EINECS: 228-001-3 Product Categories: Zero-Length Crosslinker;heteroXlink;Coupling ReagentsSynthetic Reagents;Coupling;Others;APIS;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;Peptide Synthesis;Supported Reagents;Supported Synthesis;Peptide coupling agents;Medical Intermediates;Heterocycles;Other Reagents;Miscellaneous Reagents;Synthetic Organic Chemistry Mol File: 6066-82-6.mol   N-Hydroxysuccinimide Chemical Properties Melting point  95-98 °C(lit.) Boiling point  215.33°C (rough estimate) density  1.4769 (rough estimate) refractive index  1.4080 (estimate) storage temp.  Store at +2°C to +8°C. solubility  DMSO (Soluble), Methanol (Slightly) form  Liquid or Solid pka 7.81±0.20(Predicted) color  Clear yellow-brown to brown PH 5-7 (50g/l, H2O, 20℃) Water Solubility  SOLUBLE Sensitive  Hygroscopic BRN  113913 Stability: Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. InChIKey NQTADLQHYWFPDB-UHFFFAOYSA-N CAS DataBase Reference 6066-82-6(CAS DataBase Reference) NIST Chemistry Reference N-hydroxylsuccinimide(6066-82-6) EPA Substance Registry System 2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-26-36 WGK Germany  3 Hazard Note  Irritant TSCA  Yes HS Code  29251995 MSDS Information Provider Language 1-Hydroxy-2,5-pyrrolidinedione English SigmaAldrich English ACROS English ALFA English   N-Hydroxysuccinimide Usage And Synthesis Description N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers. N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source). Chemical Properties White to pale yellow Uses Reagent for preparation of active esters of amino acids. Uses N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide. Uses N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings. Application N-Hydroxysuccinimide has been used in the synthesis of intermediates such as: N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate 4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester N-succinimidyl 3-iodobenzoate It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens. Additive used in the carbodiimide method for improved amidations and peptide couplings. N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid. Purification Methods Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]   N-Hydroxysuccinimide Preparation Products And Raw materials Raw materials Hydroxylamine hydrochloride-->Succinic anhydride-->NSC81536-->estradiol-3-sulfate-->1-Pyrrolidinecarboxylic acid, 2,5-dioxo-, 1,1-dimethylethyl ester-->1-Hydroxypiperidine-2,6-dione-->N-HYDROXYSUCCINIMIDYL-4-AZIDOBENZOATE-->N,N'-Disuccinimidyl carbonate-->N-(3-aminopropyl)benzamide-->BZ-OSU-->Girard's Reagent T-->N-Succinimidyl 3-maleimidopropionate-->2-METHYLBUTYLAMINE Preparation Products Enalapril-->Imidapril-->N-ACRYLOXYSUCCINIMIDE-->Arbekacin-->Aspoxicillin-->GUSPERIMUS-->Cy5

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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N-Hydroxysuccinimide Basic information Product Name: N-Hydroxysuccinimide Synonyms: N-HYDROXY-2,5-PYRROLIDINEDIONE;NHS;N-HYDROXYSUCCINIMDE;N-HYDROXYSUCCINIMIDE;N-HYDROXYSUCCINIMIDE POLYMER-BOUND;NHS N-HYDROXYSUCCINIMIDE,;NHS OR HONSU;HOSu~1-Hydroxy-2,5-pyrrolidinedione CAS: 6066-82-6 MF: C4H5NO3 MW: 115.09 EINECS: 228-001-3 Product Categories: Zero-Length Crosslinker;heteroXlink;Coupling ReagentsSynthetic Reagents;Coupling;Others;APIS;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;Peptide Synthesis;Supported Reagents;Supported Synthesis;Peptide coupling agents;Medical Intermediates;Heterocycles;Other Reagents;Miscellaneous Reagents;Synthetic Organic Chemistry Mol File: 6066-82-6.mol   N-Hydroxysuccinimide Chemical Properties Melting point  95-98 °C(lit.) Boiling point  215.33°C (rough estimate) density  1.4769 (rough estimate) refractive index  1.4080 (estimate) storage temp.  Store at +2°C to +8°C. solubility  DMSO (Soluble), Methanol (Slightly) form  Liquid or Solid pka 7.81±0.20(Predicted) color  Clear yellow-brown to brown PH 5-7 (50g/l, H2O, 20℃) Water Solubility  SOLUBLE Sensitive  Hygroscopic BRN  113913 Stability: Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. InChIKey NQTADLQHYWFPDB-UHFFFAOYSA-N CAS DataBase Reference 6066-82-6(CAS DataBase Reference) NIST Chemistry Reference N-hydroxylsuccinimide(6066-82-6) EPA Substance Registry System 2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-26-36 WGK Germany  3 Hazard Note  Irritant TSCA  Yes HS Code  29251995 MSDS Information Provider Language 1-Hydroxy-2,5-pyrrolidinedione English SigmaAldrich English ACROS English ALFA English   N-Hydroxysuccinimide Usage And Synthesis Description N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers. N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source). Chemical Properties White to pale yellow Uses Reagent for preparation of active esters of amino acids. Uses N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide. Uses N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings. Application N-Hydroxysuccinimide has been used in the synthesis of intermediates such as: N-succinimidyl 3-(di-tert-butylfluorosilyl)benzoate 4-[2,2-bis[(p-tolylsulfonyl)-methyl] acetyl]benzoic acid-NHS ester N-succinimidyl 3-iodobenzoate It has also been used in a protocol for the surface modification of microchannels of a microfluidic-integrated surface plasmon resonance (SPR) platform for the detection and quantification of bacterial pathogens. Additive used in the carbodiimide method for improved amidations and peptide couplings. N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid. Purification Methods Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]   N-Hydroxysuccinimide Preparation Products And Raw materials Raw materials Hydroxylamine hydrochloride-->Succinic anhydride-->NSC81536-->estradiol-3-sulfate-->1-Pyrrolidinecarboxylic acid, 2,5-dioxo-, 1,1-dimethylethyl ester-->1-Hydroxypiperidine-2,6-dione-->N-HYDROXYSUCCINIMIDYL-4-AZIDOBENZOATE-->N,N'-Disuccinimidyl carbonate-->N-(3-aminopropyl)benzamide-->BZ-OSU-->Girard's Reagent T-->N-Succinimidyl 3-maleimidopropionate-->2-METHYLBUTYLAMINE Preparation Products Enalapril-->Imidapril-->N-ACRYLOXYSUCCINIMIDE-->Arbekacin-->Aspoxicillin-->GUSPERIMUS-->Cy5