China Largest Manufacturer factory sales Thioacetamide CAS 62-55-5 CAS NO.62-55-5

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Thioacetamide Basic information Organic reagents Chemical properties Uses Production method Product Name: Thioacetamide Synonyms: Acetamide, thio-;Acetimidic acid, thio-;Acetothioamide;CH3CSNH2;Rcra waste number U218;rcrawastenumberu218;Thiacetamide;THIOACETAMIDE TS CAS: 62-55-5 MF: C2H5NS MW: 75.13 EINECS: 200-541-4 Product Categories: API;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds;Sulphur Derivatives Mol File: 62-55-5.mol   Thioacetamide Chemical Properties Melting point  108-112 °C (lit.) Boiling point  111.7±23.0 °C(Predicted) density  1.37 refractive index  1.5300 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  passes test2% form  Liquid pka 13.25±0.29(Predicted) color  Off-white to slightly beige PH Range 5.2 PH 5.2 (100g/l, H2O, 20℃) Water Solubility  16.3 g/100 mL (25 ºC) Merck  14,9319 BRN  506006 Stability: Stability Incompatible with water, mineral acids. InChIKey YUKQRDCYNOVPGJ-UHFFFAOYSA-N CAS DataBase Reference 62-55-5(CAS DataBase Reference) NIST Chemistry Reference Ethanethioamide(62-55-5) IARC 2B (Vol. 7, Sup 7) 1987 EPA Substance Registry System Thioacetamide (62-55-5)   Safety Information Hazard Codes  T Risk Statements  45-22-36/38-52/53 Safety Statements  53-45-61-99 RIDADR  2811 WGK Germany  3 RTECS  AC8925000 F  10 TSCA  Yes HS Code  29309070 Hazardous Substances Data 62-55-5(Hazardous Substances Data) Toxicity MLD orally in rats: 200 mg/kg (Ambrose) MSDS Information Provider Language Ethanethioamide English SigmaAldrich English ACROS English ALFA English   Thioacetamide Usage And Synthesis Organic reagents Thioacetamide is organic reagent, it is colorless or white crystalline flake. It is dissolved in water, ethanol, very slightly soluble in benzene, ether, the aqueous solution at room temperature or 50~60℃ is fairly stable, when placed 2 to 3 weeks, it is not change, but when hydrogen ions is in the presence, it quickly decomposes into hydrogen sulfide , but hydrolysis increases with alkalinity or acidity of the solution and the temperature rises quickly. Hydrolysis equations solution of thioacetamide in acidic and basic is: Acidic solution: CH3CSNH2 + 2H2O----(NH4 +) + CH3COO-+ H2S Alkaline solution: CH3CSNH2 + 2OH-----NH3 + CH3COO-+ HS- Since H2S or HS-can generate for hydrolysis in acidic or alkaline solution, so in analytical chemistry, it is often used in place of toxic and odor H2S, as the metal cation group reagents or precipitation reagents. The property of resulting precipitate is good, easy to separate. In addition, it can also be used for bismuth measurement reagent. Preparation method: It can be prepared by heating the acetamide with aluminum sulfide, hydrogen sulfide reacting with acetonitrile, or acetamide reacting with K3PS4. Chemical properties It is colorless or white crystals. Mp is 113-114℃, the solubility in water is 16.3g/100ml at 25℃, ethanol 26.4g/100ml. It is slightly soluble in benzene, ether. Their solution is quite stable at room temperature or 50-60℃, but when hydrogen ions exists, it can generate thiosulfate hydrogen and decompose quickly. New product sometimes has mercaptan odor, slight moisture absorption. The above information is edited by the chemicalbook of Wang Xiaodong. Uses 1. It can be used for the production of catalysts, stabilizers, polymerization inhibitors, electroplating additives, photographic chemicals, pesticides, dyeing auxiliary and processing agents. It can be also used as polymer curing agents, crosslinking agents, rubber additives and pharmaceutical raw materials. 2. It can be also used as vulcanizing agent and crosslinking agent of polymer, rubber additives, pharmaceutical raw materials, etc. 3. It can be also used as analytical reagents. Production method Thioacetamide can be obtained by the reaction of acetonitrile with hydrogen sulfide, or acetamide with phosphorus pentasulfide. Description Thioacetamide (TAA) is not known to occur in nature. It is prepared by heating ammonium acetate and aluminum sulfide. Chemical Properties White solid Chemical Properties Thioacetamide is combustible, crystalline compound. Slight mercaptan odor. Uses It is used as an intermediate in organicsynthesis. Uses Sulfide generation Uses Substitute for H2S in laboratory qualitative analyses. Uses Thioacetamide is a carcinogen, a hepatotoxicant. Thioacetamide induces acute chronic liver injury through the activation of protein synthesis of RNA, DNA, and gamma-glutamyl transpeptitase. Thioacetamide has been used in the synthesis of [email protected] nano-array core-shell structure. Definition ChEBI: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur. General Description White crystals with a mercaptan odor. Air & Water Reactions Slightly water soluble. Reactivity Profile Thioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases . Hazard Toxic by ingestion and inhalation, a possible carcinogen. Health Hazard The toxicity of this compound is moderatein rats; an oral lethal dose is 200 mg/kg.Oral administration of thioacetamide causedliver cancer in rats and mice. It is, however, a weak liver carcinogen. Malvaldi and associates (1988) investigated the mechanism of its carcinogenic activity on rat liver.Whereas the initiating ability of this compound is quite low, its promoting effect isstrong. Thus thioacetamide is a very effectivepromoter of the liver carcinogenesis. A similar promoting activity of liver carcinogenesishas been observed with other thioamide substances, such as thiobenzamide (Malvaldi et al. 1986). Low et al. (2004) have proposed a modelto explain thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. The pathways of thioacetamide-induced liver fibrosiswere found to be initiated by thioacetamideS-oxide derived from the biotransformationof thioacetamide by the microsomal flavinadenine nucleotide containing monooxygenase and cytochrome P450 systems andinvolve oxidative stress and depletion ofsuccinyl-CoA, thus affecting heme and ironmetabolism. Karabay et al. (2005) observedsuch hepatic damage in rats with elevationof total nitrite level in livers and decrease inarginase activity. The authors have reportedthat nitrosative stress was essentially the critical factor in thioacetamide-induced hepaticfailure in rats. Pretreatment of rats with jigrine exhibited hepatoprotective action againstthioacetamide-induced toxicity (Ahmed et al.1999). Thioacetamide decreased the concentration of glutathione in the liver of rats.Jigrine pretreatment, however, restored theglutathione levels to the near normal values.The authors claimed that the effects of jigrinewere comparable to that of silymarin. Thehepatotoxicity in rats was found to potentiatefollowing pretreatment with phenobarbital. Al-Bader et al. (2000) investigated thetoxicity of thioacetamide in the spleen inexperimental animals. The authors foundan intimate association between the levelsof trace metals and spleen pathology, asobserved in studies of other organs. Fire Hazard Flash point data on Thioacetamide are not available; Thioacetamide is probably combustible. Safety Profile Confirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. Exposure has caused liver damage. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFIDES and MERCAPTANS. Potential Exposure Thioacetamide is used as a replacement for hydrogen sulfide in qualitative analyses. Thioacetamide has been used as an organic solvent in the leather, textile, and paper industries; as an accelerator in the vulcanization of buna rubber; and as a stabilizer of motor fuel. Carcinogenicity Thioacetamide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals. Environmental Fate TAA’s production and use as a substitute for hydrogen sulfide in the laboratory may result in its release to the environment through various waste streams. If released to air, TAA’s estimated vapor pressure indicates that it will exist solely as a vapor in the ambient atmosphere. Vapor-phase TAA will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 h. TAA was not biodegraded by activated sludge after 5 days, and therefore may be resistant to biodegradation in the environment. Hydrolysis is not expected since amides hydrolyze very slowly under environmental conditions. An estimated bioconcentration factor for TAA suggests that the potential for bioconcentration in aquatic organisms is low. TAA is expected to be highly mobile in soil, and to volatilize into the atmosphere from moist soil surfaces. In an aquatic environment, most of the substance will leave via volatilization and is not expected to adsorb to solids. Shipping UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Purification Methods Crystallise the amide from absolute diethyl ether or *benzene. Dry it at 70o in a vacuum and store it over P2O5 at 0o under nitrogen. (It develops an obnoxious odour on storage, and absorption at 269nm decreases, hence it should be freshly recrystallised before use). [Beilstein 2 IV 565.] Toxicity evaluation TAA acts as an indirect hepatotoxin and causes parenchymal cell necrosis. It can be metabolized in vivo to acetamide, which itself is carcinogenic. Acetamide is then hydrolyzed to acetate. TAA-induced liver necrosis has been explained by a scheme that includes the metabolic conversion of TAA to its S-oxide, followed by the further metabolism of TAA-S-oxide to a reactive intermediate that can either bind to liver macromolecules or be further degraded to acetamide and polar products. Examples of TAA’s biochemical effects in the liver include glucose-6- phosphate dehydrogenase being induced within days after rats are treated with TAA, and the level of urea product is decreased as are the activities of hepatic carbamyl phosphate synthetase, ornithine transcarbamylase, and arginase. Thus, TAA can produce marked disturbances in the urea cycle in the liver. Further, TAA administered to rats leads to functional disturbances in mitochondria isolated from livers after 24 h, and the maximum respiratory activity of the mitochondria is also depressed, mitochondrial Ca2+ content is significantly increased, and the Ca2+ transport behavior of the hepatic mitochondria is altered. The results are indicative of structural alterations of the inner mitochondrial membranes. The potential role of TAA in the initiation phase of carcinogenesis may be associated with an increase in nucleoside triphosphate activity in cell nuclear envelopes with a corresponding increase in RNA transport activity. Alterations in the transport phenomenon of nuclear RNA sequences are considered an early response to carcinogens. Incompatibilities Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Treatment in an incinerator, boiler or cement kiln.   Thioacetamide Preparation Products And Raw materials Raw materials Phosphorus pentasulfide-->Acetamide Preparation Products 3-(2-METHYL-1,3-THIAZOL-4-YL)BENZOIC ACID-->2-(2,5-DIMETHYL-1,3-THIAZOL-4-YL)ACETIC ACID-->METHYL 2-(2,5-DIMETHYL-1,3-THIAZOL-4-YL)ACETATE-->2,4-Dimethylthiazole-5-carboxylic acid-->Aspoxicillin-->2-Methyl-1,3-thiazole-4-carboxylic acid-->ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE-->4-Butyl-2-methylthiazole-->2-METHYL-4-PHENYL-THIAZOLE-->THIOACETANILIDE-->4-CHLOROMETHYL-2-METHYLTHIAZOLE HYDROCHLORIDE-->6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE-->Trimethyl thiazole-->5-Acetyl-2,4-dimethylthiazole

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Thioacetamide Basic information Organic reagents Chemical properties Uses Production method Product Name: Thioacetamide Synonyms: Acetamide, thio-;Acetimidic acid, thio-;Acetothioamide;CH3CSNH2;Rcra waste number U218;rcrawastenumberu218;Thiacetamide;THIOACETAMIDE TS CAS: 62-55-5 MF: C2H5NS MW: 75.13 EINECS: 200-541-4 Product Categories: API;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds;Sulphur Derivatives Mol File: 62-55-5.mol   Thioacetamide Chemical Properties Melting point  108-112 °C (lit.) Boiling point  111.7±23.0 °C(Predicted) density  1.37 refractive index  1.5300 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  passes test2% form  Liquid pka 13.25±0.29(Predicted) color  Off-white to slightly beige PH Range 5.2 PH 5.2 (100g/l, H2O, 20℃) Water Solubility  16.3 g/100 mL (25 ºC) Merck  14,9319 BRN  506006 Stability: Stability Incompatible with water, mineral acids. InChIKey YUKQRDCYNOVPGJ-UHFFFAOYSA-N CAS DataBase Reference 62-55-5(CAS DataBase Reference) NIST Chemistry Reference Ethanethioamide(62-55-5) IARC 2B (Vol. 7, Sup 7) 1987 EPA Substance Registry System Thioacetamide (62-55-5)   Safety Information Hazard Codes  T Risk Statements  45-22-36/38-52/53 Safety Statements  53-45-61-99 RIDADR  2811 WGK Germany  3 RTECS  AC8925000 F  10 TSCA  Yes HS Code  29309070 Hazardous Substances Data 62-55-5(Hazardous Substances Data) Toxicity MLD orally in rats: 200 mg/kg (Ambrose) MSDS Information Provider Language Ethanethioamide English SigmaAldrich English ACROS English ALFA English   Thioacetamide Usage And Synthesis Organic reagents Thioacetamide is organic reagent, it is colorless or white crystalline flake. It is dissolved in water, ethanol, very slightly soluble in benzene, ether, the aqueous solution at room temperature or 50~60℃ is fairly stable, when placed 2 to 3 weeks, it is not change, but when hydrogen ions is in the presence, it quickly decomposes into hydrogen sulfide , but hydrolysis increases with alkalinity or acidity of the solution and the temperature rises quickly. Hydrolysis equations solution of thioacetamide in acidic and basic is: Acidic solution: CH3CSNH2 + 2H2O----(NH4 +) + CH3COO-+ H2S Alkaline solution: CH3CSNH2 + 2OH-----NH3 + CH3COO-+ HS- Since H2S or HS-can generate for hydrolysis in acidic or alkaline solution, so in analytical chemistry, it is often used in place of toxic and odor H2S, as the metal cation group reagents or precipitation reagents. The property of resulting precipitate is good, easy to separate. In addition, it can also be used for bismuth measurement reagent. Preparation method: It can be prepared by heating the acetamide with aluminum sulfide, hydrogen sulfide reacting with acetonitrile, or acetamide reacting with K3PS4. Chemical properties It is colorless or white crystals. Mp is 113-114℃, the solubility in water is 16.3g/100ml at 25℃, ethanol 26.4g/100ml. It is slightly soluble in benzene, ether. Their solution is quite stable at room temperature or 50-60℃, but when hydrogen ions exists, it can generate thiosulfate hydrogen and decompose quickly. New product sometimes has mercaptan odor, slight moisture absorption. The above information is edited by the chemicalbook of Wang Xiaodong. Uses 1. It can be used for the production of catalysts, stabilizers, polymerization inhibitors, electroplating additives, photographic chemicals, pesticides, dyeing auxiliary and processing agents. It can be also used as polymer curing agents, crosslinking agents, rubber additives and pharmaceutical raw materials. 2. It can be also used as vulcanizing agent and crosslinking agent of polymer, rubber additives, pharmaceutical raw materials, etc. 3. It can be also used as analytical reagents. Production method Thioacetamide can be obtained by the reaction of acetonitrile with hydrogen sulfide, or acetamide with phosphorus pentasulfide. Description Thioacetamide (TAA) is not known to occur in nature. It is prepared by heating ammonium acetate and aluminum sulfide. Chemical Properties White solid Chemical Properties Thioacetamide is combustible, crystalline compound. Slight mercaptan odor. Uses It is used as an intermediate in organicsynthesis. Uses Sulfide generation Uses Substitute for H2S in laboratory qualitative analyses. Uses Thioacetamide is a carcinogen, a hepatotoxicant. Thioacetamide induces acute chronic liver injury through the activation of protein synthesis of RNA, DNA, and gamma-glutamyl transpeptitase. Thioacetamide has been used in the synthesis of [email protected] nano-array core-shell structure. Definition ChEBI: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur. General Description White crystals with a mercaptan odor. Air & Water Reactions Slightly water soluble. Reactivity Profile Thioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases . Hazard Toxic by ingestion and inhalation, a possible carcinogen. Health Hazard The toxicity of this compound is moderatein rats; an oral lethal dose is 200 mg/kg.Oral administration of thioacetamide causedliver cancer in rats and mice. It is, however, a weak liver carcinogen. Malvaldi and associates (1988) investigated the mechanism of its carcinogenic activity on rat liver.Whereas the initiating ability of this compound is quite low, its promoting effect isstrong. Thus thioacetamide is a very effectivepromoter of the liver carcinogenesis. A similar promoting activity of liver carcinogenesishas been observed with other thioamide substances, such as thiobenzamide (Malvaldi et al. 1986). Low et al. (2004) have proposed a modelto explain thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. The pathways of thioacetamide-induced liver fibrosiswere found to be initiated by thioacetamideS-oxide derived from the biotransformationof thioacetamide by the microsomal flavinadenine nucleotide containing monooxygenase and cytochrome P450 systems andinvolve oxidative stress and depletion ofsuccinyl-CoA, thus affecting heme and ironmetabolism. Karabay et al. (2005) observedsuch hepatic damage in rats with elevationof total nitrite level in livers and decrease inarginase activity. The authors have reportedthat nitrosative stress was essentially the critical factor in thioacetamide-induced hepaticfailure in rats. Pretreatment of rats with jigrine exhibited hepatoprotective action againstthioacetamide-induced toxicity (Ahmed et al.1999). Thioacetamide decreased the concentration of glutathione in the liver of rats.Jigrine pretreatment, however, restored theglutathione levels to the near normal values.The authors claimed that the effects of jigrinewere comparable to that of silymarin. Thehepatotoxicity in rats was found to potentiatefollowing pretreatment with phenobarbital. Al-Bader et al. (2000) investigated thetoxicity of thioacetamide in the spleen inexperimental animals. The authors foundan intimate association between the levelsof trace metals and spleen pathology, asobserved in studies of other organs. Fire Hazard Flash point data on Thioacetamide are not available; Thioacetamide is probably combustible. Safety Profile Confirmed carcinogen with experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. Exposure has caused liver damage. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFIDES and MERCAPTANS. Potential Exposure Thioacetamide is used as a replacement for hydrogen sulfide in qualitative analyses. Thioacetamide has been used as an organic solvent in the leather, textile, and paper industries; as an accelerator in the vulcanization of buna rubber; and as a stabilizer of motor fuel. Carcinogenicity Thioacetamide is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals. Environmental Fate TAA’s production and use as a substitute for hydrogen sulfide in the laboratory may result in its release to the environment through various waste streams. If released to air, TAA’s estimated vapor pressure indicates that it will exist solely as a vapor in the ambient atmosphere. Vapor-phase TAA will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 h. TAA was not biodegraded by activated sludge after 5 days, and therefore may be resistant to biodegradation in the environment. Hydrolysis is not expected since amides hydrolyze very slowly under environmental conditions. An estimated bioconcentration factor for TAA suggests that the potential for bioconcentration in aquatic organisms is low. TAA is expected to be highly mobile in soil, and to volatilize into the atmosphere from moist soil surfaces. In an aquatic environment, most of the substance will leave via volatilization and is not expected to adsorb to solids. Shipping UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Purification Methods Crystallise the amide from absolute diethyl ether or *benzene. Dry it at 70o in a vacuum and store it over P2O5 at 0o under nitrogen. (It develops an obnoxious odour on storage, and absorption at 269nm decreases, hence it should be freshly recrystallised before use). [Beilstein 2 IV 565.] Toxicity evaluation TAA acts as an indirect hepatotoxin and causes parenchymal cell necrosis. It can be metabolized in vivo to acetamide, which itself is carcinogenic. Acetamide is then hydrolyzed to acetate. TAA-induced liver necrosis has been explained by a scheme that includes the metabolic conversion of TAA to its S-oxide, followed by the further metabolism of TAA-S-oxide to a reactive intermediate that can either bind to liver macromolecules or be further degraded to acetamide and polar products. Examples of TAA’s biochemical effects in the liver include glucose-6- phosphate dehydrogenase being induced within days after rats are treated with TAA, and the level of urea product is decreased as are the activities of hepatic carbamyl phosphate synthetase, ornithine transcarbamylase, and arginase. Thus, TAA can produce marked disturbances in the urea cycle in the liver. Further, TAA administered to rats leads to functional disturbances in mitochondria isolated from livers after 24 h, and the maximum respiratory activity of the mitochondria is also depressed, mitochondrial Ca2+ content is significantly increased, and the Ca2+ transport behavior of the hepatic mitochondria is altered. The results are indicative of structural alterations of the inner mitochondrial membranes. The potential role of TAA in the initiation phase of carcinogenesis may be associated with an increase in nucleoside triphosphate activity in cell nuclear envelopes with a corresponding increase in RNA transport activity. Alterations in the transport phenomenon of nuclear RNA sequences are considered an early response to carcinogens. Incompatibilities Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Waste Disposal Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Treatment in an incinerator, boiler or cement kiln.   Thioacetamide Preparation Products And Raw materials Raw materials Phosphorus pentasulfide-->Acetamide Preparation Products 3-(2-METHYL-1,3-THIAZOL-4-YL)BENZOIC ACID-->2-(2,5-DIMETHYL-1,3-THIAZOL-4-YL)ACETIC ACID-->METHYL 2-(2,5-DIMETHYL-1,3-THIAZOL-4-YL)ACETATE-->2,4-Dimethylthiazole-5-carboxylic acid-->Aspoxicillin-->2-Methyl-1,3-thiazole-4-carboxylic acid-->ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE-->4-Butyl-2-methylthiazole-->2-METHYL-4-PHENYL-THIAZOLE-->THIOACETANILIDE-->4-CHLOROMETHYL-2-METHYLTHIAZOLE HYDROCHLORIDE-->6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE-->Trimethyl thiazole-->5-Acetyl-2,4-dimethylthiazole