China Largest Manufacturer factory Supply Gastrodin CAS 62499-27-8 CAS NO.62499-27-8

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Gastrodin Basic information Product Name: Gastrodin Synonyms: 4-hydroxybenzyl alcohol 4-o-bata-d-glucoside;4-O-BETA-D-GLUCOPYRANOSYLOXYBENZYL ALCOHOL;(2R,3S,4S,5R,6S)-2-HYDROXYMETHYL-6-(4-HYDROXYMETHYL-PHENOXY)-TETRAHYDRO-PYRAN-3,4,5-TRIOL;Gastro enterical;Gastrodin ,98%;4-(Hydroxymethyl)phenyl β-D-glucopyranoside;4-(β-D-Glucopyranosyloxy)benzyl alcohol;p-(Hydroxymethyl)phenyl β-D-glucopyranoside CAS: 62499-27-8 MF: C13H18O7 MW: 286.28 EINECS: 683-202-7 Product Categories: chemical reagent;pharmaceutical intermediate;Benzhydrols, Benzyl & Special Alcohols;Natural Plant Extract;APIS;Herb extract;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors Mol File: 62499-27-8.mol   Gastrodin Chemical Properties Melting point  169-170° alpha  D20 -17.5° (c = 1 in pyridine) Boiling point  563.2±50.0 °C(Predicted) density  1.504±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly, Sonicated) form  Solid pka 9.10(at 25℃) color  White to Off-White λmax 272nm(MeOH)(lit.) Merck  14,4375 CAS DataBase Reference 62499-27-8(CAS DataBase Reference)   Safety Information RTECS  LZ5776885 HS Code  29329990 MSDS Information   Gastrodin Usage And Synthesis Description Gastrodin is extracted from the dry root of the orchid plant, Gastrodia elata. The source of raw materials is Yunnan Province. Traditional Chinese medicine Gastrodia elata (Gastrodia elata Bl.) is also known as Chi Jian, Ding Feng Cao, Shui Yang Yu, and so on, belonging to special symbiosis perennial herb of Orchidaceae and Armillaria mellea. The medicinal part is its tubers. It has sweet flavor and liver channel tropism and is neutral in nature. Traditional Chinese medicine believes that its main functions are to expel wind and relieve convulsion, calm the liver and suppress liver-yang, and expel wind evil and channel. There are 23 chemical ingredients extracted from Gastrodia elata, including gastrodin, gastrodia glycosides, vanilla alcohol, vanilla aldehyde, beta steroid valley alcohol, p-hydroxybenzoic acid, carrot glycosides, and so on, among which the highest content of single active ingredient is Gastrodia glycosides, namely, gastrodin Chemical Properties White solid Physical properties Appearance: white prismatic crystal, odorless, and bitter; little hygroscopicity. Solubility: soluble in water, methanol, ethanol, acetone, and acetonyl acetate, insoluble in chloroform, and poorly soluble in ethyl ether. Melting point: 153 to 156 °C. Specific optical rotation: 68 to 72° . History It has been more than 30 years since the chemical composition of Gastrodia elata was analyzed. It includes phenols, organic acids, sterols, and so on. At present, the studies of the composition of Gastrodia elata focus on the fingerprint, but the studies of gastrodin were centered on the activity. The studies showed that gastrodin has many pharmacological effects with safety and few side effects; moreover, it is not easy to accumulate in the body. Based on traditional medicinal experience of Gastrodia elata, gastrodin has been developed as a medicine for the treatment of insomnia, headaches, and other symptoms related to the functions and indications of Gastrodia elata. At present, many pharmaceutical factories in China have produced active pharmaceutical ingredients (API) and general preparation of gastrodin, such as Gastrodia tablet, Gastrodia capsule, and Gastrodia injection. To reduce the frequency of administration, the fluctuations of blood drug concentration, as well as side effects, some new dosage forms have been developed in recent years, such as Gastrodia dispersible tablets, Gastrodia sustained-release tablet, sustained-release pellets and osmotic pump tablets, etc. . Although gastrodin has been applied clinically, a lot of studies still need to be done to confirm the pharmacological effects of gastrodin. Recent studies found that other compositions of Gastrodia elata also showed rather excellent biological activity, suggesting that the study of Gastrodia elata and gastrodin needs further investigation. Uses Gastrodin up regulates heme oxygenase-1 expression through activation of p38 MAPK/Nrf2 signaling pathway thus protecting the SH-SY5Y cells from MPP+-induced oxidative cell death. Indications Gastrodin is included in the International Pharmacopoeia (5th ed.). The dosage forms include injections, tablets, and capsules. They are widely used for the treatment of vertigo (Meniere’s disease, medicinal dizziness, traumatic vertigo, sudden deafness, vestibular neuronitis, vertebrobasilar insufficiency, etc.), headache (vascular headache, migraine, etc.), neuralgia (trigeminal neuralgia, sciatica, etc.), neurasthenia syndrome, and brain traumatic syndrome . Pharmacology Gastrodin has the pharmacological effects of hypnosis, sedation, and anticonvulsive. The pentobarbital sodium-induced sleep time test and sodium barbital-induced sleep onset latency test demonstrated that gastrodin can prolong the sleeping time and shorten the sleep onset latency in mouse, suggesting that gastrodin has the sedative and hypnotic effects . Gastrodin also has antiepileptic effect. It suggested that gastrodin may inhibit the hippocampal excitatory neurotransmitter receptors of amino acid glutamate, activate hippocampal inhibitory neurotransmitter receptor of GABA, reduce the excitability of the cerebral cortex, and thus attenuate the development of epilepsy to play a role of antiepileptic effect . Additionally, research has shown that gastrodin has certain pharmacological effect on scavenging free radicals and inhibiting the central nerve cell apoptosis, etc., which may be related to antiaging and neural protection . According to the available references, the researches of pharmacology and clinical efficacy of gastrodin are very preliminary; more research evidences still need to confirm whether gastrodin is the active constituent of rhizoma gastrodiae. Clinical Use Gastrodin has sedative and hypnotic, analgesia, and immune enhancement function and is used for the treatment of tension headache to relieve pain and intense sentiment and thus further relieve the related symptoms . Clinical usage of gastrodin acupoint injection to treat insomnia also achieves certain effect . Moreover, gastrodin agents have been used for the treatment of cardiovascular diseases and microcirculation system, such as hypertension and coronary heart disease without obvious side effects . It is also reported that gastrodin can treat epilepsy, vascular dementia, deafness, tinnitus, herpes zoster, osteoarthritis, cognitive impairment, and so on but still needs further investigation.   Gastrodin Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Gastrodin Basic information Product Name: Gastrodin Synonyms: 4-hydroxybenzyl alcohol 4-o-bata-d-glucoside;4-O-BETA-D-GLUCOPYRANOSYLOXYBENZYL ALCOHOL;(2R,3S,4S,5R,6S)-2-HYDROXYMETHYL-6-(4-HYDROXYMETHYL-PHENOXY)-TETRAHYDRO-PYRAN-3,4,5-TRIOL;Gastro enterical;Gastrodin ,98%;4-(Hydroxymethyl)phenyl β-D-glucopyranoside;4-(β-D-Glucopyranosyloxy)benzyl alcohol;p-(Hydroxymethyl)phenyl β-D-glucopyranoside CAS: 62499-27-8 MF: C13H18O7 MW: 286.28 EINECS: 683-202-7 Product Categories: chemical reagent;pharmaceutical intermediate;Benzhydrols, Benzyl & Special Alcohols;Natural Plant Extract;APIS;Herb extract;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors Mol File: 62499-27-8.mol   Gastrodin Chemical Properties Melting point  169-170° alpha  D20 -17.5° (c = 1 in pyridine) Boiling point  563.2±50.0 °C(Predicted) density  1.504±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly, Sonicated) form  Solid pka 9.10(at 25℃) color  White to Off-White λmax 272nm(MeOH)(lit.) Merck  14,4375 CAS DataBase Reference 62499-27-8(CAS DataBase Reference)   Safety Information RTECS  LZ5776885 HS Code  29329990 MSDS Information   Gastrodin Usage And Synthesis Description Gastrodin is extracted from the dry root of the orchid plant, Gastrodia elata. The source of raw materials is Yunnan Province. Traditional Chinese medicine Gastrodia elata (Gastrodia elata Bl.) is also known as Chi Jian, Ding Feng Cao, Shui Yang Yu, and so on, belonging to special symbiosis perennial herb of Orchidaceae and Armillaria mellea. The medicinal part is its tubers. It has sweet flavor and liver channel tropism and is neutral in nature. Traditional Chinese medicine believes that its main functions are to expel wind and relieve convulsion, calm the liver and suppress liver-yang, and expel wind evil and channel. There are 23 chemical ingredients extracted from Gastrodia elata, including gastrodin, gastrodia glycosides, vanilla alcohol, vanilla aldehyde, beta steroid valley alcohol, p-hydroxybenzoic acid, carrot glycosides, and so on, among which the highest content of single active ingredient is Gastrodia glycosides, namely, gastrodin Chemical Properties White solid Physical properties Appearance: white prismatic crystal, odorless, and bitter; little hygroscopicity. Solubility: soluble in water, methanol, ethanol, acetone, and acetonyl acetate, insoluble in chloroform, and poorly soluble in ethyl ether. Melting point: 153 to 156 °C. Specific optical rotation: 68 to 72° . History It has been more than 30 years since the chemical composition of Gastrodia elata was analyzed. It includes phenols, organic acids, sterols, and so on. At present, the studies of the composition of Gastrodia elata focus on the fingerprint, but the studies of gastrodin were centered on the activity. The studies showed that gastrodin has many pharmacological effects with safety and few side effects; moreover, it is not easy to accumulate in the body. Based on traditional medicinal experience of Gastrodia elata, gastrodin has been developed as a medicine for the treatment of insomnia, headaches, and other symptoms related to the functions and indications of Gastrodia elata. At present, many pharmaceutical factories in China have produced active pharmaceutical ingredients (API) and general preparation of gastrodin, such as Gastrodia tablet, Gastrodia capsule, and Gastrodia injection. To reduce the frequency of administration, the fluctuations of blood drug concentration, as well as side effects, some new dosage forms have been developed in recent years, such as Gastrodia dispersible tablets, Gastrodia sustained-release tablet, sustained-release pellets and osmotic pump tablets, etc. . Although gastrodin has been applied clinically, a lot of studies still need to be done to confirm the pharmacological effects of gastrodin. Recent studies found that other compositions of Gastrodia elata also showed rather excellent biological activity, suggesting that the study of Gastrodia elata and gastrodin needs further investigation. Uses Gastrodin up regulates heme oxygenase-1 expression through activation of p38 MAPK/Nrf2 signaling pathway thus protecting the SH-SY5Y cells from MPP+-induced oxidative cell death. Indications Gastrodin is included in the International Pharmacopoeia (5th ed.). The dosage forms include injections, tablets, and capsules. They are widely used for the treatment of vertigo (Meniere’s disease, medicinal dizziness, traumatic vertigo, sudden deafness, vestibular neuronitis, vertebrobasilar insufficiency, etc.), headache (vascular headache, migraine, etc.), neuralgia (trigeminal neuralgia, sciatica, etc.), neurasthenia syndrome, and brain traumatic syndrome . Pharmacology Gastrodin has the pharmacological effects of hypnosis, sedation, and anticonvulsive. The pentobarbital sodium-induced sleep time test and sodium barbital-induced sleep onset latency test demonstrated that gastrodin can prolong the sleeping time and shorten the sleep onset latency in mouse, suggesting that gastrodin has the sedative and hypnotic effects . Gastrodin also has antiepileptic effect. It suggested that gastrodin may inhibit the hippocampal excitatory neurotransmitter receptors of amino acid glutamate, activate hippocampal inhibitory neurotransmitter receptor of GABA, reduce the excitability of the cerebral cortex, and thus attenuate the development of epilepsy to play a role of antiepileptic effect . Additionally, research has shown that gastrodin has certain pharmacological effect on scavenging free radicals and inhibiting the central nerve cell apoptosis, etc., which may be related to antiaging and neural protection . According to the available references, the researches of pharmacology and clinical efficacy of gastrodin are very preliminary; more research evidences still need to confirm whether gastrodin is the active constituent of rhizoma gastrodiae. Clinical Use Gastrodin has sedative and hypnotic, analgesia, and immune enhancement function and is used for the treatment of tension headache to relieve pain and intense sentiment and thus further relieve the related symptoms . Clinical usage of gastrodin acupoint injection to treat insomnia also achieves certain effect . Moreover, gastrodin agents have been used for the treatment of cardiovascular diseases and microcirculation system, such as hypertension and coronary heart disease without obvious side effects . It is also reported that gastrodin can treat epilepsy, vascular dementia, deafness, tinnitus, herpes zoster, osteoarthritis, cognitive impairment, and so on but still needs further investigation.   Gastrodin Preparation Products And Raw materials