China Largest Manufacturer factory Supply Triazol-3-amine CAS 61-82-5 CAS NO.61-82-5

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Triazol-3-amine Basic information Product Name: Triazol-3-amine Synonyms: Amino-s-triazole;AMINOTRIAZOLE;AMIZOLE;AMIZOL(R);AMITROL;AMITROLE;AMITROLE(R);amino-1,2,4-triazole CAS: 61-82-5 MF: C2H4N4 MW: 84.08 EINECS: 200-521-5 Product Categories: ATA;3-Amino-1,2,4-Triazole;AM to AQ;A;Alphabetic;Organic chemical, pesticide;Heterocycles;Organics;Estradiol, etc. (Environmental Endocrine Disruptors);Analytical Chemistry;Environmental Endocrine Disruptors;Agro-Products Mol File: 61-82-5.mol   Triazol-3-amine Chemical Properties Melting point  150-153 °C(lit.) Boiling point  144.35°C (rough estimate) density  1.138 vapor pressure  <0.1 hPa (20 °C) refractive index  1.6260 (estimate) storage temp.  Store below +30°C. solubility  280g/l form  Powder or Flakes pka 11.14±0.20(Predicted) color  White to off-white or yellow PH 6.4-7.4 (100g/l, H2O, 20℃) Water Solubility  280 g/L (20 ºC) Merck  14,489 BRN  107687 Exposure limits NIOSH REL: TWA 0.2 mg/m3; ACGIH TLV: TWA 0.2 mg/m3. Stability: Stable. Incompatible with iron, copper, aluminium, acids, alkalies, strong oxidizing agents, acid chlorides, acid anhydrides. Forms chelates with some metals. Moisture sensitive. CAS DataBase Reference 61-82-5(CAS DataBase Reference) NIST Chemistry Reference 3-Amino-s-triazole(61-82-5) IARC 3 (Vol. 79, Sup 7) 2001 EPA Substance Registry System Amitrole (61-82-5)   Safety Information Hazard Codes  Xn,N,T Risk Statements  48/22-51/53-63-40-61 Safety Statements  13-36/37-61-45-53 RIDADR  UN 3077 9/PG 3 WGK Germany  2 RTECS  XZ3850000 Autoignition Temperature >225 °C TSCA  Yes HazardClass  9 PackingGroup  III HS Code  29339990 Hazardous Substances Data 61-82-5(Hazardous Substances Data) Toxicity LD50 in mice, rats (g/kg): 14.7, 25.0 orally (Krller) MSDS Information Provider Language Amino-s-triazole English SigmaAldrich English ACROS English ALFA English   Triazol-3-amine Usage And Synthesis Chemical Properties white powder or crystals Chemical Properties Amitrole is a colorless to off-white crystalline solid or white powder. Odorless when pure. Uses Nonselective, foliage-applied, systemic, triazole herbicide used in uncropped land and orchards to control certain grasses and to kill annual and perennial grasses and weeds. It is also effective on poison ivy, poison oak and aquatic weeds Uses catalase inhibitor Uses Herbicide; plant regulator. Definition A powerful plant growth suppressant and cotton defoliant that is readily absorbed by leaves and roots. It inhibits many aspects of growth and differentiation including cell division in the primary root meristems in some plants. Production Methods Amitrole is synthesized by condensing formic acid with aminoguanidine and can be purified by recrystallization from methanol. General Description Odorless white crystals or white powder. Bitter taste. Melting point 147-159°C. Sublimes undecomposed at reduced pressure. Used as a post-emergence herbicide. Air & Water Reactions Water soluble. Aqueous solutions are neutral. Dust may form an explosive mixture in air. Reactivity Profile Triazol-3-amine is a triazole derivative. The triazoles are a group that contain several derivatives that are highly explosive materials. They are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. Triazol-3-amine forms chelates with some metals. Triazol-3-amine is corrosive to iron, copper and aluminum. Forms salts with most acids and alkalis. Triazol-3-amine is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides . Hazard Toxic; carcinogen. Health Hazard Amitrole has low acute toxicity; in experimental animal studies subchronic exposures were associated with changes in the thyroid and chronic exposures were carcinogenic. Intentional ingestion of a mixture that contained 20 mg/kg amitrole did not cause any signs of intoxication.1 In one reported case study, inhalation of a large amount of amitrolecontaining herbicide was associated with acute toxic reaction of the lungs.2 Lung injury was thought to be secondary to direct toxic damage to the alveolar lining cells. The remarkable lack of any other reports describing pulmonary toxicity of this herbicide was noted, in addition to the presence of other chemicals in the herbicide solution. Fire Hazard Literature sources indicate that Triazol-3-amine is non-combustible. Agricultural Uses Herbicide, Plant growth regulator: A non-food use herbicide for control of grasses, woody plants and broad-leaf weeds on hard surface and in areas where crops are not normally grown. Trade name AMITRIL®; ATLAZIN®; ATLAZINE® FLOWABLE; AT®; 3-AT®; AT-90®; ATRAFLOW PLUS®; AZAPLANT®; AZAPLANT KOMBI®; AZOLAN®; AZOLE®; BOROFLOW® A/ATA; CAMPAPRIM® A 1544; CDA SIMFLOW PLUS®; CHIPMAN® PATH; CYTROLE®; DIUROL® AMITROLE; DOMATOL®; ELMASIL®; EMISOL®; FARMCO®; HERBAZIN PLUS SC®; HERBICIDE® TOTAL; MASCOT HIGHWAY®; MSS AMINOTRIAZOLE®; MSS SIMAZINE®; ORGA-414®; RADOXONE® TL; RAMIZOL®; RASSAPRON®; SIMAZOL®; SIMFLOW PLUS®; SOLUTION CNCENTREE T271®; SYNCHEMICALS® TOTAL WEED KILLER; SYNTOX®; TORAPRON®; VOROX®; WEEDAR®; WEEDAZIN®; WEEDAZOL TL ®; WEEDOCLOR® Biochem/physiol Actions BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors.Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments. Safety Profile Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. An herbicide and plant growth regulator Potential Exposure A potential danger to those involved in the manufacture, formulation, and application of this postemergence herbicide, which is now limited to noncrop applications as a herbicide and plant growth regulator. Some triazoles have been used as rubber components. Carcinogenicity Amitrole is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. Environmental Fate Soil. When radiolabeled amitrole-5-14C was incubated in a Hagerstown silty clay loam, 50 and 70% of the applied amount evolved as 14CO2 after 3 and 20 days, respectively. In autoclaved soil, however, no 14CO2 was detected. The chemical degradation in soil was probably via hydroxyl radicals (Kaufman et al., 1968). The average persistence in soils is 2–4 weeks (Hartley and Kidd, 1987) Plant.Amitrole is transformed in plants to form the conjugate β-(3-amino-1,2,4-triazol- 1-yl)-α-alanine (Humburg et al., 1989) and/or 3-(3-amino-s-triazole-1-yl)-2-aminopropionic acid (Duke et al., 1991). Amitrole is metabolized in Canada thistl Surface Water. In pond water, adsorption to suspended sediments was an important process. The initial half-life was reported to be no more than 68 days. After 120 days, 20% of the applied amount remained (Grzenda et al., 1966). The biodegradation Photolytic. Direct photolysis of amitrole is not expected to occur since the herbicide shows little or no absorption greater than 295 nm (Gore et al., 1971) Chemical/Physical. Reacts with acids and bases forming soluble salts (Hartley and Kidd, 1987). Emits toxic fumes of nitrogen oxides when heated to decomposition (Sax and Lewis, 1987); however, incineration with polyethylene results in more than 9 Shipping UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. Purification Methods It crystallises from EtOH (charcoal), then three times from dioxane [Williams et al. J Phys Chem 61 261 1957]. [Beilstein 26 H 137.] Possible carcinogen. [Beilstein 26 H 137, Temple & Montgomery 1,2,4-Triazoles —The Chemistry of Heterocyclic Compounds Vol 37 (Weissberger & Taylor eds.). Wiley & Sons NY 1981, ISBN 0-471-0656-6.] Incompatibilities Dust may be explosive in air. Keep away from strong oxidizers; strong acids; light and heat (decomposes). Corrosive to iron, aluminum, and copper. Sublimes undecomposed at reduced pressure. Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Amitrol is resistant to hydrolysis and the action of oxidizing agents. Burning the compound with polyethylene is reported to result in .99% decomposition.   Triazol-3-amine Preparation Products And Raw materials Raw materials Guanidine nitrate-->Cyanamide-->Aminoguanidine bicarbonate-->AMINOGUANIDINE HEMISULFATE Preparation Products 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE-->Salic

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Triazol-3-amine Basic information Product Name: Triazol-3-amine Synonyms: Amino-s-triazole;AMINOTRIAZOLE;AMIZOLE;AMIZOL(R);AMITROL;AMITROLE;AMITROLE(R);amino-1,2,4-triazole CAS: 61-82-5 MF: C2H4N4 MW: 84.08 EINECS: 200-521-5 Product Categories: ATA;3-Amino-1,2,4-Triazole;AM to AQ;A;Alphabetic;Organic chemical, pesticide;Heterocycles;Organics;Estradiol, etc. (Environmental Endocrine Disruptors);Analytical Chemistry;Environmental Endocrine Disruptors;Agro-Products Mol File: 61-82-5.mol   Triazol-3-amine Chemical Properties Melting point  150-153 °C(lit.) Boiling point  144.35°C (rough estimate) density  1.138 vapor pressure  <0.1 hPa (20 °C) refractive index  1.6260 (estimate) storage temp.  Store below +30°C. solubility  280g/l form  Powder or Flakes pka 11.14±0.20(Predicted) color  White to off-white or yellow PH 6.4-7.4 (100g/l, H2O, 20℃) Water Solubility  280 g/L (20 ºC) Merck  14,489 BRN  107687 Exposure limits NIOSH REL: TWA 0.2 mg/m3; ACGIH TLV: TWA 0.2 mg/m3. Stability: Stable. Incompatible with iron, copper, aluminium, acids, alkalies, strong oxidizing agents, acid chlorides, acid anhydrides. Forms chelates with some metals. Moisture sensitive. CAS DataBase Reference 61-82-5(CAS DataBase Reference) NIST Chemistry Reference 3-Amino-s-triazole(61-82-5) IARC 3 (Vol. 79, Sup 7) 2001 EPA Substance Registry System Amitrole (61-82-5)   Safety Information Hazard Codes  Xn,N,T Risk Statements  48/22-51/53-63-40-61 Safety Statements  13-36/37-61-45-53 RIDADR  UN 3077 9/PG 3 WGK Germany  2 RTECS  XZ3850000 Autoignition Temperature >225 °C TSCA  Yes HazardClass  9 PackingGroup  III HS Code  29339990 Hazardous Substances Data 61-82-5(Hazardous Substances Data) Toxicity LD50 in mice, rats (g/kg): 14.7, 25.0 orally (Krller) MSDS Information Provider Language Amino-s-triazole English SigmaAldrich English ACROS English ALFA English   Triazol-3-amine Usage And Synthesis Chemical Properties white powder or crystals Chemical Properties Amitrole is a colorless to off-white crystalline solid or white powder. Odorless when pure. Uses Nonselective, foliage-applied, systemic, triazole herbicide used in uncropped land and orchards to control certain grasses and to kill annual and perennial grasses and weeds. It is also effective on poison ivy, poison oak and aquatic weeds Uses catalase inhibitor Uses Herbicide; plant regulator. Definition A powerful plant growth suppressant and cotton defoliant that is readily absorbed by leaves and roots. It inhibits many aspects of growth and differentiation including cell division in the primary root meristems in some plants. Production Methods Amitrole is synthesized by condensing formic acid with aminoguanidine and can be purified by recrystallization from methanol. General Description Odorless white crystals or white powder. Bitter taste. Melting point 147-159°C. Sublimes undecomposed at reduced pressure. Used as a post-emergence herbicide. Air & Water Reactions Water soluble. Aqueous solutions are neutral. Dust may form an explosive mixture in air. Reactivity Profile Triazol-3-amine is a triazole derivative. The triazoles are a group that contain several derivatives that are highly explosive materials. They are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. Triazol-3-amine forms chelates with some metals. Triazol-3-amine is corrosive to iron, copper and aluminum. Forms salts with most acids and alkalis. Triazol-3-amine is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides . Hazard Toxic; carcinogen. Health Hazard Amitrole has low acute toxicity; in experimental animal studies subchronic exposures were associated with changes in the thyroid and chronic exposures were carcinogenic. Intentional ingestion of a mixture that contained 20 mg/kg amitrole did not cause any signs of intoxication.1 In one reported case study, inhalation of a large amount of amitrolecontaining herbicide was associated with acute toxic reaction of the lungs.2 Lung injury was thought to be secondary to direct toxic damage to the alveolar lining cells. The remarkable lack of any other reports describing pulmonary toxicity of this herbicide was noted, in addition to the presence of other chemicals in the herbicide solution. Fire Hazard Literature sources indicate that Triazol-3-amine is non-combustible. Agricultural Uses Herbicide, Plant growth regulator: A non-food use herbicide for control of grasses, woody plants and broad-leaf weeds on hard surface and in areas where crops are not normally grown. Trade name AMITRIL®; ATLAZIN®; ATLAZINE® FLOWABLE; AT®; 3-AT®; AT-90®; ATRAFLOW PLUS®; AZAPLANT®; AZAPLANT KOMBI®; AZOLAN®; AZOLE®; BOROFLOW® A/ATA; CAMPAPRIM® A 1544; CDA SIMFLOW PLUS®; CHIPMAN® PATH; CYTROLE®; DIUROL® AMITROLE; DOMATOL®; ELMASIL®; EMISOL®; FARMCO®; HERBAZIN PLUS SC®; HERBICIDE® TOTAL; MASCOT HIGHWAY®; MSS AMINOTRIAZOLE®; MSS SIMAZINE®; ORGA-414®; RADOXONE® TL; RAMIZOL®; RASSAPRON®; SIMAZOL®; SIMFLOW PLUS®; SOLUTION CNCENTREE T271®; SYNCHEMICALS® TOTAL WEED KILLER; SYNTOX®; TORAPRON®; VOROX®; WEEDAR®; WEEDAZIN®; WEEDAZOL TL ®; WEEDOCLOR® Biochem/physiol Actions BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors.Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments. Safety Profile Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. An herbicide and plant growth regulator Potential Exposure A potential danger to those involved in the manufacture, formulation, and application of this postemergence herbicide, which is now limited to noncrop applications as a herbicide and plant growth regulator. Some triazoles have been used as rubber components. Carcinogenicity Amitrole is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. Environmental Fate Soil. When radiolabeled amitrole-5-14C was incubated in a Hagerstown silty clay loam, 50 and 70% of the applied amount evolved as 14CO2 after 3 and 20 days, respectively. In autoclaved soil, however, no 14CO2 was detected. The chemical degradation in soil was probably via hydroxyl radicals (Kaufman et al., 1968). The average persistence in soils is 2–4 weeks (Hartley and Kidd, 1987) Plant.Amitrole is transformed in plants to form the conjugate β-(3-amino-1,2,4-triazol- 1-yl)-α-alanine (Humburg et al., 1989) and/or 3-(3-amino-s-triazole-1-yl)-2-aminopropionic acid (Duke et al., 1991). Amitrole is metabolized in Canada thistl Surface Water. In pond water, adsorption to suspended sediments was an important process. The initial half-life was reported to be no more than 68 days. After 120 days, 20% of the applied amount remained (Grzenda et al., 1966). The biodegradation Photolytic. Direct photolysis of amitrole is not expected to occur since the herbicide shows little or no absorption greater than 295 nm (Gore et al., 1971) Chemical/Physical. Reacts with acids and bases forming soluble salts (Hartley and Kidd, 1987). Emits toxic fumes of nitrogen oxides when heated to decomposition (Sax and Lewis, 1987); however, incineration with polyethylene results in more than 9 Shipping UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. Purification Methods It crystallises from EtOH (charcoal), then three times from dioxane [Williams et al. J Phys Chem 61 261 1957]. [Beilstein 26 H 137.] Possible carcinogen. [Beilstein 26 H 137, Temple & Montgomery 1,2,4-Triazoles —The Chemistry of Heterocyclic Compounds Vol 37 (Weissberger & Taylor eds.). Wiley & Sons NY 1981, ISBN 0-471-0656-6.] Incompatibilities Dust may be explosive in air. Keep away from strong oxidizers; strong acids; light and heat (decomposes). Corrosive to iron, aluminum, and copper. Sublimes undecomposed at reduced pressure. Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Amitrol is resistant to hydrolysis and the action of oxidizing agents. Burning the compound with polyethylene is reported to result in .99% decomposition.   Triazol-3-amine Preparation Products And Raw materials Raw materials Guanidine nitrate-->Cyanamide-->Aminoguanidine bicarbonate-->AMINOGUANIDINE HEMISULFATE Preparation Products 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE-->Salic